DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Landmark K et al. | Effects of fish oil, nifedipine and their combination on blood pressure and lipids in primary hypertension. | 1993 | J Hum Hypertens | pmid:8450517 |
| Oskarsson HJ et al. | Dietary fish oil supplementation reduces myocardial infarct size in a canine model of ischemia and reperfusion. | 1993 | J. Am. Coll. Cardiol. | pmid:8459088 |
| Ikeda I et al. | Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats. | 1993 | Life Sci. | pmid:8464336 |
| Baybutt RC et al. | The effects of dietary fish oil on alveolar type II cell fatty acids and lung surfactant phospholipids. | 1993 | Lipids | pmid:8464346 |
| Shikano M et al. | Effect of docosahexaenoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-1. | 1993 | J. Immunol. | pmid:8468486 |
| Lin DS et al. | Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. | 1993 | J. Lipid Res. | pmid:8468532 |
| Tatò F et al. | Effects of fish oil concentrate on lipoproteins and apolipoproteins in familial combined hyperlipidemia. | 1993 | Clin Investig | pmid:8471818 |
| Wang H et al. | N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes. | 1993 | J. Clin. Invest. | pmid:8473489 |
| Bjerve KS et al. | Omega-3 fatty acids: essential fatty acids with important biological effects, and serum phospholipid fatty acids as markers of dietary omega 3-fatty acid intake. | 1993 | Am. J. Clin. Nutr. | pmid:8475898 |
| Hoffman DR et al. | Effects of supplementation with omega 3 long-chain polyunsaturated fatty acids on retinal and cortical development in premature infants. | 1993 | Am. J. Clin. Nutr. | pmid:8475899 |
| Makrides M et al. | Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. | 1993 | Pediatr. Res. | pmid:8479826 |
| Thien FC et al. | Dietary fish oil effects on seasonal hay fever and asthma in pollen-sensitive subjects. | 1993 | Am. Rev. Respir. Dis. | pmid:8484622 |
| Greenfield SM et al. | A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. | 1993 | Aliment. Pharmacol. Ther. | pmid:8485269 |
| Püttmann M et al. | Fast HPLC determination of serum free fatty acids in the picomole range. | 1993 | Clin. Chem. | pmid:8485873 |
| Cunnane SC et al. | Detection of [U-13C]eicosapentaenoic acid in rat liver lipids using 13C nuclear magnetic resonance spectroscopy. | 1993 | Lipids | pmid:8487618 |
| Yasugi T et al. | The influence of docosahexaenoic acid loading on stroke-prone spontaneously hypertensive rats. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8489157 |
| Hinds A and Sanders TA | The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse. | 1993 | Br. J. Nutr. | pmid:8489998 |
| Pascale AW et al. | Omega-3 fatty acid modification of membrane structure and function. II. Alteration by docosahexaenoic acid of tumor cell sensitivity to immune cytolysis. | 1993 | Nutr Cancer | pmid:8502585 |
| Deslypere JP et al. | Stability of n-3 fatty acids in human fat tissue aspirates during storage. | 1993 | Am. J. Clin. Nutr. | pmid:8503357 |
| Krokan HE et al. | The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. | 1993 | Biochim. Biophys. Acta | pmid:8504143 |
| Takahashi M et al. | Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid. | 1993 | Cancer Res. | pmid:8504420 |
| Gamen S et al. | mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytotoxicity. | 1995 | FEBS Lett. | pmid:8521957 |
| Hayashi M et al. | The effects of long-term treatment with eicosapentaenoic acid and docosahexaenoic acid on hypoxia/rexoygenation injury of isolated cardiac cells in adult rats. | 1995 | J. Mol. Cell. Cardiol. | pmid:8523462 |
| Crespo-Armas A et al. | Changes produced by experimental hypothyroidism in fibre type composition and mitochondrial properties of rat slow and fast twitch muscles. | 1994 | Acta Cient. Venez. | pmid:8525758 |
| Vallette G et al. | Unsaturated fatty acids synergistically enhance glucocorticoid-induced gene expression. | 1995 | Cell. Signal. | pmid:8527300 |
| Jenski LJ et al. | Omega-3 fatty acid-containing liposomes in cancer therapy. | 1995 | Proc. Soc. Exp. Biol. Med. | pmid:8539260 |
| van Houwelingen AC et al. | Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy. | 1995 | Br. J. Nutr. | pmid:8541278 |
| Ikeda I et al. | Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. | 1995 | Biochim. Biophys. Acta | pmid:8541338 |
| Hornstra G et al. | Essential fatty acids in pregnancy and early human development. | 1995 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:8549848 |
| Salem N et al. | Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8552667 |
| Appel MJ and Woutersen RA | Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats. | 1996 | Br. J. Cancer | pmid:8554980 |
| Pepe S and McLennan PL | Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. | 1996 | J. Nutr. | pmid:8558320 |
| Girón MD et al. | The short-term effect of dietary fats on the brain fatty acid composition in rats. | 1995 | Arch. Physiol. Biochem. | pmid:8574769 |
| Nakamura T et al. | Serum fatty acid composition in normal Japanese and its relationship with dietary fish and vegetable oil contents and blood lipid levels. | 1995 | Ann. Nutr. Metab. | pmid:8585694 |
| Achtani C et al. | Effect of MaxEPA (fish oil) on lipoproteins and its receptors in hypercholesterolemic rabbits. | 1995 | Biochem. Mol. Biol. Int. | pmid:8595389 |
| Grynberg A et al. | Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenoceptor responsiveness and mechanism. | 1995 | J. Mol. Cell. Cardiol. | pmid:8596201 |
| Christensen JH et al. | Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. | 1996 | BMJ | pmid:8597736 |
| Hughes DA et al. | (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. | 1996 | J. Nutr. | pmid:8598544 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. | 1996 | Scand. J. Immunol. | pmid:8602457 |
| Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. | 1996 | J. Clin. Invest. | pmid:8613538 |
| Shashoua VE and Hesse GW | N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. | 1996 | Life Sci. | pmid:8614292 |
| Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
| Pageaux JF et al. | Biogenesis and metabolic fate of docosahexaenoic and arachidonic acids in rat uterine stromal cells in culture. | 1996 | Arch. Biochem. Biophys. | pmid:8615684 |
| Serhiienko OO | [The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)]. | 1995 May-Jun | Lik. Sprava | pmid:8630815 |
| Engler MB and Engler MM | Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. | 1996 | Gerontology | pmid:8641598 |
| Khair-El-Din T et al. | Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. | 1996 | J. Exp. Med. | pmid:8642266 |
| Prisco D et al. | Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. | 1996 | Am. J. Clin. Nutr. | pmid:8644688 |
| Makrides M et al. | Is dietary docosahexaenoic acid essential for term infants? | 1996 | Lipids | pmid:8649228 |
| Weisinger HS et al. | The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. | 1996 | Lipids | pmid:8649236 |
| Carlson SE and Werkman SH | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. | 1996 | Lipids | pmid:8649239 |