DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Teague WE et al. | Polyunsaturated lipids in membrane fusion events. | 2002 | Cell. Mol. Biol. Lett. | pmid:12097942 |
| Barros MF et al. | Cord blood essential fatty acid and alpha-tocopherol in full-term newborns in a Northeast Brazil area. | 2002 | Int J Vitam Nutr Res | pmid:12098883 |
| Hibbeln JR | Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. | 2002 | J Affect Disord | pmid:12103448 |
| Minda H et al. | Systematic review of fatty acid composition of plasma phospholipids of venous cord blood in full-term infants. | 2002 | Eur J Nutr | pmid:12111050 |
| Haubner LY et al. | Maternal dietary docosahexanoic acid content affects the rat pup auditory system. | 2002 | Brain Res. Bull. | pmid:12121805 |
| Shmeeda H et al. | Heat acclimation in rats: modulation via lipid polyunsaturation. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12121852 |
| Murayama K et al. | Fish oil (polyunsaturated fatty acid) prevents ischemic-induced injury in the mammalian retina. | 2002 | Exp. Eye Res. | pmid:12126941 |
| Fam SS et al. | Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. | 2002 | J. Biol. Chem. | pmid:12133837 |
| Benito Fernández J et al. | [The influence of human milk and various artificial formulae commercially available in Spain on the fatty acid status of infants in the first two months of life]. | 2002 | An. Esp. Pediatr. | pmid:12139873 |
| Diaz O et al. | The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts. | 2002 | J. Biol. Chem. | pmid:12140281 |
| Hansen RA et al. | Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. | 2002 Jul-Aug | J. Vet. Intern. Med. | pmid:12141309 |
| Nestel P et al. | The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12145002 |
| Jeffrey BG et al. | n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147619 |
| Armstrong D et al. | Preparation of microspheres and incorporation of lipid hydroperoxide for sustained release studies. | 2002 | Methods Mol. Biol. | pmid:12152211 |
| Akbar M and Kim HY | Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. | 2002 | J. Neurochem. | pmid:12153489 |
| Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
| Jensen CL and Heird WC | Lipids with an emphasis on long-chain polyunsaturated fatty acids. | 2002 | Clin Perinatol | pmid:12168241 |
| RVitelli M et al. | Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes. | 2002 | Life Sci. | pmid:12175705 |
| Turner ND et al. | Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis. | 2002 | Cancer Lett. | pmid:12183072 |
| Berger A et al. | Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression. | 2002 | Genome Biol. | pmid:12184799 |
| Sugimoto Y et al. | Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. | 2002 | Biol. Pharm. Bull. | pmid:12186415 |
| Pilitsis JG et al. | Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. | 2002 | J. Neurosurg. | pmid:12186453 |
| pmid:12195273 | ||||
| Cheruku SR et al. | Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning. | 2002 | Am. J. Clin. Nutr. | pmid:12198007 |
| Kimura S et al. | Docosahexaenoic acid attenuated hypertension and vascular dementia in stroke-prone spontaneously hypertensive rats. | 2002 Sep-Oct | Neurotoxicol Teratol | pmid:12200199 |
| Doolan GK et al. | Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK. | 2002 | FASEB J. | pmid:12206993 |
| Wallis JG et al. | Polyunsaturated fatty acid synthesis: what will they think of next? | 2002 | Trends Biochem. Sci. | pmid:12217522 |
| Weiler HA and Fitzpatrick-Wong SC | Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. | 2002 | J. Nutr. | pmid:12221227 |
| Minda H et al. | Effect of different types of feeding on fatty acid composition of erythrocyte membrane lipids in full-term infants. | 2002 | Acta Paediatr. | pmid:12222708 |
| Fernandes MX et al. | Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane. | 2002 | Biochim. Biophys. Acta | pmid:12225849 |
| Arsenov DV et al. | [Effects of complexes of alpha-fetoprotein and amphiphilic docosaenoic acid derivatives on the humoral immune response in C57BL/6 mice]. | 2002 May-Jun | Eksp Klin Farmakol | pmid:12227097 |
| Yang P et al. | Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. | 2002 | Anal. Biochem. | pmid:12234478 |
| Goel DP et al. | Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12234824 |
| Innis SM and Dyer RA | Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. | 2002 | J. Lipid Res. | pmid:12235185 |
| Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
| Calder PC | Dietary modification of inflammation with lipids. | 2002 | Proc Nutr Soc | pmid:12296294 |
| Chapkin RS et al. | Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures. | 2002 | Clin. Exp. Immunol. | pmid:12296847 |
| Burdge GC et al. | Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain. | 2002 | Br. J. Nutr. | pmid:12323087 |
| Ghys A et al. | Red blood cell and plasma phospholipid arachidonic and docosahexaenoic acid levels at birth and cognitive development at 4 years of age. | 2002 | Early Hum. Dev. | pmid:12324186 |
| Williard DE et al. | Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324227 |
| Martin RE et al. | Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324228 |
| Krasevec JM et al. | Maternal and infant essential fatty acid status in Havana, Cuba. | 2002 | Am. J. Clin. Nutr. | pmid:12324298 |
| Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | 2002 | Mol. Vis. | pmid:12355064 |
| Sergeeva M et al. | Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation. | 2002 | J. Neurochem. | pmid:12358772 |
| AbuGhazaleh AA et al. | Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. | 2002 | J. Dairy Sci. | pmid:12362459 |
| Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
| Hulbert AJ et al. | Acyl composition of muscle membranes varies with body size in birds. | 2002 | J. Exp. Biol. | pmid:12364409 |
| Mathews SA et al. | Comparison of triglycerides and phospholipids as supplemental sources of dietary long-chain polyunsaturated fatty acids in piglets. | 2002 | J. Nutr. | pmid:12368399 |
| Acar N et al. | Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. | 2002 | J. Nutr. | pmid:12368410 |
| Brzustowicz MR et al. | Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. | 2002 | Biochemistry | pmid:12369842 |