| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Timmer-Bosscha H et al. | Influence of docosahexaenoic acid on cisplatin resistance in a human small cell lung carcinoma cell line. | 1989 | J. Natl. Cancer Inst. | pmid:2544740 |
| Mueller BA et al. | Comparative effects of omega-3 fatty acids in men and women. | 1989 | Clin Pharm | pmid:2545407 |
| Goodnight SH | The effects of omega-3 fatty acids on thrombosis and atherogenesis. | 1989 | Hematol Pathol | pmid:2545665 |
| Lee TH and Arm JP | The effects of a fish oil enriched diet on experimentally-induced and clinical asthma. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546399 |
| Hirai A et al. | Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546401 |
| Schaffer HK | Essential fatty acids and eicosanoids in cutaneous inflammation. | 1989 | Int. J. Dermatol. | pmid:2546896 |
| Steiner A et al. | Effect of fish oil on blood pressure and serum lipids in hypertension and hyperlipidaemia. | 1989 | J Hypertens Suppl | pmid:2547916 |
| Thomson AB et al. | Influence of dietary fat composition on intestinal absorption in the rat. | 1989 | Lipids | pmid:2549323 |
| Somers SD et al. | Alteration of in vitro murine peritoneal macrophage function by dietary enrichment with eicosapentaenoic and docosahexaenoic acids in menhaden fish oil. | 1989 | Cell. Immunol. | pmid:2550148 |
| Yoshino S and Ellis EF | Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550967 |
| Bégin ME et al. | Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550969 |
| Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
| Vreeken J et al. | Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. | 1989 | Thromb. Res. | pmid:2551059 |
| Vacek JL et al. | Short-term effects of omega-3 fatty acids on exercise stress test parameters, angina and lipoproteins. | 1989 | Biomed. Pharmacother. | pmid:2551411 |
| Simopoulos AP | Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. | 1989 | J. Nutr. | pmid:2564887 |
| Wetzel MG et al. | Fatty acid metabolism in normal miniature poodles and those affected with progressive rod-cone degeneration (prcd). | 1989 | Prog. Clin. Biol. Res. | pmid:2532748 |
| DiGiacomo RA et al. | Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study. | 1989 | Am. J. Med. | pmid:2536517 |
| Swann PG et al. | Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets. | 1989 | FEBS Lett. | pmid:2537230 |
| Blank ML et al. | Effects of eicosapentaenoic and docosahexaenoic acid supplements on phospholipid composition and plasmalogen biosynthesis in P388D1 cells. | 1989 | Arch. Biochem. Biophys. | pmid:2537603 |
| Hearn JA et al. | Marine lipid concentrate and atherosclerosis in the rabbit model. | 1989 | Atherosclerosis | pmid:2539167 |
| Shimokawa H and Vanhoutte PM | Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries. | 1989 | Am. J. Physiol. | pmid:2539756 |
| Lands WE | n-3 fatty acids as precursors for active metabolic substances: dissonance between expected and observed events. | 1989 | J Intern Med Suppl | pmid:2539828 |
| Karmali RA | n-3 fatty acids and cancer. | 1989 | J Intern Med Suppl | pmid:2539832 |
| Fischer S | How should we measure n-3 polyunsaturated fatty acids and their metabolites in humans? | 1989 | J Intern Med Suppl | pmid:2539833 |
| Dyerberg J and Nordøy A | Prospectives on n-3 fatty acids in medical research. | 1989 | J Intern Med Suppl | pmid:2539834 |
| Rustan AC and Drevon CA | Eicosapentaenoic acid inhibits hepatic production of very low density lipoprotein. | 1989 | J Intern Med Suppl | pmid:2539835 |
| Hirai A et al. | Eicosapentaenoic acid and adult diseases in Japan: epidemiological and clinical aspects. | 1989 | J Intern Med Suppl | pmid:2539836 |
| Sanders TA et al. | Influence of n-3 fatty acids on blood lipids in normal subjects. | 1989 | J Intern Med Suppl | pmid:2539838 |
| Bates D et al. | A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis. | 1989 | J. Neurol. Neurosurg. Psychiatr. | pmid:2540285 |
| Kim HY and Salem N | Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. | 1989 | Prostaglandins | pmid:2541468 |
| Burns CP et al. | Effect of docosahexaenoic acid on rate of differentiation of HL-60 human leukemia. | 1989 | Cancer Res. | pmid:2541901 |
| Westberg G et al. | Effect of eicosapentaenoic acid rich menhaden oil and MaxEPA on the autoimmune disease of Mrl/l mice. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2542168 |
| Anderson GJ et al. | Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick. | 1989 | J. Lipid Res. | pmid:2542425 |
| Mori TA et al. | Dietary fish oils increase serum lipids in insulin-dependent diabetics compared with healthy controls. | 1989 | Metab. Clin. Exp. | pmid:2542722 |
| Leaf DA | Omega-3 fatty acids and coronary artery disease. More than a fish tale. | 1989 | Postgrad Med | pmid:2542914 |
| Arm JP et al. | The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma. | 1989 | Am. Rev. Respir. Dis. | pmid:2543246 |
| Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
| Gupta AK et al. | Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis. | 1989 | Br. J. Dermatol. | pmid:2667615 |
| Kürkçüoğlu N and Tandoğdu R | The effect of 'MaxEPA' in the treatment of patients with Behçet's disease. | 1989 | Br. J. Dermatol. | pmid:2597640 |
| Karanian JW et al. | Cardiovascular properties of hydroxylated docosahexaenoates. | 1989 | Prog. Clin. Biol. Res. | pmid:2529554 |
| Bazan NG | The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. | 1989 | Prog. Clin. Biol. Res. | pmid:2529559 |
| Croset M and Kinsella JE | Changes in phospholipid fatty acid composition of mouse cardiac organelles after feeding graded amounts of docosahexaenoate in presence of high levels of linoleate. Effect on cardiac ATPase activities. | 1989 | Ann. Nutr. Metab. | pmid:2529810 |
| Dart AM et al. | Effects of Maxepa on serum lipids in hypercholesterolaemic subjects. | 1989 | Atherosclerosis | pmid:2692571 |
| Pilley G | Fish oil controversy. | 1989 | DICP | pmid:2718495 |
| Wechsler JG et al. | [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. | 1989 | Z Gastroenterol | pmid:2756729 |
| Dewsbury CE et al. | Topical eicosapentaenoic acid (EPA) in the treatment of psoriasis. | 1989 | Br. J. Dermatol. | pmid:2730847 |
| Chernenko GA et al. | Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2742878 |
| Bandyopadhyay GK et al. | Docosahexaenoic acid is neither synthesized nor retroconverted by the normal and tumor mouse mammary epithelial cells in primary culture. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2522001 |
| Wetzel MG et al. | Metabolic labeling of normal canine rod outer segment phospholipids in vivo and in vitro. | 1989 | Exp. Eye Res. | pmid:2522054 |
| Scott BL and Bazan NG | Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2523075 |
| Ekström B et al. | Lipolysis of polyenoic fatty acid esters of human chylomicrons by lipoprotein lipase. | 1989 | Eur. J. Clin. Invest. | pmid:2553422 |
| Hillered L and Chan PH | Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids. | 1989 | J. Neurosci. Res. | pmid:2531232 |
| Mehta JL et al. | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. | 1988 | Am. J. Med. | pmid:3276185 |
| Glauber H et al. | Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. | 1988 | Ann. Intern. Med. | pmid:3282462 |
| Blachier F et al. | Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis. | 1988 | Prostaglandins | pmid:2834771 |
| Nielsen M et al. | [3H]diazepam specific binding to rat cortex in vitro is enhanced by oleic, arachidonic and docosahexenoic acid isolated from pig brain. | 1988 | Eur. J. Pharmacol. | pmid:2836212 |
| Garg ML et al. | Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. | 1988 | J. Nutr. | pmid:2836574 |
| Goodnight SH | Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. | 1988 | Semin. Thromb. Hemost. | pmid:2845585 |
| Garg ML et al. | Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. | 1988 | Biochim. Biophys. Acta | pmid:2844278 |
| Lawson LD and Hughes BG | Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847723 |
| Wong SH and Marsh JB | Inhibition of apolipoprotein secretion and phosphatidate phosphohydrolase activity by eicosapentaenoic and docosahexaenoic acids in the perfused rat liver. | 1988 | Metab. Clin. Exp. | pmid:2848178 |
| Shimokawa H et al. | Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig. | 1988 | Br. J. Pharmacol. | pmid:2851360 |
| Mehta J et al. | Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake. | 1988 | Am. Heart J. | pmid:3142242 |
| Huang WH et al. | Control of the sodium pump by liponucleotides and unsaturated fatty acids: side-dependent effects in red cells. | 1988 | Prog. Clin. Biol. Res. | pmid:2851818 |
| Kremer JM | Omega-3 fatty acids in rheumatoid arthritis. | 1988 | Del Med J | pmid:2852607 |
| Luley C et al. | [Fatty acid composition and degree of peroxidation in fish oil and cod liver oil preparations]. | 1988 | Arzneimittelforschung | pmid:2854466 |
| Bittiner SB et al. | A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. | 1988 | Lancet | pmid:2893189 |
| Tobin A | Fish oil supplementation. | 1988 | Lancet | pmid:2896884 |
| Palmblad J and Gyllenhammar H | Effect of dietary lipids on immunity and inflammation. Review article. | 1988 | APMIS | pmid:2841953 |
| Garg ML et al. | Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. | 1988 | Biochim. Biophys. Acta | pmid:2901857 |
| Croset M et al. | Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. | 1988 | Biochem. Pharmacol. | pmid:2965590 |
| Ansari KA and Shoeman D | Rapid separation of free fatty acids from neutral lipids in brain extracts. | 1988 | J. Chromatogr. | pmid:2969915 |
| Hruby K | [Is retinitis pigmentosa absolutely incurable?]. | 1988 | Klin Monbl Augenheilkd | pmid:2969995 |
| Tesoriere L et al. | Modulation by docosahexaenoic acid of the epinephrine-stimulated adenylate cyclase activity of the bovine retina. | 1988 | J. Neurochem. | pmid:2970525 |
| Shingu T et al. | Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). | 1988 | Adv Alcohol Subst Abuse | pmid:2975919 |
| Louie K et al. | Docosahexaenoate-containing molecular species of glycerophospholipids from frog retinal rod outer segments show different rates of biosynthesis and turnover. | 1988 | Biochemistry | pmid:2976602 |
| Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
| Takahashi R et al. | Plasma, platelet, and aorta fatty acids composition in response to dietary n-6 and n-3 fats supplementation in a rat model of non-insulin-dependent diabetes. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:2976815 |
| Karanian JW et al. | Smooth muscle effects of hydroxylated docosahexaenoates produced from human platelet. | 1988 | Biomed. Biochim. Acta | pmid:2977725 |
| Weissmann G et al. | Stimulus-response coupling in marine sponge cell aggregation: lipid metabolism and the function of exogenously added arachidonic and docosahexaenoic acids. | 1988 | Biochim. Biophys. Acta | pmid:2968121 |
| Lokesh BR et al. | Differential effects of docosahexaenoic acid and eicosapentaenoic acid on suppression of lipoxygenase pathway in peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:2825816 |
| Covens AL et al. | The effect of dietary supplementation with fish oil fatty acids on surgically induced endometriosis in the rabbit. | 1988 | Fertil. Steril. | pmid:2832216 |
| Ackman RG | Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. | 1988 | Atherosclerosis | pmid:2833284 |
| Ferretti A et al. | Occurrence of prostaglandin E3 in human urine as a result of marine oil ingestion: gas chromatographic-mass spectrometric evidence. | 1988 | Biochim. Biophys. Acta | pmid:3162687 |
| Maxepa--Eskimos, fish oils and ischaemic heart disease. | 1988 | Drug Ther Bull | pmid:3053081 | |
| Schmidt EB et al. | The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris. | 1988 | Artery | pmid:3178506 |
| Zucker ML et al. | Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. | 1988 | Atherosclerosis | pmid:3178928 |
| Miller JP et al. | Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study. | 1988 | Clin. Chim. Acta | pmid:3071435 |
| Croset M et al. | Different metabolic behavior of long-chain n-3 polyunsaturated fatty acids in human platelets. | 1988 | Biochim. Biophys. Acta | pmid:2839237 |
| Hörcher U | [Omega-3-fatty acids from fish oil for the prevention of myocardial infarct]. | 1988 | Pharm Unserer Zeit | pmid:2840674 |
| Ishiguro J et al. | [Effects of ethyl eicosapentaenoate (EPA-E) and its metabolite on the drug and fatty acid metabolizing enzyme systems in rat liver]. | 1988 | Yakugaku Zasshi | pmid:2841446 |
| Cardiovascular effects of n-3 fatty acids. | 1988 | N. Engl. J. Med. | pmid:2841599 | |
| Hatmi M et al. | Interference of eicosapentaenoic and docosahexaenoic acids with arachidonate-and U46619-induced platelet activation and desensitization. | 1988 | Biochem. Pharmacol. | pmid:2827688 |
| Whittle JC | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. | 1988 | Am. J. Med. | pmid:3376983 |
| Gibney MJ and Bolton-Smith C | The effect of a dietary supplement of n-3 polyunsaturated fat on platelet lipid composition, platelet function and platelet plasma membrane fluidity in healthy volunteers. | 1988 | Br. J. Nutr. | pmid:3408705 |
| Cahill PD et al. | Inhibition of vein graft intimal thickening by eicosapentanoic acid: reduced thromboxane production without change in lipoprotein levels or low-density lipoprotein receptor density. | 1988 | J. Vasc. Surg. | pmid:3336117 |
| Vandongen R et al. | Hypercholesterolaemic effect of fish oil in insulin-dependent diabetic patients. | 1988 | Med. J. Aust. | pmid:3340028 |
| Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Demke DM et al. | Effects of a fish oil concentrate in patients with hypercholesterolemia. | 1988 | Atherosclerosis | pmid:3355619 |