DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Teague H et al. | Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. | 2013 | Immunology | pmid:23373457 |
| Soubias O and Gawrisch K | Rhodopsin-lipid interactions studied by NMR. | 2013 | Meth. Enzymol. | pmid:23374188 |
| Ishida T et al. | Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375839 |
| Bazan NG et al. | Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107502 |
| Herba CM et al. | Breastfeeding and early brain development: the Generation R study. | 2013 | Matern Child Nutr | pmid:23167730 |
| Rovito D et al. | Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23168911 |
| Sato SB et al. | Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. | 2013 | Biochim. Biophys. Acta | pmid:23085420 |
| Poudyal H et al. | Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23026492 |
| Dallaire R et al. | Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. | 2013 | Environ Int | pmid:23422685 |
| Liu J et al. | Screening and characterization of Isochrysis strains and optimization of culture conditions for docosahexaenoic acid production. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23423326 |
| Metherel AH et al. | Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. | 2013 | Lipids Health Dis | pmid:23425563 |
| Miyata J et al. | Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:23006546 |
| Gladyshev MI et al. | Production of EPA and DHA in aquatic ecosystems and their transfer to the land. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500063 |
| Zhuang W et al. | Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. | 2013 | J Cardiovasc Transl Res | pmid:22993129 |
| Lu Y et al. | Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. | 2013 | Neuroscience | pmid:23500096 |
| Mozaffari-Khosravi H et al. | Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. | 2013 | Eur Neuropsychopharmacol | pmid:22910528 |
| Cardenia V et al. | Health-related lipids components of sardine muscle as affected by photooxidation. | 2013 | Food Chem. Toxicol. | pmid:23500769 |
| Saha SS and Ghosh M | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. | 2013 | Nutrition | pmid:23422533 |
| Rahman MM et al. | DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. | 2013 | Breast Cancer Res. Treat. | pmid:24062211 |
| Fagan P and Wijesundera C | Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. | 2013 | J Sep Sci | pmid:23559561 |
| Jans JJ et al. | Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. | 2013 | Mol. Genet. Metab. | pmid:23562298 |
| Faxén-Irving G et al. | Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. | 2013 | J. Alzheimers Dis. | pmid:23563245 |
| Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
| Guo B et al. | Identification and heterologous expression of a Δ4-fatty acid desaturase gene from Isochrysis sphaerica. | 2013 | J. Microbiol. Biotechnol. | pmid:23851273 |
| Markhus MW et al. | Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. | 2013 | PLoS ONE | pmid:23844041 |
| Singh A et al. | Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. | 2013 | PLoS ONE | pmid:23844124 |
| Muldoon MF et al. | Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. | 2013 | J. Nutr. | pmid:23884386 |
| Meyer BJ et al. | Improvement of major depression is associated with increased erythrocyte DHA. | 2013 | Lipids | pmid:23733443 |
| Zawadzki M et al. | Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. | 2013 | Mar Drugs | pmid:23739042 |
| Morel PC et al. | Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. | 2013 | Meat Sci. | pmid:23739265 |
| Laird BD et al. | Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids. | 2013 | J. Nutr. | pmid:23616502 |
| Sala-Vila A et al. | Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. | 2013 | J. Nutr. Biochem. | pmid:23618530 |
| Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
| Johnston DT et al. | Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. | 2013 | Nutr Neurosci | pmid:22748167 |
| Wang Y et al. | DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. | 2013 | Biomed Res Int | pmid:23984342 |
| Chien KL et al. | Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort. | 2013 | Atherosclerosis | pmid:23958266 |
| Santos VC et al. | Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23239683 |
| Das UN | Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. | 2013 | Nutrition | pmid:23911220 |
| Köhnke T et al. | Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. | 2013 | Biomed Res Int | pmid:24083240 |
| Flock MR et al. | Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. | 2013 | J Am Heart Assoc | pmid:24252845 |
| Alicandro G et al. | A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266209 |
| Fenton JI and McCaskey SJ | Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266210 |
| Rogers LK et al. | DHA supplementation: current implications in pregnancy and childhood. | 2013 | Pharmacol. Res. | pmid:23266567 |
| Otsuka R et al. | Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. | 2013 | Lipids | pmid:23389403 |
| Cunnane SC et al. | Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22575581 |
| Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
| Aliche-Djoudi F et al. | A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. | 2013 | Food Chem. Toxicol. | pmid:23907024 |
| Thom VT et al. | Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. | 2013 | Cell. Physiol. Biochem. | pmid:23988425 |
| Gupta A et al. | Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23990167 |
| Satkunendrarajah K and Fehlings MG | Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. | 2013 | Exp. Neurol. | pmid:23994716 |