Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
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Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
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Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Recchiuti A | Resolvin D1 and its GPCRs in resolution circuits of inflammation. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500003 |
Gladyshev MI et al. | Production of EPA and DHA in aquatic ecosystems and their transfer to the land. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500063 |
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Monia ZA et al. | Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653768 |
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Cavazos DA et al. | Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. | 2011 | Prostate | pmid:21360560 |
Nadalin S et al. | Niacin skin flush test: a research tool for studying schizophrenia. | 2010 | Psychiatr Danub | pmid:20305586 |
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Rees AM et al. | Omega-3 deficiency associated with perinatal depression: case control study. | 2009 | Psychiatry Res | pmid:19268372 |
Parker GB et al. | Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. | 2006 | Psychiatry Res | pmid:16499974 |
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Kale A et al. | Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. | 2010 | Psychiatry Res | pmid:19969375 |
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Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
McNamara RK et al. | Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. | 2009 | Psychoneuroendocrinology | pmid:19046819 |
Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Conklin SM et al. | High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | 2007 | Psychosom Med | pmid:17991818 |
Amin AA et al. | Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels. | 2008 | Psychosom Med | pmid:18842751 |
Lucas M et al. | Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada). | 2009 | Public Health Nutr | pmid:19243672 |
Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
Lucas M et al. | n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. | 2010 | Public Health Nutr | pmid:19433004 |
Mendez MA et al. | Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years. | 2009 | Public Health Nutr | pmid:19026093 |
Lucas M et al. | Validation of an FFQ for evaluation of EPA and DHA intake. | 2009 | Public Health Nutr | pmid:19102810 |
Wang B et al. | Resolvin D1 protects mice from LPS-induced acute lung injury. | 2011 | Pulm Pharmacol Ther | pmid:21501693 |
Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
Pacetti D et al. | High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15386630 |
Chen S | Highly pure phospholipids based brain docosahexaenoic acid transporters. | 2010 | Recent Pat CNS Drug Discov | pmid:19832689 |
Chen S and Chen R | Docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements. | 2010 | Recent Pat Food Nutr Agric | pmid:20863272 |
Balestrieri GP et al. | Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. | 1996 | Recenti Prog Med | pmid:8650428 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2002 | Regul. Toxicol. Pharmacol. | pmid:12052009 |
Abril R et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. | 2003 | Regul. Toxicol. Pharmacol. | pmid:12662911 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350202 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350203 |
Blum R et al. | Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17933446 |
Blum R et al. | One-generation reproductive toxicity study of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17976878 |
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Kaeoket K et al. | Effect of docosahexaenoic acid on quality of cryopreserved boar semen in different breeds. | 2010 | Reprod. Domest. Anim. | pmid:19090818 |
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Nordgren TM et al. | Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. | 2013 | Respir. Res. | pmid:23663457 |
Liao Z et al. | Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. | 2012 | Respir. Res. | pmid:23199346 |
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Spaide RF et al. | Characterization of peroxidized lipids in Bruch's membrane. | 1999 | Retina (Philadelphia, Pa.) | pmid:10213241 |
Gustavsson C et al. | Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. | 2008 | Retina (Philadelphia, Pa.) | pmid:18398369 |
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