DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Goustard-Langelier B et al. | Phospholipid incorporation and metabolic conversion of n-3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line. | 2000 | J. Neurosci. Res. | pmid:10820439 |
| Weber P and Raederstorff D | Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review. | 2000 | Nutr Metab Cardiovasc Dis | pmid:10812585 |
| Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
| Valk EE and Hornstra G | Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. | 2000 | Int J Vitam Nutr Res | pmid:10804454 |
| Amamoto T et al. | [Relationship between hippocampal arachidonic acid content and induction of LTP in aged rats]. | 1999 | Nihon Shinkei Seishin Yakurigaku Zasshi | pmid:10803212 |
| Yano M et al. | Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. | 2000 | J. Nutr. | pmid:10801904 |
| Itokazu N et al. | Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. | 2000 | Brain Res. | pmid:10799687 |
| Tsukada H et al. | Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys. | 2000 | Brain Res. | pmid:10799683 |
| Smit EN et al. | Fish oil supplementation improves docosahexaenoic acid status of malnourished infants. | 2000 | Arch. Dis. Child. | pmid:10799425 |
| Mori TA et al. | Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. | 2000 | Am. J. Clin. Nutr. | pmid:10799369 |
| Bechoua S et al. | Protective effect of docosahexaenoic acid against hydrogen peroxide-induced oxidative stress in human lymphocytes. | 1999 | Biochem. Pharmacol. | pmid:10796072 |
| Greatrex JC et al. | Scotopic sensitivity in dyslexia and requirements for DHA supplementation. | 2000 | Lancet | pmid:10791530 |
| Meluzzi A et al. | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. | 2000 | Poult. Sci. | pmid:10780651 |
| MartÃnez M et al. | [Treatment of generalized peroxisomal disorders with docosahexaenoic acid ethyl ether]. | 1999 | Rev Neurol | pmid:10778491 |
| Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
| Onuki Y et al. | In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption. | 2000 | Int J Pharm | pmid:10767564 |
| Xi S et al. | Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765974 |
| Ogilvie GK et al. | Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. | 2000 | Cancer | pmid:10760770 |
| Kim HY and Hamilton J | Accumulation of docosahexaenoic acid in phosphatidylserine is selectively inhibited by chronic ethanol exposure in C-6 glioma cells. | 2000 | Lipids | pmid:10757550 |
| Gaposchkin DP et al. | Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. | 2000 | Lipids | pmid:10757549 |
| Conquer JA et al. | Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. | 2000 | Lipids | pmid:10757545 |
| Gross EA et al. | G239T mutation in Repeat 1 of human IRBP: possible implications for more than one binding site in a single repeat. | 2000 | Mol. Vis. | pmid:10756181 |
| Birch EE et al. | A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. | 2000 | Dev Med Child Neurol | pmid:10755457 |
| Sametz W et al. | Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). | 2000 | Pharmacology | pmid:10754452 |
| Igarashi M and Miyazawa T | Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753678 |
| Puri BK et al. | Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. | 2000 Jan-Feb | Int. J. Clin. Pract. | pmid:10750263 |
| Brooks SL et al. | Mothers, infants, and DHA. Implications for nursing practice. | 2000 Mar-Apr | MCN Am J Matern Child Nurs | pmid:10748583 |
| Surai PF et al. | Designer egg evaluation in a controlled trial. | 2000 | Eur J Clin Nutr | pmid:10745280 |
| Thakkar RR et al. | Docosahexaenoic acid reverses cyclosporin A-induced changes in membrane structure and function. | 2000 | Biochim. Biophys. Acta | pmid:10742598 |
| Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
| Grande JP et al. | Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo. | 2000 | Kidney Int. | pmid:10720955 |
| Hempenius RA et al. | Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats. | 2000 Feb-Mar | Food Chem. Toxicol. | pmid:10717353 |
| Hansen J et al. | Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. | 2000 | Thromb. Res. | pmid:10713313 |
| Yasuda S et al. | Dietary docosahexaenoic acid enhances ferric nitrilotriacetate-induced oxidative damage in mice but not when additional alpha-tocopherol is supplemented. | 1999 | Free Radic. Res. | pmid:10711790 |
| Madsen L et al. | EPA and DHA possess different metabolic properties. | 1999 | Adv. Exp. Med. Biol. | pmid:10709658 |
| Berge K et al. | Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture. | 1999 | Adv. Exp. Med. Biol. | pmid:10709646 |
| Berge RK et al. | Hypolipidemic 3-thia fatty acids. Fatty acid oxidation and ketogenesis in rat liver under proliferation of mitochondria and peroxisomes. | 1999 | Adv. Exp. Med. Biol. | pmid:10709636 |
| Yamashita K et al. | Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. | 2000 | Biofactors | pmid:10705949 |
| Wang L et al. | Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women. | 2000 | Pediatr Int | pmid:10703228 |
| Volker DH et al. | The eicosapentaenoic to docosahexaenoic acid ratio of diets affects the pathogenesis of arthritis in Lew/SSN rats. | 2000 | J. Nutr. | pmid:10702585 |
| Negretti N et al. | Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. | 2000 | J. Physiol. (Lond.) | pmid:10699081 |
| Cunnane SC et al. | Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. | 2000 | Lipids | pmid:10695931 |
| Baur LA et al. | Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding. | 2000 | Lipids | pmid:10695927 |
| Tomobe YI et al. | Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. | 2000 | Lipids | pmid:10695925 |
| Ghebremeskel K et al. | Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood. | 2000 | Eur J Clin Nutr | pmid:10694772 |
| Reich EE et al. | Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. | 2000 | Biochemistry | pmid:10694406 |
| Zuijdgeest-van Leeuwen SD et al. | Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions. | 1999 | Br. J. Nutr. | pmid:10690163 |
| Watanabe T and Kuroda Y | The effect of a newly developed ointment containing eicosapentaenoic acid and docosahexaenoic acid in the treatment of atopic dermatitis. | 1999 | J. Med. Invest. | pmid:10687312 |
| Arterburn LM et al. | A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO oil). | 2000 | Food Chem. Toxicol. | pmid:10685012 |
| Sawazaki S et al. | The effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled study. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10683816 |