DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Carcinoma D002277 18 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Intracranial Arteriosclerosis D002537 4 associated lipids
Brain Ischemia D002545 89 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Agren JJ et al. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430389
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Chen ZY and Istfan NW Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161587
Ott J et al. Lipids in critical care medicine. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21546231
Yoshino S and Ellis EF Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550967
Bégin ME et al. Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550969
Aoki N et al. Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2550971
Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Hashimoto M et al. Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16165346
von Schacky C Cardiovascular disease prevention and treatment. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19520557
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Bazan NG Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19520558
Hsieh AT and Brenna JT Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19524425
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
Burdge GC Metabolism of alpha-linolenic acid in humans. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16828546
Whelan J et al. Docosahexaenoic acid: measurements in food and dietary exposure. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19493663
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Makrides M Is there a dietary requirement for DHA in pregnancy? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500960
Dalton A et al. A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19201180
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
Lien EL Toxicology and safety of DHA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19501496
Chen CT et al. Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19237271
Nieminen LR et al. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16959481
Kris-Etherton PM et al. Dietary reference intakes for DHA and EPA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19525100
Sanders TA DHA status of vegetarians. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500961
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Le HD et al. The essentiality of arachidonic acid and docosahexaenoic acid. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540099
Kuratko CN and Salem N Biomarkers of DHA status. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545987
Holub BJ Docosahexaenoic acid (DHA) and cardiovascular disease risk factors. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545988
McNamara RK Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521863
Dyerberg J et al. Bioavailability of marine n-3 fatty acid formulations. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20638827
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Lagarde M et al. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22520055
Rapoport SI et al. Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20226642
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Bonham MP et al. Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study). 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18585023
Gramer G et al. Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27269713
Kim HY and Spector AA Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22959887
Rapoport SI et al. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18060754
Mukherjee PK et al. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18060755
Huang LL et al. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23474173
Kuipers RS et al. Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21903369
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Horrocks LA and Farooqui AA Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041028
Harris WS and Schmitt TL Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. 2014 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:24393427
Rapoport SI Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18973997
Tyburczy C et al. Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21885269
Ye S et al. Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20206488
Erdogan H et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253883
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
Childs CE et al. Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. 2010 Oct-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:20817424
Krabbendam L et al. Relationship between DHA status at birth and child problem behaviour at 7 years of age. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17074476
Qin X et al. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802938
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Ly LH et al. Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16221546
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Jolly CA et al. Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654402
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Hurst S et al. Dietary fatty acids and arthritis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20189789
Kim HY et al. Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207120
Minns LM et al. Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207123
Sarri KO et al. Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18258421
Levy BD Resolvins and protectins: natural pharmacophores for resolution biology. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20227865
Ren H et al. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16410047
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Parletta N et al. Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23756346
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Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
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Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
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Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
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Das UN Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824535
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van Goor SA et al. Maternal and fetal brain contents of docosahexaenoic acid (DHA) and arachidonic acid (AA) at various essential fatty acid (EFA), DHA and AA dietary intakes during pregnancy in mice. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18343099
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Matsumoto K et al. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8302921
Brown AJ et al. Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1836062
Harmon SD et al. Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820285
Horrobin DF Schizophrenia as a membrane lipid disorder which is expressed throughout the body. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888116
Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
Abbate R et al. n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888356
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
Yusof HM et al. Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18403189
Frøyland L et al. Hypotriacylglycerolemic component of fish oil. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430383