Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reardon HT et al. | Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22398025 |
Lee HJ et al. | Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. | 2013 | Int. J. Biochem. Cell Biol. | pmid:24120851 |
Offman E et al. | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. | 2013 | Vasc Health Risk Manag | pmid:24124374 |
Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
Galvao TF et al. | Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23103493 |
Hegarty B and Parker G | Fish oil as a management component for mood disorders - an evolving signal. | 2013 | Curr Opin Psychiatry | pmid:23108232 |
Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
Yang YC et al. | Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. | 2013 | J. Nutr. Biochem. | pmid:22901690 |
Tsuboi H et al. | Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. | 2013 | Clin Nutr | pmid:22901744 |
Lindberg M et al. | Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. | 2013 | Br. J. Nutr. | pmid:22846205 |
MacLean E et al. | n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. | 2013 | Br. J. Nutr. | pmid:22849952 |
Hu Y et al. | 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. | 2013 | Carcinogenesis | pmid:23066085 |
Tang Y et al. | Proresolution therapy for the treatment of delayed healing of diabetic wounds. | 2013 | Diabetes | pmid:23043160 |
Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Drover JR et al. | Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. | 2013 | Early Hum. Dev. | pmid:23411369 |
Sundrani D et al. | Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. | 2013 | Reproduction | pmid:23412981 |
Chien KL et al. | A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. | 2013 | BMC Med Res Methodol | pmid:23414574 |
Maskrey BH et al. | Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. | 2013 | Mol Nutr Food Res | pmid:23417926 |
Lapillonne A et al. | Lipid needs of preterm infants: updated recommendations. | 2013 | J. Pediatr. | pmid:23445847 |
Lagarde M et al. | Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22520055 |
Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. | 2013 | Bioprocess Biosyst Eng | pmid:23053417 |
Hjorth E et al. | Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. | 2013 | J. Alzheimers Dis. | pmid:23481688 |
Lee MS et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. | 2013 | Nutrients | pmid:23698161 |
Snodgrass RG et al. | Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. | 2013 | J. Immunol. | pmid:24043885 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Kang JX and Gleason ED | Omega-3 Fatty acids and hippocampal neurogenesis in depression. | 2013 | CNS Neurol Disord Drug Targets | pmid:23574158 |
Yamaguchi M et al. | Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. | 2013 | J Occup Health | pmid:23574777 |
Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
De Genaro P et al. | Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23580485 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Berberovic E et al. | Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23480524 |
Lee HN et al. | Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. | 2013 | J. Cell. Sci. | pmid:23788426 |
Araújo JR et al. | Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. | 2013 | J. Nutr. Biochem. | pmid:23790250 |
Russell KL et al. | Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23796971 |
Xue Z et al. | Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. | 2013 | Nat. Biotechnol. | pmid:23873085 |
Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
Montes R et al. | Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. | 2013 | Eur J Clin Nutr | pmid:23549201 |
Emmett R et al. | Expanding awareness of docosahexaenoic acid during pregnancy. | 2013 | Nutrients | pmid:23549329 |
Haller MJ et al. | Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. | 2013 | Biol. Blood Marrow Transplant. | pmid:23611977 |
Chen J et al. | Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. | 2013 | Food Chem. Toxicol. | pmid:23590892 |
Damsgaard CT et al. | n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. | 2013 | Br. J. Nutr. | pmid:23591057 |
Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
Dalli J et al. | Novel n-3 immunoresolvents: structures and actions. | 2013 | Sci Rep | pmid:23736886 |
Devaraj S et al. | Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. | 2013 | Atherosclerosis | pmid:23528830 |
Finlin BS et al. | Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. | 2013 | J. Nutr. Biochem. | pmid:23528972 |
Rashid MA et al. | N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. | 2013 | J. Neurochem. | pmid:23570577 |
Shiraishi M et al. | Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. | 2013 | Nutr Res | pmid:23746563 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Thomas J et al. | Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. | 2013 | J. Nutr. Biochem. | pmid:23746933 |
Wu JH et al. | Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. | 2013 | J Am Heart Assoc | pmid:24145742 |
Végran F et al. | Socs3 induction by PPARγ restrains cancer-promoting inflammation. | 2013 | Cell Cycle | pmid:23803735 |
Bruno MJ et al. | Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. | 2013 | Faraday Discuss. | pmid:23805753 |
Jung SB et al. | Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23806688 |
Decsi T and Boehm G | trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. | 2013 | Am. J. Clin. Nutr. | pmid:23824720 |
Lundström SL et al. | Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. | 2013 | Mol Nutr Food Res | pmid:23824870 |
Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
Qu L et al. | Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. | 2013 | Bioprocess Biosyst Eng | pmid:23673897 |
Schuchardt JP and Hahn A | Bioavailability of long-chain omega-3 fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23676322 |
Kitson AP et al. | Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23764042 |
Taha AY et al. | A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. | 2013 | Epilepsy Behav | pmid:23376336 |
Collins MA et al. | Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | 2013 | Neurotox Res | pmid:23184649 |
Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
Ostapchenko VG et al. | Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. | 2013 | J. Neurochem. | pmid:23651058 |
Ramkumar HL et al. | Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. | 2013 | J. Nutr. | pmid:23677863 |
Nobre ME et al. | Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. | 2013 | Nutr Res | pmid:23684444 |
Xu ZZ et al. | Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. | 2013 | Ann. Neurol. | pmid:23686636 |
Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
Opperman M and Benade S | Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. | 2013 | Cardiovasc J Afr | pmid:24240381 |
Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
Rosa A et al. | Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. | 2013 | Food Chem. Toxicol. | pmid:23948356 |
Bjorgvinsdottir L et al. | Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? | 2013 | Cardiology | pmid:23948862 |
Lee AL and Park Y | The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. | 2013 | Ann. Nutr. Metab. | pmid:23949659 |
Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
Fogagnolo Mauricio A et al. | Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. | 2013 | Clin Nutr | pmid:23218947 |
Nobili V et al. | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23220074 |
Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
van der Merwe LF et al. | Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. | 2013 | Am. J. Clin. Nutr. | pmid:23221579 |
Betancor MB et al. | Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23202658 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Zeilmaker MJ et al. | Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. | 2013 | Food Chem. Toxicol. | pmid:22079313 |
Wu BT et al. | Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. | 2013 | Br. J. Nutr. | pmid:22691303 |
Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
Borghetti G et al. | Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. | 2013 | Braz. J. Med. Biol. Res. | pmid:24036940 |
Marcon R et al. | Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. | 2013 | J. Immunol. | pmid:24038091 |
Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
Denis I et al. | Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. | 2013 | Ageing Res. Rev. | pmid:23395782 |
Yan Y et al. | Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. | 2013 | Bioresour. Technol. | pmid:23347925 |
Jaudszus A et al. | Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. | 2013 | J. Lipid Res. | pmid:23349208 |
Neuhofer A et al. | Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. | 2013 | Diabetes | pmid:23349501 |
Sofi F et al. | The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. | 2013 | Asia Pac J Clin Nutr | pmid:23353608 |
McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |