| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kraffe E et al. | Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. | 2002 | Lipids | pmid:12056594 |
| Meesapyodsuk D and Qiu X | The front-end desaturase: structure, function, evolution and biotechnological use. | 2012 | Lipids | pmid:22009657 |
| Li HX et al. | Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. | 2011 | Lipids | pmid:21140236 |
| Yasuda S et al. | Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. | 1997 | Lipids | pmid:9438234 |
| Denys A et al. | Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. | 2001 | Lipids | pmid:11592732 |
| Jeffrey BG et al. | The role of docosahexaenoic acid in retinal function. | 2001 | Lipids | pmid:11724458 |
| Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
| Nauroth JM et al. | Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo. | 2010 | Lipids | pmid:20364438 |
| Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
| Grandgirard A et al. | Occurrence of geometrical isomers of eicosapentaenoic and docosahexaenoic acids in liver lipids of rats fed heated linseed oil. | 1989 | Lipids | pmid:2555649 |
| Garrido A et al. | Ingestion of high doses of fish oil increases the susceptibility of cellular membranes to the induction of oxidative stress. | 1989 | Lipids | pmid:2555651 |
| Arterburn LM et al. | Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food. | 2007 | Lipids | pmid:17713804 |
| Tardivel S et al. | Protective effects of EPA and deleterious effects of DHA on eNOS activity in Ea hy 926 cultured with lysophosphatidylcholine. | 2009 | Lipids | pmid:19190950 |
| Pasquier E et al. | Effects of delta5 polyunsaturated fatty acids of maritime pine (Pinus pinaster) seed oil on the fatty acid profile of the developing brain of rats. | 2001 | Lipids | pmid:11485159 |
| Makrides M et al. | Is dietary docosahexaenoic acid essential for term infants? | 1996 | Lipids | pmid:8649228 |
| Miller C et al. | Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. | 1989 | Lipids | pmid:2559281 |
| Weisinger HS et al. | The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. | 1996 | Lipids | pmid:8649236 |
| Carlson SE and Werkman SH | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. | 1996 | Lipids | pmid:8649239 |
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| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
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| Harris WS | n-3 fatty acids and human lipoprotein metabolism: an update. | 1999 | Lipids | pmid:10419172 |
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| Gaudette DC and Holub BJ | Albumin-bound docosahexaenoic acid and collagen-induced human platelet reactivity. | 1990 | Lipids | pmid:2139712 |
| Degrace P et al. | Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. | 1996 | Lipids | pmid:8743053 |
| McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
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| Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| De Caterina R and Libby P | Control of endothelial leukocyte adhesion molecules by fatty acids. | 1996 | Lipids | pmid:8729095 |
| Croset M et al. | In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. | 1996 | Lipids | pmid:8729104 |
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| Martinez M | Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. | 1996 | Lipids | pmid:8729110 |
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| Healy DA et al. | Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. | 2000 | Lipids | pmid:10941877 |
| Righi V et al. | EPA or DHA supplementation increases triacylglycerol, but not phospholipid, levels in isolated rat cardiomyocytes. | 2011 | Lipids | pmid:21544603 |
| Cunnane SC et al. | Detection of [U-13C]eicosapentaenoic acid in rat liver lipids using 13C nuclear magnetic resonance spectroscopy. | 1993 | Lipids | pmid:8487618 |
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| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Baybutt RC et al. | The effects of dietary fish oil on alveolar type II cell fatty acids and lung surfactant phospholipids. | 1993 | Lipids | pmid:8464346 |
| Hoffman D et al. | Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. | 2008 | Lipids | pmid:17912568 |
| Young GS et al. | Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. | 2004 | Lipids | pmid:15134138 |
| Osako K et al. | Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus. | 2006 | Lipids | pmid:17069355 |
| Yano Y et al. | Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. | 1994 | Lipids | pmid:7968276 |
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| Nøding R et al. | Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. | 1998 | Lipids | pmid:9560803 |
| Kosugi Y et al. | Esterification of polyunsaturated fatty acids by various forms of immobilized lipase from Rhizomucor miehei. | 2000 | Lipids | pmid:10858032 |
| Hirano R et al. | Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells. | 2001 | Lipids | pmid:11383693 |
| Tomobe YI et al. | Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. | 2000 | Lipids | pmid:10695925 |
| Calviello G et al. | Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. | 1997 | Lipids | pmid:9358434 |
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| Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
| Bell MV et al. | Dietary deficiency of docosahexaenoic acid impairs vision at low light intensities in juvenile herring (Clupea harengus L.). | 1995 | Lipids | pmid:7637565 |
| Mori TA et al. | New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation. | 1987 | Lipids | pmid:2828811 |
| Oikawa D et al. | Dietary CLA and DHA modify skin properties in mice. | 2003 | Lipids | pmid:12934670 |
| Huang LS et al. | Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives. | 2007 | Lipids | pmid:17879105 |
| Wainwright PE et al. | The role of n-3 essential fatty acids in brain and behavioral development: a cross-fostering study in the mouse. | 1991 | Lipids | pmid:1828850 |
| Kanazawa A et al. | Possible essentially of docosahexaenoic acid in Japanese monkey neonates: occurrence in colostrum and low biosynthetic capacity in neonate brains. | 1991 | Lipids | pmid:1828851 |
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| Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
| Clark RM and She L | Lymphatic fatty acids from rats fed human milk and formula supplemented with fish oil. | 1995 | Lipids | pmid:7564923 |
| Jenski LJ et al. | The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro. | 1998 | Lipids | pmid:9778134 |
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| Ikeda I et al. | Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. | 1998 | Lipids | pmid:9778137 |
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| Du ZY et al. | Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. | 2004 | Lipids | pmid:15669760 |
| Verlengia R et al. | Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. | 2004 | Lipids | pmid:15669761 |
| Conquer JA et al. | Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. | 2000 | Lipids | pmid:11201991 |
| Ashford A et al. | Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. | 2000 | Lipids | pmid:11202000 |
| Mayzaud P et al. | Polar and neutral lipid composition in the pelagic tunicate Pyrosoma atlanticum. | 2007 | Lipids | pmid:17541797 |
| Kelley DS et al. | Dietary docosahexaenoic acid and immunocompetence in young healthy men. | 1998 | Lipids | pmid:9655370 |
| Bitsanis D et al. | Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids. | 2006 | Lipids | pmid:16808147 |