DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Pain D010146 64 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Raederstorff D et al. Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. 1996 Int. Arch. Allergy Immunol. pmid:8917124
Hamazaki T et al. Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. 1996 J. Nutr. pmid:8914949
Marignani PA and Sebaldt RJ The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. 1996 J. Nutr. pmid:8914943
Woods J et al. Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. 1996 Pediatr. Res. pmid:8910933
Crosby AJ et al. Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. 1996 Biochim. Biophys. Acta pmid:8908152
Retterstøl K et al. The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. 1996 Biochim. Biophys. Acta pmid:8908151
Chambon M et al. Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. 1996 Transplant. Proc. pmid:8908096
Yamada K et al. Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. 1996 J. Nutr. Sci. Vitaminol. pmid:8906631
Vreugdenhil M et al. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8901621
Farkas K et al. Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. 1996 Lipids pmid:8900461
Ohno T et al. Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. 1996 Jpn. J. Physiol. pmid:8899494
Farkas K et al. Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. 1996 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:8896327
Luukkainen P et al. Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. 1996 J. Pediatr. Gastroenterol. Nutr. pmid:8890071
Abbate R et al. n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888356
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Horrobin DF Schizophrenia as a membrane lipid disorder which is expressed throughout the body. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888116
Dahlan W et al. Fish meal lecithin as alternative precursor of docosahexaenoate and choline. 1996 Biomed. Environ. Sci. pmid:8886341
Lambert MS et al. Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. 1996 Br. J. Nutr. pmid:8881715
Alessandri JM et al. Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. 1996 Reprod. Nutr. Dev. pmid:8881596
Hughes DA and Pinder AC Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. 1996 Biochem. Soc. Trans. pmid:8878933
Schjøtt J et al. Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. 1996 Pharmacol. Toxicol. pmid:8878248
Berkenboom G et al. Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. 1996 Cardiovasc Drugs Ther pmid:8877082
Oski FA Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. 1996 Nutrition pmid:8875527
Stillwell W et al. Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. 1996 Biochemistry pmid:8873602
Liu W et al. Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. 1995 Kobe J Med Sci pmid:8869009
Hamano H et al. Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. 1996 J. Neurophysiol. pmid:8867135
Saito M et al. An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. 1996 J. Nutr. Sci. Vitaminol. pmid:8866256
Baskaya MK et al. Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860103
Reithmann C et al. Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. 1996 Naunyn Schmiedebergs Arch. Pharmacol. pmid:8857587
Karmali RA Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. 1996 Nutrition pmid:8850210
Organisciak DT et al. Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. 1996 Invest. Ophthalmol. Vis. Sci. pmid:8843911
Leaf A et al. Long chain polyunsaturated fatty acids and visual function in preterm infants. 1996 Early Hum. Dev. pmid:8842638
Brossard N et al. Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. 1996 Am. J. Clin. Nutr. pmid:8839503
Frøyland L et al. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. 1996 Lipids pmid:8835405
Okada M et al. The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. 1996 Neuroscience pmid:8834389
Khair-el-Din TA et al. Inhibition of macrophage nitric-oxide production and Ia-expression by docosahexaenoic acid, a constituent of fetal and neonatal serum. 1996 Am. J. Reprod. Immunol. pmid:8831896
Ku K et al. The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. 1996 Transplantation pmid:8824469
Polette A et al. N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. 1996 Thromb. Haemost. pmid:8822591
Bayorh MA et al. Effects of MaxEPA on salt-induced hypertension: relationship to [3H]nitrobenzylthioinosine binding sites. 1996 Clin. Exp. Hypertens. pmid:8822232
Pöschl JM et al. Dietary docosahexaenoic acid improves red blood cell deformability in rats. 1996 Thromb. Res. pmid:8822144
Huang MC and Craig-Schmidt MC Arachidonate and docosahexaenoate added to infant formula influence fatty acid composition and subsequent eicosanoid production in neonatal pigs. 1996 J. Nutr. pmid:8814208
Fernández-Bañares F et al. Changes of the mucosal n3 and n6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence. 1996 Gut pmid:8801207
Xu LZ et al. Ligand specificity of brain lipid-binding protein. 1996 J. Biol. Chem. pmid:8798739
Carnielli VP et al. The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. 1996 Pediatr. Res. pmid:8798265
Simonelli F et al. Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. 1996 Ophthalmic Res. pmid:8792359
Mitjavila MT et al. Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. 1996 Lipids pmid:8784749
Dembitsky VM and Rezanka T Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. 1996 Lipids pmid:8784746
Innis SM et al. Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. 1996 Lipids pmid:8784742
Willumsen N et al. Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. 1996 Lipids pmid:8784738
Minami M and Noguchi M Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. 1996 Sep-Oct Oncology pmid:8784475
Palozza P et al. n-3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation. 1996 Am. J. Clin. Nutr. pmid:8780337
Lecomte M et al. Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. 1996 J. Neurochem. pmid:8780049
Rotstein NP et al. Docosahexaenoic acid is required for the survival of rat retinal photoreceptors in vitro. 1996 J. Neurochem. pmid:8780010
Maccoll AJ et al. Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils. 1996 Br. J. Nutr. pmid:8774223
Weisinger HS et al. Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. 1996 Ann. Nutr. Metab. pmid:8773733
Boswell K et al. Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. 1996 Food Chem. Toxicol. pmid:8761351
Yamada Y et al. Effect of eicosapentaenoic acid and docosahexaenoic acid on diabetic osteopenia. 1995 Diabetes Res. Clin. Pract. pmid:8745204
Degrace P et al. Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. 1996 Lipids pmid:8743053
Sasaki H et al. [Immunosuppressive effect of intravenously injected docosahexaenoic acid on single lung allotransplantation in the rat]. 1996 Nihon Kyobu Geka Gakkai Zasshi pmid:8741552
McLennan P et al. The cardiovascular protective role of docosahexaenoic acid. 1996 Eur. J. Pharmacol. pmid:8741170
Boehm G et al. Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids. 1996 Eur. J. Pediatr. pmid:8741041
Cerolini S et al. Preferential mobilisation of docosahexaenoic acid from adipose tissue triacylglycerol of the chick embryo. 1996 Biochem. Soc. Trans. pmid:8736823
Green P and Yavin E Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. 1996 Lipids pmid:8729125
Connor WE et al. Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. 1996 Lipids pmid:8729116
Gibson RA et al. Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. 1996 Lipids pmid:8729115
Martinez M Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. 1996 Lipids pmid:8729110
Croset M et al. In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. 1996 Lipids pmid:8729104
De Caterina R and Libby P Control of endothelial leukocyte adhesion molecules by fatty acids. 1996 Lipids pmid:8729095
Carlson SE et al. Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. 1996 Pediatr. Res. pmid:8726246
Hammes HP et al. Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids. 1996 Diabetologia pmid:8721768
Chen Y et al. Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. 1996 J. Biol. Chem. pmid:8702792
Lim BO et al. Effects of n-3 polyunsaturated fatty acids and lectins on immunoglobulin production by spleen lymphocytes of Sprague-Dawley rats. 1996 Biosci. Biotechnol. Biochem. pmid:8695902
Innis SM and Hansen JW Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. 1996 Am. J. Clin. Nutr. pmid:8694015
Yamane M et al. Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma. 1996 J Chromatogr A pmid:8680600
Tamura M and Suzuki H Effect of docosahexaenoic acid and sardine oil diets on the ultrastructure of hepatocytes in adult mice. 1995 J. Nutr. Sci. Vitaminol. pmid:8676220
Lagarde M [Biosynthesis and functions of eicosanoids. Recent data]. 1995 C. R. Seances Soc. Biol. Fil. pmid:8673630
Rotstein NP et al. Active synthesis of C24:5, n-3 fatty acid in retina. 1996 Biochem. J. pmid:8670163
Innis SM et al. Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age. 1996 Am. J. Clin. Nutr. pmid:8669412
Marzo I et al. Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. 1996 Biochim. Biophys. Acta pmid:8664338
Luthria DL et al. Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid. 1996 J. Biol. Chem. pmid:8663162
Moore SA et al. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. 1995 J. Lipid Res. pmid:8656081
Beijers RJ and Schaafsma A Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation. 1996 Early Hum. Dev. pmid:8654314
Balestrieri GP et al. Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. 1996 Recenti Prog Med pmid:8650428
Jørgensen MH et al. Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. 1996 Lipids pmid:8649242
Werkman SH and Carlson SE A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. 1996 Lipids pmid:8649241
Carlson SE and Werkman SH A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. 1996 Lipids pmid:8649239
Weisinger HS et al. The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. 1996 Lipids pmid:8649236
Makrides M et al. Is dietary docosahexaenoic acid essential for term infants? 1996 Lipids pmid:8649228
Prisco D et al. Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. 1996 Am. J. Clin. Nutr. pmid:8644688
Khair-El-Din T et al. Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. 1996 J. Exp. Med. pmid:8642266
Engler MB and Engler MM Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. 1996 Gerontology pmid:8641598
Serhiienko OO [The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)]. 1995 May-Jun Lik. Sprava pmid:8630815
Pageaux JF et al. Biogenesis and metabolic fate of docosahexaenoic and arachidonic acids in rat uterine stromal cells in culture. 1996 Arch. Biochem. Biophys. pmid:8615684
Carlson SE et al. Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. 1996 Am. J. Clin. Nutr. pmid:8615350
Shashoua VE and Hesse GW N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. 1996 Life Sci. pmid:8614292
Hamazaki T et al. The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. 1996 J. Clin. Invest. pmid:8613538
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. 1996 Scand. J. Immunol. pmid:8602457
Hughes DA et al. (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. 1996 J. Nutr. pmid:8598544
Christensen JH et al. Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. 1996 BMJ pmid:8597736