| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li H et al. | Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. | 2013 | Biotechnol. Lett. | pmid:23386226 |
| Wang TM et al. | Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. | 2013 | Mol. Cell. Biochem. | pmid:23361365 |
| Suganuma H et al. | Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. | 2013 | Ann. Nutr. Metab. | pmid:23364132 |
| Offman E et al. | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. | 2013 | Vasc Health Risk Manag | pmid:24124374 |
| Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
| Daak AA et al. | Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24095588 |
| Faber J et al. | Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. | 2013 | Clin Nutr | pmid:23123043 |
| Hsiao HM et al. | A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. | 2013 | PLoS ONE | pmid:23484005 |
| Hoshi T et al. | Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²âº-dependent K⺠channels. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487785 |
| Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
| Poudyal H et al. | Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23026492 |
| Izquierdo MS et al. | Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. | 2013 | Br. J. Nutr. | pmid:23046500 |
| Snodgrass RG et al. | Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. | 2013 | J. Immunol. | pmid:24043885 |
| Fahrmann JF and Hardman WE | Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. | 2013 | Lipids Health Dis | pmid:23497075 |
| Moate PJ et al. | Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. | 2013 | J. Dairy Sci. | pmid:23498011 |
| Ajami M et al. | Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. | 2013 | Fundam Clin Pharmacol | pmid:22943605 |
| Ruiz-Lopez N et al. | Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. | 2013 | Metab. Eng. | pmid:23500000 |
| Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
| De Genaro P et al. | Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23580485 |
| Hudson AG et al. | Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. | 2013 | Nutr Cancer | pmid:23530640 |
| Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
| Chen J et al. | Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. | 2013 | Food Chem. Toxicol. | pmid:23590892 |
| Damsgaard CT et al. | n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. | 2013 | Br. J. Nutr. | pmid:23591057 |
| Zhang X et al. | Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. | 2013 | PLoS ONE | pmid:23840712 |
| Shin S et al. | The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. | 2013 | Biomed Res Int | pmid:23841076 |
| Baillie JK and Digard P | Influenza--time to target the host? | 2013 | N. Engl. J. Med. | pmid:23841736 |
| Dalli J et al. | Novel n-3 immunoresolvents: structures and actions. | 2013 | Sci Rep | pmid:23736886 |
| Shiraishi M et al. | Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. | 2013 | Nutr Res | pmid:23746563 |
| Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
| Thomas J et al. | Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. | 2013 | J. Nutr. Biochem. | pmid:23746933 |
| Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
| Chang G et al. | Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. | 2013 | Bioresour. Technol. | pmid:23747449 |
| Long SJ and Benton D | A double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress. | 2013 | Hum Psychopharmacol | pmid:23625531 |
| Das UN | Polyunsaturated fatty acids in heart failure. | 2013 | Circ. J. | pmid:23628915 |
| Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
| Collins MA et al. | Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | 2013 | Neurotox Res | pmid:23184649 |
| Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
| Hutchins-Wiese HL et al. | The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. | 2013 | J Nutr Health Aging | pmid:23299384 |
| Takayama M et al. | Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. | 2013 | J Nutr Health Aging | pmid:23299385 |
| Lovegrove JA and Griffin BA | The acute and long-term effects of dietary fatty acids on vascular function in health and disease. | 2013 | Curr Opin Clin Nutr Metab Care | pmid:23299700 |
| Raza Shaikh S and Brown DA | Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22464052 |
| Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
| Ishikado A et al. | 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. | 2013 | PLoS ONE | pmid:23936010 |
| Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
| de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
| Barros KV et al. | Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. | 2013 | Clin Nutr | pmid:23260750 |
| Ryu BG et al. | Use of organic waste from the brewery industry for high-density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. | 2013 | Bioresour. Technol. | pmid:23262011 |
| Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
| Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
| Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |