| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Karmali RA et al. | The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor. | 1987 Nov-Dec | Anticancer Res. | pmid:2831791 |
| Codde JP et al. | The effect of dietary fish oil and salt on blood pressure and eicosanoid metabolism of spontaneously hypertensive rats. | 1987 | J. Hypertens. | pmid:3611764 |
| Koletzko B | Omega-3 fatty acid requirement. | 1987 | Am. J. Clin. Nutr. | pmid:3039827 |
| Liu CC et al. | Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. | 1987 | Pediatr. Res. | pmid:2821474 |
| Mitchell EA et al. | Clinical characteristics and serum essential fatty acid levels in hyperactive children. | 1987 | Clin Pediatr (Phila) | pmid:2439249 |
| Philbrick DJ et al. | Ingestion of fish oil or a derived n-3 fatty acid concentrate containing eicosapentaenoic acid (EPA) affects fatty acid compositions of individual phospholipids of rat brain, sciatic nerve and retina. | 1987 | J. Nutr. | pmid:2822876 |
| Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
| Bjørneboe A et al. | Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. | 1987 | Br. J. Dermatol. | pmid:2823859 |
| Virkkunen ME et al. | Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. | 1987 | Biol. Psychiatry | pmid:2958095 |
| Takayama H et al. | Preferential incorporation of eicosanoid precursor fatty acids into human umbilical vein endothelial cell phospholipids. | 1987 | Biochim. Biophys. Acta | pmid:2825796 |
| Licensed fish-oil concentrate versus cod-liver oil. | 1987 | Lancet | pmid:2887752 | |
| Jones RG and Henderson MJ | Fish oils as medicines. | 1987 | Lancet | pmid:2887931 |
| Scott BL et al. | Docosahexaenoate metabolism and fatty-acid composition in developing retinas of normal and rd mutant mice. | 1987 | Exp. Eye Res. | pmid:2951268 |
| Anderson RE et al. | Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa. | 1987 | Exp. Eye Res. | pmid:2951269 |
| Hadjiagapiou C and Spector AA | Docosahexaenoic acid metabolism and effect on prostacyclin production in endothelial cells. | 1987 | Arch. Biochem. Biophys. | pmid:2949698 |
| Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
| Ojima A et al. | Selective transacylation of 1-O-alkylglycerophosphoethanolamine by docosahexaenoate and arachidonate in rat brain microsomes. | 1987 | J. Neurochem. | pmid:2951496 |
| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Infante JP | Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport. | 1987 | Mol. Cell. Biochem. | pmid:2955214 |
| Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
| Codde JP et al. | Effects of fish oil "Max EPA" on blood pressures and prostanoid metabolism of spontaneously hypertensive rats during salt loading. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960180 |
| Kobayashi S et al. | Changes of hemorrheological properties by highly purified DHA in normal subjects. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960200 |
| Organisciak DT et al. | Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. | 1987 | Prog. Clin. Biol. Res. | pmid:2960984 |
| Rotstein NP and Aveldaño MI | Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)) docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958089 |
| Rotstein NP and Aveldaño MI | Labeling of phosphatidylcholines of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)), docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958090 |
| Frank H et al. | Fatty acids in liver microsomal lipids of rats exposed to hypoxia, tetrachloromethane, or both. | 1987 | Biochim. Biophys. Acta | pmid:2959325 |
| del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
| Urakaze M et al. | Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits. | 1987 | Am. J. Clin. Nutr. | pmid:2825504 |
| von Schacky C | Prophylaxis of atherosclerosis with marine omega-3 fatty acids. A comprehensive strategy. | 1987 | Ann. Intern. Med. | pmid:2825573 |
| Zijlstra JG et al. | Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin-sensitive and -resistant small-cell lung cancer cell lines, and on cytotoxicity in the tumor cell lines. | 1987 | Int. J. Cancer | pmid:2826341 |
| Lokesh BR and Kinsella JE | Modulation of prostaglandin synthesis in mouse peritoneal macrophages by enrichment of lipids with either eicosapentaenoic or docosahexaenoic acids in vitro. | 1987 | Immunobiology | pmid:2828226 |
| Mori TA et al. | New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation. | 1987 | Lipids | pmid:2828811 |
| Fischer S et al. | Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. | 1987 | Prostaglandins | pmid:2829279 |
| van Acker BA et al. | The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients. | 1987 | Nephrol. Dial. Transplant. | pmid:2831474 |
| Fish oil for the heart. | 1987 | Med Lett Drugs Ther | pmid:3025574 | |
| Yoshino S and Ellis EF | Effect of a fish-oil-supplemented diet on inflammation and immunological processes in rats. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:2820885 |
| Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
| Chamberlain JG and Belton C | Effects of long term consumption of fish oil (Maxepa) on serum lipids and arterial ultrastructure in Japanese quail (Coturnix coturnix japonica). | 1987 | Atherosclerosis | pmid:3689486 |
| Maurice PD et al. | The effects of dietary supplementation with fish oil in patients with psoriasis. | 1987 | Br. J. Dermatol. | pmid:3689678 |
| Thiery J and Seidel D | Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3827970 |
| Sanders TA | Re: Fish oil feeding results in enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3675708 |
| Cendrowski W | Multiple sclerosis and MaxEPA. | 1986 | Br J Clin Pract | pmid:3542002 |
| Applegate KR and Glomset JA | Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. | 1986 | J. Lipid Res. | pmid:2943846 |
| Weiner MA | Cholesterol in foods rich in omega-3 fatty acids. | 1986 | N. Engl. J. Med. | pmid:2943996 |
| Haines AP et al. | Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. | 1986 | Thromb. Res. | pmid:3020732 |
| Croset M and Lagarde M | In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. | 1986 | Thromb. Haemost. | pmid:3022414 |
| Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
| Masuzawa Y et al. | Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells. | 1986 | Biochim. Biophys. Acta | pmid:2936397 |
| Hsia JC et al. | Determination of the distribution of fatty acids and diethylstilbestrol between serum albumin and alpha-fetoprotein by concanavalin A affinity chromatography. | 1986 | Biochim. Biophys. Acta | pmid:2417630 |
| Huterer S and Wherrett JR | Incorporation of polyunsaturated fatty acids into bis(monoacylglycero)phosphate and other lipids of macrophages and of fibroblasts from control and Niemann-Pick patients. | 1986 | Biochim. Biophys. Acta | pmid:2937457 |
| German JB et al. | Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids. | 1986 | Biochim. Biophys. Acta | pmid:3000452 |
| Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
| Hagve TA and Christophersen BO | Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells. | 1986 | Biochim. Biophys. Acta | pmid:2935195 |
| German JB and Kinsella JE | Hydroperoxide metabolism in trout gill tissue: effect of glutathione on lipoxygenase products generated from arachidonic acid and docosahexaenoic acid. | 1986 | Biochim. Biophys. Acta | pmid:2946321 |
| Bazan NG et al. | Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2948509 |
| Carlson SE et al. | Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | 1986 | Am. J. Clin. Nutr. | pmid:2947455 |
| Meduri R et al. | [Effects of zinc and docosahexenoic acid on the corneal and cerebral lesions of rabbits infected with herpesvirus]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947654 |
| Scorolli L et al. | [Changes induced by zinc and docosahexenoic acid in acute NaIO3 poisoning]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947655 |
| Hong CY et al. | Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm. | 1986 | Int. J. Androl. | pmid:2947864 |
| Ziboh VA et al. | Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Modulation of clinical course of psoriatic subjects. | 1986 | Arch Dermatol | pmid:3022655 |
| Organisciak DT et al. | Rod outer segment lipids in vitamin A-adequate and -deficient rats. | 1986 | Exp. Eye Res. | pmid:2937648 |
| Tou JS | Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. | 1986 | Lipids | pmid:2941637 |
| Yergey JA et al. | High-performance liquid chromatography/thermospray mass spectrometry of eicosanoids and novel oxygenated metabolites of docosahexaenoic acid. | 1986 | Anal. Chem. | pmid:2942056 |
| Guisto NM et al. | Active labeling of phosphatidylcholines by [1-14C]docosahexaenoate in isolated photoreceptor membranes. | 1986 | Biochim. Biophys. Acta | pmid:2942188 |
| Lee TH et al. | Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. | 1986 | J. Immunol. | pmid:3005414 |
| Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
| Norris PG et al. | Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. | 1986 | Br Med J (Clin Res Ed) | pmid:3089408 |
| Rylance PB et al. | Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients. | 1986 | Nephron | pmid:3724927 |
| Sullivan DR et al. | Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil. | 1986 | Atherosclerosis | pmid:3753548 |
| Claeys M et al. | Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. | 1986 | Prostaglandins | pmid:2951768 |
| Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
| Cendrowski W | [MaxEpa in multiple sclerosis]. | 1985 | Wiad. Lek. | pmid:3913158 |
| Simons LA et al. | On the effects of dietary n-3 fatty acids (Maxepa) on plasma lipids and lipoproteins in patients with hyperlipidaemia. | 1985 | Atherosclerosis | pmid:3888229 |
| Skorepa J et al. | [The effect of fish oils on plasma lipid levels in hyperlipidemics]. | 1985 | Cas. Lek. Cesk. | pmid:3896497 |
| Cartwright IJ et al. | The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. | 1985 | Atherosclerosis | pmid:4015748 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Lee TH et al. | Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. | 1985 | N. Engl. J. Med. | pmid:2985986 |
| Singer P et al. | Influence on serum lipids, lipoproteins and blood pressure of mackerel and herring diet in patients with type IV and V hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:2992534 |
| Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
| von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
| Reddy TS et al. | Change in content, incorporation and lipoxygenation of docosahexaenoic acid in retina and retinal pigment epithelium in canine ceroid lipofuscinosis. | 1985 | Neurosci. Lett. | pmid:2931631 |
| Cunnane SC et al. | Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid. | 1985 | J. Nutr. | pmid:2932544 |
| Reynolds JW | Enteral and parenteral nutrition of low birth weight infants. | 1985 | Bol Asoc Med P R | pmid:2933046 |
| Mabe H et al. | [Effect of calcium entry blocker, nimodipine, on the cerebral function and metabolic recovery following experimental cerebral ischemia]. | 1985 | No To Shinkei | pmid:2934079 |
| Dietary fish oil increases omega-3 long-chain polyunsaturated fatty acids in human milk. | 1985 | Nutr. Rev. | pmid:2934649 | |
| Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
| Parks JE and Hammerstedt RH | Development changes occurring in the lipids of ram epididymal spermatozoa plasma membrane. | 1985 | Biol. Reprod. | pmid:3158356 |
| Singer P et al. | Blood pressure- and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension. | 1985 | Atherosclerosis | pmid:3000395 |
| von Schacky C and Weber PC | Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. | 1985 | J. Clin. Invest. | pmid:3001149 |
| Onuma Y et al. | Selective incorporation of docosahexaenoic acid in rat brain. | 1984 | Biochim. Biophys. Acta | pmid:6231055 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| Sanders TA | Dietary polyunsaturated fatty acids and health. | 1984 | Br J Clin Pract Suppl | pmid:6091718 |
| Bazan HE et al. | De novo biosynthesis of docosahexaenoyl-phosphatidic acid in bovine retinal microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6091768 |
| Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
| Fogerty AC et al. | Liver fatty acids and the sudden infant death syndrome. | 1984 | Am. J. Clin. Nutr. | pmid:6230001 |
| Fischer S et al. | Uptake, release and metabolism of docosahexaenoic acid (DHA, c22:6 omega 3) in human platelets and neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329189 |
| Lee TH et al. | Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. | 1984 | J. Clin. Invest. | pmid:6096400 |