DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim HW et al. | Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. | 2011 | Biochim. Biophys. Acta | pmid:21070866 |
| Hashimoto M and Hossain S | Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease. | 2011 | J. Pharmacol. Sci. | pmid:21606627 |
| Madden J et al. | The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. | 2011 | Annu. Rev. Nutr. | pmid:21568708 |
| Musto AE et al. | The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. | 2011 | Epilepsia | pmid:21569016 |
| Corsetto PA et al. | Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. | 2011 | Lipids Health Dis | pmid:21569413 |
| Asensio-Sánchez VM | [Essential polyunsaturated fatty acids]. | 2011 | Arch Soc Esp Oftalmol | pmid:21569923 |
| Eckert GP et al. | Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. | 2011 | Biochim. Biophys. Acta | pmid:21036142 |
| Bonnet N and Ferrari SL | Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. | 2011 | J. Nutr. Biochem. | pmid:21036590 |
| Yates CM et al. | Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells. | 2011 | J. Nutr. | pmid:21613456 |
| Freeman MP et al. | Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. | 2011 | Menopause | pmid:21037490 |
| Mills JD et al. | Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. | 2011 | Neurosurgery | pmid:21135750 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Vinayavekhin N and Saghatelian A | Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. | 2011 | J. Am. Chem. Soc. | pmid:21973308 |
| Hull MA | Omega-3 polyunsaturated fatty acids. | 2011 | Best Pract Res Clin Gastroenterol | pmid:22122770 |
| Wei MY and Jacobson TA | Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. | 2011 | Curr Atheroscler Rep | pmid:21975919 |
| Turgut S et al. | The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. | 2011 | J Basic Clin Physiol Pharmacol | pmid:22865430 |
| Golub N et al. | Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. | 2011 | Med. Hypotheses | pmid:21981905 |
| Sanden M et al. | Atlantic salmon (Salmo salar L.) as a net producer of long-chain marine ω-3 fatty acids. | 2011 | J. Agric. Food Chem. | pmid:22017199 |
| Kumosani TA and Moselhy SS | Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. | 2011 | Hum Exp Toxicol | pmid:20488854 |
| Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
| Ruusunen A et al. | Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. | 2011 | Eur J Nutr | pmid:20574779 |
| Zeng Y et al. | Development of a temperature shift strategy for efficient docosahexaenoic acid production by a marine fungoid protist, Schizochytrium sp. HX-308. | 2011 | Appl. Biochem. Biotechnol. | pmid:21120635 |
| Itakura H et al. | Relationships between plasma fatty acid composition and coronary artery disease. | 2011 | J. Atheroscler. Thromb. | pmid:21099130 |
| Sullivan JC et al. | Modeling the primary oxidation in commercial fish oil preparations. | 2011 | Lipids | pmid:21104333 |
| Shulse CN and Allen EE | Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment. | 2011 | Environ. Microbiol. | pmid:21105981 |
| Koletzko B et al. | Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. | 2011 | Am. J. Clin. Nutr. | pmid:21106917 |
| Lu FS et al. | Oxidative stability of marine phospholipids in the liposomal form and their applications. | 2011 | Lipids | pmid:21088919 |
| Mozaffarian D et al. | Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. | 2011 | Ann. Intern. Med. | pmid:21810709 |
| Kalupahana NS et al. | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. | 2011 | Adv Nutr | pmid:22332072 |
| Wiese DM et al. | The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. | 2011 | Nutr Clin Pract | pmid:21775642 |
| Madec S et al. | CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. | 2011 | Drug Metab. Dispos. | pmid:21778351 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Molinari R et al. | The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. | 2011 | Cancer Immunol. Immunother. | pmid:21779875 |
| Lai LH et al. | [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21781602 |
| Serhan CN and Petasis NA | Resolvins and protectins in inflammation resolution. | 2011 | Chem. Rev. | pmid:21766791 |
| Pan JP et al. | Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. | 2011 | Brain Res. | pmid:21803345 |
| Imhoff-Kunsch B et al. | Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. | 2011 | Pediatrics | pmid:21807696 |
| Hajjaji N et al. | Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. | 2011 | Lipids | pmid:21638063 |
| Kuang YL et al. | Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β. | 2011 | Am. J. Clin. Nutr. | pmid:21653803 |
| Roqueta-Rivera M et al. | Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. | 2011 | Biol. Reprod. | pmid:21653892 |
| Nakamoto K et al. | Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. | 2011 | Eur. J. Pharmacol. | pmid:21658380 |
| Martin CR et al. | Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. | 2011 | J. Pediatr. | pmid:21658712 |
| Vargas ML et al. | Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. | 2011 | Metab. Clin. Exp. | pmid:21640360 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Murakami M | Lipid mediators in life science. | 2011 | Exp. Anim. | pmid:21325748 |
| Kimura F et al. | Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. | 2011 | Lipids | pmid:21901511 |
| Lewis MD et al. | Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. | 2011 | J Clin Psychiatry | pmid:21903029 |
| Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
| Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
| Stapleton RD et al. | A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. | 2011 | Crit. Care Med. | pmid:21423000 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Kulkarni A et al. | Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. | 2011 | PLoS ONE | pmid:21423696 |
| Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid by a newly isolated microalga, Aurantiochytrium sp. KRS101. | 2011 | Appl. Biochem. Biotechnol. | pmid:21424706 |
| Farias SE et al. | Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. | 2011 | J Trauma | pmid:21427623 |
| Makhoul Z et al. | Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. | 2011 | Eur J Clin Nutr | pmid:21427737 |
| Abelsohn A et al. | Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years. | 2011 | Can Fam Physician | pmid:21322285 |
| Wagner K et al. | Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21854866 |
| Park CK et al. | Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. | 2011 | J. Neurosci. | pmid:22171045 |
| Zúñiga J et al. | N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. | 2011 | PLoS ONE | pmid:22174823 |
| Song KS et al. | Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. | 2011 | Pancreatology | pmid:22213040 |
| Meldrum SJ et al. | The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. | 2011 | Contemp Clin Trials | pmid:21718804 |
| D'Alessandro A et al. | Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. | 2011 | J Proteomics | pmid:21723426 |
| Glew RH et al. | Low docosahexaenoic acid in the diet and milk of American Indian women in New Mexico. | 2011 | J Am Diet Assoc | pmid:21515123 |
| Maki KC et al. | Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21297494 |
| Courville AB et al. | Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. | 2011 | Br. J. Nutr. | pmid:21521543 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Ferreira M et al. | Effect of the nutritional status of semi-continuous microalgal cultures on the productivity and biochemical composition of Brachionus plicatilis. | 2011 | Mar. Biotechnol. | pmid:21487686 |
| Smithers LG et al. | Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. | 2011 | Am. J. Clin. Nutr. | pmid:21490140 |
| Yalçın S et al. | Effect of maternal corticosterone on utilisation of residual yolk sac fatty acids by developing broiler embryo. | 2011 | Br. Poult. Sci. | pmid:21491250 |
| Morris MC and Tangney CC | A potential design flaw of randomized trials of vitamin supplements. | 2011 | JAMA | pmid:21467288 |
| Sun C et al. | DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. | 2011 | Mol. Biol. Rep. | pmid:20383747 |
| Hutchins HL et al. | Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. | 2011 | J. Nutr. Biochem. | pmid:20951563 |
| Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
| Arshad A et al. | Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. | 2011 | Br. J. Nutr. | pmid:21745426 |
| Recchiuti A et al. | MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. | 2011 | FASEB J. | pmid:20956612 |
| Basselin M et al. | Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20664612 |
| Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
| Weise C et al. | Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. | 2011 | Pediatr Allergy Immunol | pmid:21294775 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
| Barden A et al. | The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. | 2011 | Free Radic. Res. | pmid:21235285 |
| Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
| Imhoff-Kunsch B et al. | Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. | 2011 | J. Nutr. | pmid:21178076 |
| Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
| Klein CM and Jenkins TC | Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. | 2011 | J. Dairy Sci. | pmid:21854940 |
| Wang F et al. | Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. | 2011 | Curr. Mol. Med. | pmid:21663587 |
| Lima-Garcia JF et al. | The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. | 2011 | Br. J. Pharmacol. | pmid:21418187 |
| Xu ZZ and Ji RR | Resolvins are potent analgesics for arthritic pain. | 2011 | Br. J. Pharmacol. | pmid:21418190 |
| Galicia-Connolly EZ et al. | Complementary, holistic, and integrative medicine: therapies for learning disabilities. | 2011 | Pediatr Rev | pmid:21285298 |
| Nobili V et al. | Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. | 2011 | Arch. Dis. Child. | pmid:21233083 |
| Aarsetoey H et al. | Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. | 2011 | Lipids | pmid:21234696 |
| Salm P et al. | Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and arachidonic acid in plasma by high-performance liquid chromatography-tandem mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:20737653 |
| Ozsoy O et al. | The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. | 2011 | Neurotox Res | pmid:21234736 |
| McNamara RK | Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? | 2011 | Schizophr. Res. | pmid:21276713 |
| Taoka Y et al. | Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304. | 2011 | J. Biosci. Bioeng. | pmid:21216665 |
| Majkova Z et al. | Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21130106 |
| Valera B et al. | Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. | 2011 | Int J Circumpolar Health | pmid:21329579 |
| Furuhjelm C et al. | Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. | 2011 | Pediatr Allergy Immunol | pmid:21332799 |
| Sriram K | Confusion between gamma-linolenic acid and gamma-linoleic acid. | 2011 | Crit. Care Med. | pmid:22094528 |
| Scott SD et al. | Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. | 2011 | Enzyme Microb. Technol. | pmid:22112910 |
| Liu C and Cai WX | [Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice]. | 2011 | Fa Yi Xue Za Zhi | pmid:21604451 |