| MeSH term | MeSH ID | Detail |
|---|---|---|
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Diabetes Complications | D048909 | 4 associated lipids |
| Keratitis, Herpetic | D016849 | 5 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Macular Degeneration | D008268 | 5 associated lipids |
| Peroxisomal Disorders | D018901 | 5 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Vibrio Infections | D014735 | 5 associated lipids |
| Abortion, Habitual | D000026 | 5 associated lipids |
| Intermittent Claudication | D007383 | 6 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morris T et al. | New perspectives on aspirin and the endogenous control of acute inflammatory resolution. | 2006 | ScientificWorldJournal | pmid:16951898 |
| de Urquiza AM et al. | Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. | 2000 | Science | pmid:11118147 |
| Fernández-González R et al. | Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. | 2014 | Sci. Total Environ. | pmid:24095964 |
| Glomset JA | Role of docosahexaenoic acid in neuronal plasma membranes. | 2006 | Sci. STKE | pmid:16467193 |
| Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
| Li Q et al. | Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. | 2006 | Sci. China, C, Life Sci. | pmid:16544577 |
| Sapieha P et al. | 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. | 2011 | Sci Transl Med | pmid:21307302 |
| Chen CT et al. | Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. | 2015 | Sci Rep | pmid:26511533 |
| Dalli J et al. | Novel n-3 immunoresolvents: structures and actions. | 2013 | Sci Rep | pmid:23736886 |
| Sharma S et al. | High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. | 2012 | Sci Rep | pmid:22666534 |
| Wang CS et al. | ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. | 2016 | Sci Rep | pmid:27064029 |
| Schmitt Y and Schneider H | [Effect of the administration of highly-unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology of patients under chronic hemodialysis treatment]. | 1991 | Schweiz Med Wochenschr | pmid:1836897 |
| McNamara RK et al. | Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. | 2007 | Schizophr. Res. | pmid:17236749 |
| Kale A et al. | Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. | 2008 | Schizophr. Res. | pmid:17997280 |
| Peet M et al. | Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. | 2001 | Schizophr. Res. | pmid:11356585 |
| Ward PE et al. | Niacin skin flush in schizophrenia: a preliminary report. | 1998 | Schizophr. Res. | pmid:9516668 |
| McNamara RK | Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? | 2011 | Schizophr. Res. | pmid:21276713 |
| Harper KN et al. | Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. | 2011 | Schizophr. Res. | pmid:21324652 |
| McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
| Medema S et al. | Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. | 2016 | Schizophr Bull | pmid:26385764 |