DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Pain D010146 64 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Shikano M et al. Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl- and alkenylacylglycerophosphoethanolamine. 1994 Biochim. Biophys. Acta pmid:8180247
Bouziane M et al. Dietary protein deficiency affects n-3 and n-6 polyunsaturated fatty acids hepatic storage and very low density lipoprotein transport in rats on different diets. 1994 Lipids pmid:8177019
Andersson L et al. Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. Effect of bile salts. 1994 Scand. J. Gastroenterol. pmid:8171289
Ter-Karapetian VA [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. 1994 Voen Med Zh pmid:8165800
Demoz A et al. Modulation of plasma and hepatic oxidative status and changes in plasma lipid profile by n-3 (EPA and DHA), n-6 (corn oil) and a 3-thia fatty acid in rats. 1994 Biochim. Biophys. Acta pmid:8161562
Anderson RE et al. Plasma lipid changes in PRCD-affected and normal miniature poodles given oral supplements of linseed oil. Indications for the involvement of n-3 fatty acids in inherited retinal degenerations. 1994 Exp. Eye Res. pmid:8157107
Rodriguez de Turco EB et al. Docosahexaenoic acid is taken up by the inner segment of frog photoreceptors leading to an active synthesis of docosahexaenoyl-inositol lipids: similarities in metabolism in vivo and in vitro. 1994 Curr. Eye Res. pmid:8156822
Zhu BQ et al. Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? 1994 Am. Heart J. pmid:8154411
Leung FW Prostaglandins mediate fish oil protection against ethanol-induced gastric mucosal injury in rats. 1994 Dig. Dis. Sci. pmid:8149856
Shiina T et al. Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. 1993 Atherosclerosis pmid:8141854
Bénistant C et al. Platelet inhibitory functions of aortic endothelial cells. Effects of eicosapentaenoic and docosahexaenoic acids. 1993 Atherosclerosis pmid:8141848
Schjøtt J et al. Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. 1993 Scand. J. Clin. Lab. Invest. pmid:8140399
Hardy SJ et al. In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids. 1994 J. Neurochem. pmid:8133282
Piatti G et al. Delaying effects of dietary eicosapentaenoic-docosahexaenoic acids on development of "fatty streaks" in hypercholesterolaemic rabbits. A morphological study by scanning electron microscopy. 1993 Drugs Exp Clin Res pmid:8131713
Honoré E et al. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8127910
Henderson WR et al. Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects. 1994 J. Pediatr. pmid:8120709
Somers SD and Erickson KL Alteration of tumor necrosis factor-alpha production by macrophages from mice fed diets high in eicosapentaenoic and docosahexaenoic fatty acids. 1994 Cell. Immunol. pmid:8118867
Wakabayashi S et al. In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats. 1994 J. Cereb. Blood Flow Metab. pmid:8113326
Alvarez RA et al. Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. 1994 Invest. Ophthalmol. Vis. Sci. pmid:8112987
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Spady DK Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. 1993 J. Lipid Res. pmid:8105015
Bourre JM et al. Dietary alpha-linolenic acid at 1.3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. 1993 J. Nutr. pmid:8100576
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Hanai T et al. Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. 1993 J. Surg. Res. pmid:8094103
Fonlupt P et al. Incorporation of arachidonic and docosahexaenoic acids into phospholipids of rat brain membranes. 1994 Neurosci. Lett. pmid:8084475
Alberghina M et al. Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat. 1994 Neurosci. Lett. pmid:8084474
Pyzh MV et al. [Food supplement containing ω-3 polyunsaturated fatty acids prevents experimental thrombotic occlusion of coronary arteries in dogs]. 1993 Kardiologiia pmid:8084128
Jump DB et al. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. 1994 J. Lipid Res. pmid:8077846
McVeigh GE et al. Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. 1994 Arterioscler. Thromb. pmid:8068603
Sukenik A et al. Dietary lipids from marine unicellular algae enhance the amount of liver and blood omega-3 fatty acids in rats. 1994 Ann. Nutr. Metab. pmid:8067689
Karanian JW et al. Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8066103
Takahashi M et al. Effect of docosahexaenoic acid on azoxymethane-induced colon carcinogenesis in rats. 1994 Cancer Lett. pmid:8062213
Reddy S et al. The influence of maternal vegetarian diet on essential fatty acid status of the newborn. 1994 Eur J Clin Nutr pmid:8055852
Brand MD et al. Liposomes from mammalian liver mitochondria are more polyunsaturated and leakier to protons than those from reptiles. 1994 Comp. Biochem. Physiol. Biochem. Mol. Biol. pmid:8055185
North JA et al. Cell fatty acid composition affects free radical formation during lipid peroxidation. 1994 Am. J. Physiol. pmid:8048478
Felouati BE et al. Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine. 1994 Biochem. J. pmid:8042978
Wang H et al. The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B. 1994 J. Biol. Chem. pmid:8034600
Haglund O et al. Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects. 1994 Am. J. Cardiol. pmid:8023790
Sacks FM et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. 1994 J. Hypertens. pmid:8021472
Shahar E et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. 1994 N. Engl. J. Med. pmid:8015569
Carlson SE et al. Long-chain fatty acids and early visual and cognitive development of preterm infants. 1994 Eur J Clin Nutr pmid:7995262
Belluzzi A et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. 1994 Dig. Dis. Sci. pmid:7995183
Bright JM et al. The effects of n-3 fatty acid supplementation on bleeding time, plasma fatty acid composition, and in vitro platelet aggregation in cats. 1994 Jul-Aug J. Vet. Intern. Med. pmid:7983618
Brossard N et al. Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study the in vivo compartmental metabolism of docosahexaenoic acid. 1994 Anal. Biochem. pmid:7978245
Thies F et al. Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. 1994 Am. J. Physiol. pmid:7977854
Imre SG et al. Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. 1994 Stroke pmid:7974583
Yano Y et al. Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. 1994 Lipids pmid:7968276
Hardy SC and Kleinman RE Fat and cholesterol in the diet of infants and young children: implications for growth, development, and long-term health. 1994 J. Pediatr. pmid:7965456
Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
Carlson SE Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials. 1994 J. Pediatr. pmid:7965451
Saito M and Nakatsugawa K Increased susceptibility of liver to lipid peroxidation after ingestion of a high fish oil diet. 1994 Int J Vitam Nutr Res pmid:7960494
Anti M et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. 1994 Gastroenterology pmid:7958682
Eritsland J et al. Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. 1994 Scand. J. Clin. Lab. Invest. pmid:7939369
Kang JX and Leaf A Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7937911
Karanian JW et al. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. 1994 J. Pharmacol. Exp. Ther. pmid:7932158
Ikeda I et al. alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. 1994 J. Nutr. pmid:7931698
Arm JP et al. Leukotrienes, fish-oil, and asthma. 1994 May-Jun Allergy Proc pmid:7926711
del Carmen Boyano-Adánez M et al. Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. 1994 Biochim. Biophys. Acta pmid:7918608
Tremoli E et al. n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes. 1994 Arterioscler. Thromb. pmid:7918310
Winters BL et al. Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. 1994 J. Nutr. pmid:7916377
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Anderson GJ and Connor WE Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. 1994 Am. J. Clin. Nutr. pmid:7911000
Green P and Yavin E Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. 1993 J. Lipid Res. pmid:7905509
Ghebremeskel K et al. Fatty acid composition of plasma and red cell phospholipids of preterm babies fed on breast milk and formulae. 1995 Eur. J. Pediatr. pmid:7895755
Karikó K et al. Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. 1995 FEBS Lett. pmid:7890029
Gibney MJ and Daly E The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. 1994 Eur J Clin Nutr pmid:7889895
Purasiri P et al. Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. 1994 Clin. Sci. pmid:7874864
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Martinez M Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. 1994 World Rev Nutr Diet pmid:7871835
von Houwelingen AC and Hornstra G Trans fatty acids in early human development. 1994 World Rev Nutr Diet pmid:7871822
Anderson RE et al. The accretion of docosahexaenoic acid in the retina. 1994 World Rev Nutr Diet pmid:7871813
Bazan NG et al. Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. 1994 World Rev Nutr Diet pmid:7871812
Chen LY et al. Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. 1994 Thromb. Res. pmid:7871491
Poling JS et al. Time- and voltage-dependent block of delayed rectifier potassium channels by docosahexaenoic acid. 1995 Mol. Pharmacol. pmid:7870048
Tessier C et al. Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation. 1995 Biochem. Biophys. Res. Commun. pmid:7864887
Al MD et al. The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. 1994 World Rev Nutr Diet pmid:7856218
Alexander-North LS et al. Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. 1994 J. Lipid Res. pmid:7852854
Lokesh BR and Kinsella JE Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846090
Vaidyanathan VV et al. Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. 1994 Neurosci. Lett. pmid:7845615
Yamashiro Y et al. Docosahexaenoic acid status of patients with extrahepatic biliary atresia. 1994 J. Pediatr. Surg. pmid:7844720
Terasawa F et al. Effects of dietary casein and soy-protein on metabolic conversion of eicosapentaenoic acid to docosahexaenoic acid in the liver of rat. 1994 J. Nutr. Sci. Vitaminol. pmid:7844642
Popp-Snijders C and Blonk MC Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long-term dietary intake of eicosapentaenoic and docosahexaenoic acid. 1995 Am. J. Clin. Nutr. pmid:7840075
Kurlandsky LE et al. The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. 1994 Pediatr. Pulmonol. pmid:7838619
Bazan NG and Rodriguez de Turco EB Review: pharmacological manipulation of docosahexaenoic-phospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. 1994 J Ocul Pharmacol pmid:7836869
Gazzah N et al. Decrease of brain phospholipid synthesis in free-moving n-3 fatty acid deficient rats. 1995 J. Neurochem. pmid:7830085
Delton I et al. Distribution and metabolism of arachidonic and docosahexaenoic acids in rat pineal cells. Effect of norepinephrine. 1995 Biochim. Biophys. Acta pmid:7827119
Christensen MS et al. Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. 1995 Am. J. Clin. Nutr. pmid:7825539
Das UN Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824535
Gazzah N et al. Evidence for brain docosahexaenoate recycling in the free-moving adult rat: implications for measurement of phospholipid synthesis. 1994 Neurosci. Lett. pmid:7824158
Petroni A et al. Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. 1994 Neurochem. Res. pmid:7824073
Khair-el-Din TA et al. Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro. 1995 J. Immunol. pmid:7822798
Roche H and Gibney MJ The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. 1994 Int J Vitam Nutr Res pmid:7814240
Kim HY et al. Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. 1994 Anal. Chem. pmid:7810900
Mallampalli RK et al. Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids. 1994 Am. J. Physiol. pmid:7810669
Kinoshita K et al. Inhibitory effects of purified eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of murine transplantable mammary tumor. 1994 May-Jun In Vivo pmid:7803721
Zerouga M et al. Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers. 1995 Biochim. Biophys. Acta pmid:7794965
Jenski LJ et al. Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine splenocytes. 1995 Biochim. Biophys. Acta pmid:7794954
Burdge GC and Postle AD Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. 1995 Biochim. Biophys. Acta pmid:7786898
Shimizu S et al. omega-Hydroxylation of docosahexaenoic acid or arachidonic acid in human colonic well differentiated adenocarcinoma homogenate. 1995 Biochim. Biophys. Acta pmid:7786890