| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanriover G et al. | The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. | 2010 | Folia Histochem. Cytobiol. | pmid:21071351 |
| Schmidt MK and Estrada AH | ECG of the Month. Respiratory sinus arrhythmia. | 2010 | J. Am. Vet. Med. Assoc. | pmid:21034342 |
| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |
| Kaeoket K et al. | Effect of docosahexaenoic acid on quality of cryopreserved boar semen in different breeds. | 2010 | Reprod. Domest. Anim. | pmid:19090818 |
| Calder PC | Does early exposure to long chain polyunsaturated fatty acids provide immune benefits? | 2010 | J. Pediatr. | pmid:20434731 |
| Yurko-Mauro K et al. | Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. | 2010 | Alzheimers Dement | pmid:20434961 |
| Groeger AL et al. | Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. | 2010 | Nat. Chem. Biol. | pmid:20436486 |
| Frautschy SA and Cole GM | Why pleiotropic interventions are needed for Alzheimer's disease. | 2010 | Mol. Neurobiol. | pmid:20437209 |
| Suganuma H et al. | Maternal docosahexaenoic acid-enriched diet prevents neonatal brain injury. | 2010 | Neuropathology | pmid:20408962 |
| Chisari M et al. | Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions. | 2010 | Br. J. Pharmacol. | pmid:20412070 |
| McNamara RK et al. | Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. | 2010 | J Affect Disord | pmid:20413162 |
| Morley JE and Banks WA | Lipids and cognition. | 2010 | J. Alzheimers Dis. | pmid:20413879 |
| Lukiw WJ and Bazan NG | Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis. | 2010 | Mol. Neurobiol. | pmid:20414817 |
| Kaur G et al. | Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats. | 2010 | Br. J. Nutr. | pmid:19650956 |
| Kikawa KD et al. | Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid. | 2010 | Nutr Cancer | pmid:21058189 |
| Bravo E et al. | Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis. | 2010 | Lipids Health Dis | pmid:21059219 |
| Wann AK et al. | Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. | 2010 | Arthritis Res. Ther. | pmid:21059244 |
| Sottejeau Y et al. | Effect of a novel Omegacoeur®/Doluperine® nutritional combination on human embryonic kidney cell viability. | 2010 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:21062574 |
| Khairallah RJ et al. | Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20624993 |
| Olza J et al. | Influence of an eicosapentaenoic and docosahexaenoic acid-enriched enteral nutrition formula on plasma fatty acid composition and biomarkers of insulin resistance in the elderly. | 2010 | Clin Nutr | pmid:19573960 |
| Takayama F et al. | Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. | 2010 | J Oleo Sci | pmid:20625232 |
| Tamim MK et al. | Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. | 2010 | Neuropharmacology | pmid:19576910 |
| Jiménez-Gómez Y et al. | A low-fat, high-complex carbohydrate diet supplemented with long-chain (n-3) fatty acids alters the postprandial lipoprotein profile in patients with metabolic syndrome. | 2010 | J. Nutr. | pmid:20631323 |
| Graf BA et al. | Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20580213 |
| Ierna M et al. | Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. | 2010 | BMC Musculoskelet Disord | pmid:20587038 |
| Nakamoto K et al. | Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice. | 2010 | Biol. Pharm. Bull. | pmid:20522981 |
| Calder PC | Omega-3 fatty acids and inflammatory processes. | 2010 | Nutrients | pmid:22254027 |
| von Schacky C | Omega-3 Index and sudden cardiac death. | 2010 | Nutrients | pmid:22254028 |
| Mavrommatis Y et al. | Intervention with fish oil, but not with docosahexaenoic acid, results in lower levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice. | 2010 | Br. J. Nutr. | pmid:19674494 |
| Gil-Campos M and Dalmau Serra J | [Importance of docosahexaenoic acid (DHA): Functions and recommendations for its ingestion in infants]. | 2010 | An Pediatr (Barc) | pmid:20570579 |
| Huang CB and Ebersole JL | A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives. | 2010 | Mol Oral Microbiol | pmid:20331795 |
| El-Sharkawy H et al. | Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin. | 2010 | J. Periodontol. | pmid:20572767 |
| Slagsvold JE et al. | DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. | 2010 | Nutr Cancer | pmid:20574922 |
| Nath RG et al. | Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation. | 2010 | Nutr Cancer | pmid:20574923 |
| Mazer LM et al. | Docosahexaenoic acid status in females of reproductive age with maple syrup urine disease. | 2010 | J. Inherit. Metab. Dis. | pmid:20217236 |
| Ye S et al. | Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206488 |
| Lucas M et al. | n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. | 2010 | Public Health Nutr | pmid:19433004 |
| Huang LS et al. | Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. | 2010 | Lipids | pmid:20165929 |
| Liu C and Cai WX | [Progress on relationship between omega-3 polyunsaturated fatty acids and violent-aggressive behavior]. | 2010 | Fa Yi Xue Za Zhi | pmid:21425611 |
| Sharma NP et al. | Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids. | 2010 | Mol. Pharmacol. | pmid:20194532 |
| Andreasen JJ et al. | Fatty acid composition of the internal mammary artery in relation to dietary intake of marine n-3 polyunsaturated fatty acids and association with flow-mediated vasodilation. | 2010 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:20196965 |
| Arnesen H and Seljeflot I | Studies on very long chain marine n-3 fatty acids in patients with atherosclerotic heart disease with special focus on mechanisms, dosage and formulas of supplementation. | 2010 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:20196966 |
| Petersen MM et al. | Flow-mediated vasodilation and dietary intake of n-3 polyunsaturated acids in healthy subjects. | 2010 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:20196968 |
| Von Schacky C | Omega-3 fatty acids vs. cardiac disease--the contribution of the omega-3 index. | 2010 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:20196973 |
| Lee CY et al. | The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation. | 2010 | Int. J. Oncol. | pmid:20198345 |
| Cole GM and Frautschy SA | DHA may prevent age-related dementia. | 2010 | J. Nutr. | pmid:20181786 |
| Naqvi AZ et al. | n-3 fatty acids and periodontitis in US adults. | 2010 | J Am Diet Assoc | pmid:21034880 |
| Broughton KS et al. | High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. | 2010 | Nutr Res | pmid:21056289 |
| Faghiri Z and Bazan NG | PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. | 2010 | Exp. Eye Res. | pmid:20230819 |
| Chen CC et al. | Reduced brain content of arachidonic acid and docosahexaenoic acid is related to the severity of liver fibrosis. | 2010 | Dig. Dis. Sci. | pmid:20101460 |
| Moltó-Puigmartà C et al. | FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. | 2010 | Am. J. Clin. Nutr. | pmid:20335541 |
| Yan J et al. | Preparation of a crosslinked bioimprinted lipase for enrichment of polyunsaturated fatty acids from fish processing waste. | 2010 | Appl. Biochem. Biotechnol. | pmid:20101527 |
| Yee LD et al. | Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition. | 2010 | Am. J. Clin. Nutr. | pmid:20335550 |
| de Goede J et al. | Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. | 2010 | J. Nutr. | pmid:20335635 |
| Dyall SC et al. | Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. | 2010 | J. Neurosci. Res. | pmid:20336774 |
| Loukas V et al. | EPA, DHA, cholesterol and phospholipid content in Pagrus pagrus (cultured and wild), Trachinus draco and Trigla lyra from Mediterranean Sea. | 2010 | Chem. Phys. Lipids | pmid:20109443 |
| MartÃn V et al. | Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. | 2010 | J. Alzheimers Dis. | pmid:20110596 |
| Calzada C et al. | Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men. | 2010 | Atherosclerosis | pmid:19717153 |
| Vasantha Rupasinghe HP and Yasmin A | Inhibition of oxidation of aqueous emulsions of omega-3 fatty acids and fish oil by phloretin and phloridzin. | 2010 | Molecules | pmid:20110888 |
| Ramadan E et al. | Extracellular-derived calcium does not initiate in vivo neurotransmission involving docosahexaenoic acid. | 2010 | J. Lipid Res. | pmid:20388940 |
| Heidarsdottir R et al. | Does treatment with n-3 polyunsaturated fatty acids prevent atrial fibrillation after open heart surgery? | 2010 | Europace | pmid:20061328 |
| Einvik G et al. | A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at high cardiovascular risk. | 2010 | Eur J Cardiovasc Prev Rehabil | pmid:20389249 |
| Boudrault C et al. | Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. | 2010 | Neurochem. Int. | pmid:20064570 |
| Rupp H et al. | Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heart. | 2010 | Heart | pmid:19723686 |
| Saw CL et al. | Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid. | 2010 | Biochem. Pharmacol. | pmid:19744468 |
| Suphioglu C et al. | Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells. | 2010 | Br. J. Nutr. | pmid:19747413 |
| Ruiz-Rodriguez A et al. | Recent trends in the advanced analysis of bioactive fatty acids. | 2010 | J Pharm Biomed Anal | pmid:19525080 |
| Lora KR et al. | Validity and reliability of an omega-3 fatty acid food frequency questionnaire for first-generation Midwestern Latinas. | 2010 | Nutr Res | pmid:20851309 |
| Wu TC et al. | Fatty acid composition of Taiwanese human milk. | 2010 | J Chin Med Assoc | pmid:21093826 |
| Miyazawa D et al. | Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. | 2010 | Life Sci. | pmid:20837030 |
| Bang S et al. | Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. | 2010 | Br. J. Pharmacol. | pmid:20880407 |
| Kromhout D et al. | n-3 fatty acids and cardiovascular events after myocardial infarction. | 2010 | N. Engl. J. Med. | pmid:20929341 |
| Köhler A et al. | Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index. | 2010 | Br. J. Nutr. | pmid:20420756 |
| Joss-Moore LA et al. | IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation. | 2010 | Early Hum. Dev. | pmid:20869820 |
| Kang KS et al. | Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. | 2010 | PLoS ONE | pmid:20421971 |
| Picq M et al. | DHA metabolism: targeting the brain and lipoxygenation. | 2010 | Mol. Neurobiol. | pmid:20422316 |
| Maekawa M et al. | Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20951676 |
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| Johnson EJ | Age-related macular degeneration and antioxidant vitamins: recent findings. | 2010 | Curr Opin Clin Nutr Metab Care | pmid:19841580 |
| Kotani H et al. | Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. | 2010 | J. Nat. Prod. | pmid:20695472 |
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| Sethom MM et al. | Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20667702 |
| Lu DY et al. | Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids. | 2010 | Neuropsychopharmacology | pmid:20668435 |
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| Suphioglu C et al. | The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport. | 2010 | FEBS Lett. | pmid:20006607 |
| Fourches D et al. | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. | 2010 | Chem. Res. Toxicol. | pmid:20014752 |
| Rosa SM et al. | Improvement of a two-stage fermentation process for docosahexaenoic acid production by Aurantiochytrium limacinum SR21 applying statistical experimental designs and data analysis. | 2010 | Bioresour. Technol. | pmid:20015637 |
| Cederholm T and Palmblad J | Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? | 2010 | Curr Opin Clin Nutr Metab Care | pmid:20019606 |
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| Jans LA et al. | The efficacy of n-3 fatty acids DHA and EPA (fish oil) for perinatal depression. | 2010 | Br. J. Nutr. | pmid:21078211 |
| Kilari AS et al. | Long chain polyunsaturated fatty acids in mothers of preterm babies. | 2010 | J Perinat Med | pmid:20807011 |
| Lage S et al. | Fatty acid profile in patients with phenylketonuria and its relationship with bone mineral density. | 2010 | J. Inherit. Metab. Dis. | pmid:20830525 |
| Harris WS | The omega-3 index: clinical utility for therapeutic intervention. | 2010 | Curr Cardiol Rep | pmid:20809235 |
| Wang H et al. | Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid. | 2010 | Mol. Pharm. | pmid:20831192 |