DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Yi SH et al. A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22000478
Rahman M et al. Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. 2011 PLoS ONE pmid:22140508
Johnson B Consciousness reinstated using the certainty principle--a better mental health strategy. 2011 Nutr Health pmid:22141192
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Liu SJ et al. Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. 2011 J. Dairy Sci. pmid:21605768
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Serini S et al. Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved. 2011 Curr. Med. Chem. pmid:21824086
Fagali N and Catalá A Melatonin and structural analogues do not possess antioxidant properties on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. 2011 Chem. Phys. Lipids pmid:21827740
Giltay EJ et al. Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. 2011 Am. J. Clin. Nutr. pmid:22030221
Klebanoff MA et al. Fish consumption, erythrocyte fatty acids, and preterm birth. 2011 Obstet Gynecol pmid:21508745
Pomponi MF et al. Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? 2011 Ageing Res. Rev. pmid:20920611
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van der Pols JC et al. Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21217086
Murphy RA et al. Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. 2011 Cancer pmid:21360698
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Serini S et al. Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. 2011 J. Nutr. Biochem. pmid:21185708
Riedel M et al. Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. 2011 J. Mol. Neurosci. pmid:20725866
Leon MM et al. [Resolution of inflammation--pharmacological aspects]. 2011 Apr-Jun Rev Med Chir Soc Med Nat Iasi pmid:21870743
Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
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Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
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Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
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Gladyshev MI et al. Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. 2011 Mar-Apr Dokl. Biochem. Biophys. pmid:21590375
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
Kilari A et al. Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. 2011 May-Jun Am. J. Hum. Biol. pmid:21484911
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Maki KC et al. Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. 2011 Nov-Dec J Clin Lipidol pmid:22108152
Siddiqui RA et al. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. 2011 Nov-Dec Biofactors pmid:22038684
Opperman M et al. Analysis of omega-3 fatty acid content of South African fish oil supplements. 2011 Nov-Dec Cardiovasc J Afr pmid:22159321
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Maki KC et al. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21775113
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Fabelo N et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. 2011 Sep-Oct Mol. Med. pmid:21717034
Shilina NM et al. [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. 2011 Sep-Oct Biomed Khim pmid:22629608
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Ortiz-Alvarado O et al. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. 2012 Urology pmid:22000931
Ling PR et al. Arachidonic acid and docosahexaenoic acid supplemented to an essential fatty acid-deficient diet alters the response to endotoxin in rats. 2012 Metab. Clin. Exp. pmid:21944266
Kim HW et al. Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. 2012 Psychopharmacology (Berl.) pmid:22414961
Sinn N et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. 2012 Br. J. Nutr. pmid:21929835
Drover JR et al. A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. 2012 Early Hum. Dev. pmid:22835597
Chew EY et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). 2012 Ophthalmology pmid:22840421
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Isobe Y et al. Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. 2012 J. Biol. Chem. pmid:22275352
Mozaffarian D and Wu JH (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? 2012 J. Nutr. pmid:22279134
Macášek J et al. Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. 2012 Nutr Cancer pmid:23061902
Maki KC and Rains TM Stearidonic acid raises red blood cell membrane eicosapentaenoic acid. 2012 J. Nutr. pmid:22279138
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Shi T et al. Identification of a novel C22-∆4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. 2012 Biotechnol. Lett. pmid:22941368
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Cunningham E Are krill oil supplements a better source of n-3 fatty acids than fish oil supplements? 2012 J Acad Nutr Diet pmid:22459227
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Pottala JV et al. Red blood cell fatty acids are associated with depression in a case-control study of adolescents. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464051
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da Silva Acosta D et al. Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. 2012 Fish Physiol. Biochem. pmid:22451341
Du Q et al. Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. 2012 J. Nutr. Biochem. pmid:22445803
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Bazan NG et al. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. 2012 Exp. Neurol. pmid:22542947
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Labrousse VF et al. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. 2012 PLoS ONE pmid:22662127
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