DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Miyashima A et al. DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141691
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Zhang X et al. Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. 2013 Oxid Med Cell Longev pmid:24381712
Takayama M et al. Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. 2013 J Nutr Health Aging pmid:23299385
Nagai T et al. Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. 2013 J Oleo Sci pmid:24292353
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
Baum SJ EPA and DHA: distinct yet essential n-3 fatty acids. 2012 Sep-Oct J Clin Lipidol pmid:23009786
Castro González MI et al. [Renal patient's diet: Can fish be included?]. 2012 Sep-Oct Nutr Hosp pmid:23478696
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
Sanz París A et al. [Proposed profile of omega 3 fatty acids in enteral nutrition]. 2012 Nov-Dec Nutr Hosp pmid:23588426
Brown WV From the editor. 2012 Nov-Dec J Clin Lipidol pmid:23312044
Derosa G et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. 2012 Nov-Dec J Clin Lipidol pmid:23312051
Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Liang W and Chikritzhs T Does light alcohol consumption during pregnancy improve offspring's cognitive development? 2012 Med. Hypotheses pmid:21985759
Nasiri AH et al. Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. 2012 Andrologia pmid:21951061
Luxwolda MF et al. A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. 2012 Eur J Nutr pmid:21952690
Martinez-Micaelo N et al. Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. 2012 Biochem. J. pmid:21954853
Chew EY et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). 2012 Ophthalmology pmid:22840421
Hong WK et al. Growth of the oleaginous microalga Aurantiochytrium sp. KRS101 on cellulosic biomass and the production of lipids containing high levels of docosahexaenoic acid. 2012 Bioprocess Biosyst Eng pmid:21959581
Vanlint SJ and Ried K Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. 2012 Maturitas pmid:22078660
Clària J et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. 2012 J. Immunol. pmid:22844113
Lin DC et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Mol. Pharmacol. pmid:22859723
Martin CR et al. The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. 2012 Aliment. Pharmacol. Ther. pmid:22129201
Tsushima T et al. Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. 2012 J Oleo Sci pmid:22864513
Begum G et al. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. 2012 J. Neurochem. pmid:22129278
López-Alarcón M et al. Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. 2012 Nutrition pmid:22079797
Skulas-Ray AC et al. Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. 2012 Ann Behav Med pmid:22865498
Towhidi A and Parks JE Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. 2012 J. Assist. Reprod. Genet. pmid:22869241
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Whelan J et al. Effects of dietary stearidonic acid on biomarkers of lipid metabolism. 2012 J. Nutr. pmid:22279143
Wu JH et al. Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. 2012 Circulation pmid:22282329
Weylandt KH et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. 2012 Prostaglandins Other Lipid Mediat. pmid:22326554
Harlioglu AG et al. Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). 2012 Food Sci Technol Int pmid:22328124
Dawson K et al. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. 2012 J. Nutr. Biochem. pmid:21775114
Swanson D et al. Omega-3 fatty acids EPA and DHA: health benefits throughout life. 2012 Adv Nutr pmid:22332096
Vedtofte MS et al. The role of essential fatty acids in the control of coronary heart disease. 2012 Curr Opin Clin Nutr Metab Care pmid:23037902
Hofmanová J et al. Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. 2012 J. Nutr. Biochem. pmid:21775115
Berson EL et al. ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. 2012 Arch. Ophthalmol. pmid:22332205
Chang YL et al. Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. 2012 Cell Transplant pmid:21669041
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Cazzola R et al. Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. 2012 Exp. Gerontol. pmid:23000875
Tanaka T et al. Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. 2012 Lipids pmid:22411689
Hajjaji N et al. DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. 2012 Nutr Cancer pmid:23035949
Contreras GA et al. Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. 2012 J. Dairy Sci. pmid:23040031
D'Vaz N et al. Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. 2012 Pediatrics pmid:22945403
Francescato G et al. Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. 2012 Pediatr Obes pmid:22991250
Joseph MS et al. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. 2012 PLoS ONE pmid:22911773
Mas E et al. Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. 2012 Clin. Chem. pmid:22912397
Mitchell DC et al. Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. 2012 Chem. Phys. Lipids pmid:22405878
Bonatto SJ et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. 2012 Lipids pmid:22160495
Yan J et al. Improving stability and activity of cross-linked enzyme aggregates based on polyethylenimine in hydrolysis of fish oil for enrichment of polyunsaturated fatty acids. 2012 Appl. Biochem. Biotechnol. pmid:22167690
Mil-Homens D et al. The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia. 2012 FEMS Microbiol. Lett. pmid:22150831
Rupp H et al. Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". 2012 Can. J. Physiol. Pharmacol. pmid:22188440
Bang S et al. 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. 2012 Br. J. Pharmacol. pmid:21718307
Landmark K and Alm CS [Fish and omega-3 fatty acids and heart failure]. 2012 Tidsskr. Nor. Laegeforen. pmid:23736195
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Stough C et al. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. 2012 Neurobiol. Aging pmid:21531481
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Park Y et al. Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. 2012 Ann. Nutr. Metab. pmid:22776859
Rogerio AP et al. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. 2012 J. Immunol. pmid:22802419
Quiroga AD et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. 2012 Hepatology pmid:22806626
Gruber JF et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. 2012 Nutr J pmid:22747713
Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
Sirot V et al. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. 2012 Nutr Metab Cardiovasc Dis pmid:20875947
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Gladyshev MI et al. Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. 2012 J. Food Sci. pmid:23240970
Chen YJ et al. Docosahexaenoic acid suppresses the expression of FoxO and its target genes. 2012 J. Nutr. Biochem. pmid:22444500
Krishnamoorthy S et al. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. 2012 Am. J. Pathol. pmid:22449948
Gil-Sánchez A et al. Current understanding of placental fatty acid transport. 2012 Curr Opin Clin Nutr Metab Care pmid:22450774
Moon HJ et al. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. 2012 Ann. Nutr. Metab. pmid:22507833
Calandria JM et al. Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. 2012 J. Biol. Chem. pmid:22511762
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Lifschitz C New actions for old nutrients. 2012 Acta Sci Pol Technol Aliment pmid:22493160
Kwak SM et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. 2012 Arch. Intern. Med. pmid:22493407
Crawford MA and Broadhurst CL The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. 2012 Nutr Health pmid:22544773
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
Meldrum SJ et al. Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22572105
Chiang N et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. 2012 Nature pmid:22538616
Gil-Campos M and Sanjurjo Crespo P Omega 3 fatty acids and inborn errors of metabolism. 2012 Br. J. Nutr. pmid:22591887
Glover KE et al. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. 2012 J. Dairy Sci. pmid:22612917
Lopez-Huertas E The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. 2012 Br. J. Nutr. pmid:22591892
Delgado-Lista J et al. Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. 2012 Br. J. Nutr. pmid:22591894
Corsetto PA et al. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. 2012 Cell Biochem. Biophys. pmid:22622660
Serra-Majem L et al. Dietary methods and biomarkers of omega 3 fatty acids: a systematic review. 2012 Br. J. Nutr. pmid:22591904
Larqué E et al. Omega 3 fatty acids, gestation and pregnancy outcomes. 2012 Br. J. Nutr. pmid:22591905
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. 2012 Br. J. Nutr. pmid:22591907