DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
| Bernhard W et al. | Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. | 2014 | Eur J Nutr | pmid:24464176 |
| Schuster GU et al. | Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24134486 |
| Maitin V et al. | Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. | 2014 | J. Lipid Res. | pmid:24136824 |
| Katakura M et al. | Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2014 | Molecules | pmid:24642910 |
| Browning LM et al. | Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. | 2014 | J. Nutr. | pmid:24647395 |
| Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
| Hoogeveen EK et al. | Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. | 2014 | Clin J Am Soc Nephrol | pmid:25104273 |
| Bispo P et al. | Preparation of triacylglycerols rich in omega-3 fatty acids from sardine oil using a Rhizomucor miehei lipase: focus in the EPA/DHA ratio. | 2014 | Appl. Biochem. Biotechnol. | pmid:24293255 |
| Skender B et al. | DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. | 2014 | Biochim. Biophys. Acta | pmid:24953781 |
| Zhao Z and Zlokovic BV | Blood-brain barrier: a dual life of MFSD2A? | 2014 | Neuron | pmid:24853933 |
| Hoffman DR et al. | Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial. | 2014 | JAMA Ophthalmol | pmid:24805262 |
| Shimamoto C et al. | Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. | 2014 | Hum. Mol. Genet. | pmid:25027319 |
| Balas L et al. | Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. | 2014 | Biochimie | pmid:24262603 |
| Siddesha JM et al. | Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. | 2014 | Cell. Signal. | pmid:24447911 |
| Shao Z et al. | Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24458713 |
| Steffens JP et al. | Testosterone regulates bone response to inflammation. | 2014 | Horm. Metab. Res. | pmid:24526374 |
| Maffei S et al. | Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome. | 2014 | Mediators Inflamm. | pmid:24526821 |
| Vandal M et al. | Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. | 2014 | J. Neurochem. | pmid:24345162 |
| Prostek A et al. | The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. | 2014 | Lipids Health Dis | pmid:24387137 |
| Yaxin W et al. | Resolvin D1 attenuates lipopolysaccharide induced acute lung injury through CXCL-12/CXCR4 pathway. | 2014 | J. Surg. Res. | pmid:24387839 |
| Shaikh NA et al. | Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. | 2014 | Mol. Cell. Biochem. | pmid:25185754 |
| Leigh NJ et al. | Expression of resolvin D1 biosynthetic pathways in salivary epithelium. | 2014 | J. Dent. Res. | pmid:24389810 |
| O'Connor-Robison CI et al. | The impact of dietary long-chain polyunsaturated fatty acids on bone and cartilage in gilts and sows. | 2014 | J. Anim. Sci. | pmid:25184850 |
| Wójcik C et al. | Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. | 2014 | J. Cell. Mol. Med. | pmid:24834523 |
| Saito H | Lipid characteristics of five epinephelinae fishes, Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti, in the Coral Reef. | 2014 | J Oleo Sci | pmid:24717545 |
| Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
| Harden CJ et al. | Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. | 2014 | Nutr Res | pmid:24418242 |
| Asai M et al. | [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. | 2014 | Nippon Yakurigaku Zasshi | pmid:24420133 |
| Jin M et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. | 2014 | J Med Food | pmid:24460246 |
| Chen MY et al. | Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. | 2014 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:24444393 |
| Nozue T et al. | Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study. | 2014 | Cardiovasc Diabetol | pmid:24410834 |
| Freund Levi Y et al. | Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. | 2014 | J. Intern. Med. | pmid:24410954 |
| Russell CD and Schwarze J | The role of pro-resolution lipid mediators in infectious disease. | 2014 | Immunology | pmid:24400794 |
| Patterson AC et al. | The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. | 2014 | Br. J. Nutr. | pmid:23920312 |
| Ciaccio CE and Girdhar M | Effect of maternal ω3 fatty acid supplementation on infant allergy. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24565593 |
| von Schacky C | Omega-3 index and cardiovascular health. | 2014 | Nutrients | pmid:24566438 |
| Nehra D et al. | Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? | 2014 | J. Surg. Res. | pmid:24576779 |
| Abdel-Dayem MA et al. | Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. | 2014 | Drugs R D | pmid:24733439 |
| Rutkowsky JM et al. | Acylcarnitines activate proinflammatory signaling pathways. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24760988 |
| Zhao H et al. | Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. | 2014 | BMC Pulm Med | pmid:24742272 |
| DiNicolantonio JJ et al. | A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. | 2014 | Nutr Cancer | pmid:25356937 |
| Boca SM et al. | Testing multiple biological mediators simultaneously. | 2014 | Bioinformatics | pmid:24202540 |
| Peoples GE and McLennan PL | Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model. | 2014 | Br. J. Nutr. | pmid:24229620 |
| Wu A et al. | Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition. | 2014 | Neurorehabil Neural Repair | pmid:23911971 |
| Ganesan B et al. | Fortification of foods with omega-3 polyunsaturated fatty acids. | 2014 | Crit Rev Food Sci Nutr | pmid:24188235 |
| Bahety P et al. | Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. | 2014 | PLoS ONE | pmid:24587236 |
| Gregory MK et al. | Effect of dietary canola oil on long-chain omega-3 fatty acid content in broiler hearts. | 2014 | J Anim Physiol Anim Nutr (Berl) | pmid:23510129 |
| Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |
| Liu L et al. | Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets. | 2014 | J. Lipid Res. | pmid:24470588 |