DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Igarashi M et al. | Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. | 2012 | J. Neurochem. | pmid:22117540 |
| Lim SJ et al. | Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. | 2012 | Oncol. Rep. | pmid:22395735 |
| Sørensen IM et al. | Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. | 2012 | Diabetes Metab. Res. Rev. | pmid:22396195 |
| Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
| Noreen EE and Brandauer J | The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. | 2012 | J Complement Integr Med | pmid:23104856 |
| Kautharapu KB and Jarboe LR | Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). | 2012 | J. Bacteriol. | pmid:23105048 |
| Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
| Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
| Jackson PA et al. | Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. | 2012 | Biol Psychol | pmid:22020134 |
| An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
| Li N et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22020559 |
| Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
| Samaee SM and Estévez A | Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. | 2012 | J Exp Zool A Ecol Genet Physiol | pmid:22021057 |
| Macášek J et al. | Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. | 2012 | Nutr Cancer | pmid:23061902 |
| Pineda-Peña EA et al. | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. | 2012 | Eur. J. Pharmacol. | pmid:23063544 |
| Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
| Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
| Molloy C et al. | Docosahexaenoic acid and visual functioning in preterm infants: a review. | 2012 | Neuropsychol Rev | pmid:23065239 |
| Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
| Deckelbaum RJ et al. | Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. | 2012 | J. Nutr. | pmid:22323767 |
| Harden CJ et al. | Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. | 2012 | Br. J. Nutr. | pmid:22313587 |
| Komatsuzaki N and Shima J | Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22313752 |
| Tan Z et al. | Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. | 2012 | Food Chem | pmid:23442661 |
| Kisos H et al. | Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. | 2012 | PLoS ONE | pmid:23077527 |
| Pan XX et al. | Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. | 2012 | J. Agric. Food Chem. | pmid:22934819 |
| Zhao M et al. | Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. | 2012 | J. Nutr. | pmid:22955512 |
| Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
| Cortie CH and Else PL | Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. | 2012 | Int J Mol Sci | pmid:23203135 |
| Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
| van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
| Odusanwo O et al. | Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22237406 |
| Stein AD et al. | Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. | 2012 | J. Nutr. | pmid:22739364 |
| Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
| Han CY et al. | NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. | 2012 | J. Biol. Chem. | pmid:22287546 |
| Scheltens P et al. | Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. | 2012 | J. Alzheimers Dis. | pmid:22766770 |
| Moreno-Indias I et al. | Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. | 2012 | J. Anim. Sci. | pmid:22665635 |
| Holly LT et al. | Dietary therapy to promote neuroprotection in chronic spinal cord injury. | 2012 | J Neurosurg Spine | pmid:22735048 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
| da Silva Acosta D et al. | Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. | 2012 | Fish Physiol. Biochem. | pmid:22451341 |
| Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Bianchini F et al. | 22Â :Â 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. | 2012 | Br. J. Nutr. | pmid:22390897 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
| Drzymała-Czyż S et al. | Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. | 2012 | Folia Histochem. Cytobiol. | pmid:22532147 |
| Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
| Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
| Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |
| Aisen PS et al. | Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. | 2012 | Cold Spring Harb Perspect Med | pmid:22393531 |