DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Hsiao HM et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. 2013 PLoS ONE pmid:23484005
Weise C et al. Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. 2013 Pediatr Allergy Immunol pmid:23577592
Chen J et al. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. 2013 Food Chem. Toxicol. pmid:23590892
Metherel AH et al. EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. 2013 Lipids pmid:23949919
Barros KV et al. Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. 2013 Clin Nutr pmid:23260750
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
Baum SJ EPA and DHA: distinct yet essential n-3 fatty acids. 2012 Sep-Oct J Clin Lipidol pmid:23009786
Castro González MI et al. [Renal patient's diet: Can fish be included?]. 2012 Sep-Oct Nutr Hosp pmid:23478696
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
Sanz París A et al. [Proposed profile of omega 3 fatty acids in enteral nutrition]. 2012 Nov-Dec Nutr Hosp pmid:23588426
Brown WV From the editor. 2012 Nov-Dec J Clin Lipidol pmid:23312044
Derosa G et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. 2012 Nov-Dec J Clin Lipidol pmid:23312051
Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Ling PR et al. Arachidonic acid and docosahexaenoic acid supplemented to an essential fatty acid-deficient diet alters the response to endotoxin in rats. 2012 Metab. Clin. Exp. pmid:21944266
Kornfeld S et al. Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. 2012 Carcinogenesis pmid:22114075
Liang W and Chikritzhs T Does light alcohol consumption during pregnancy improve offspring's cognitive development? 2012 Med. Hypotheses pmid:21985759
Nasiri AH et al. Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. 2012 Andrologia pmid:21951061
Luxwolda MF et al. A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. 2012 Eur J Nutr pmid:21952690
Drover JR et al. A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. 2012 Early Hum. Dev. pmid:22835597
Martinez-Micaelo N et al. Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. 2012 Biochem. J. pmid:21954853
Chew EY et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). 2012 Ophthalmology pmid:22840421
Vanlint SJ and Ried K Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. 2012 Maturitas pmid:22078660
Clària J et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. 2012 J. Immunol. pmid:22844113
Lin DC et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Mol. Pharmacol. pmid:22859723
Martin CR et al. The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. 2012 Aliment. Pharmacol. Ther. pmid:22129201
Tsushima T et al. Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. 2012 J Oleo Sci pmid:22864513
Carvalho-Wells AL et al. APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults. 2012 Am. J. Clin. Nutr. pmid:23134888
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Brown SP et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. 2012 ACS Med Chem Lett pmid:24900539
Mozaffarian D and Wu JH (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? 2012 J. Nutr. pmid:22279134
Maki KC and Rains TM Stearidonic acid raises red blood cell membrane eicosapentaenoic acid. 2012 J. Nutr. pmid:22279138
Whelan J et al. Effects of dietary stearidonic acid on biomarkers of lipid metabolism. 2012 J. Nutr. pmid:22279143
Wu JH et al. Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. 2012 Circulation pmid:22282329
Weylandt KH et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. 2012 Prostaglandins Other Lipid Mediat. pmid:22326554
Harlioglu AG et al. Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). 2012 Food Sci Technol Int pmid:22328124
Dawson K et al. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. 2012 J. Nutr. Biochem. pmid:21775114
Hofmanová J et al. Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. 2012 J. Nutr. Biochem. pmid:21775115
Kim YJ et al. Plasma phospholipid fatty acid composition in ischemic stroke: importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. 2012 Atherosclerosis pmid:23044095
Kitson AP et al. Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet. 2012 Appl Physiol Nutr Metab pmid:23050796
Quan-Xin F et al. Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn. 2012 BMC Gastroenterol pmid:23092159
Ritter JC and Budge SM Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. 2012 Lipids pmid:23096224
Chang YL et al. Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. 2012 Cell Transplant pmid:21669041
Tanaka T et al. Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. 2012 Lipids pmid:22411689
Shi T et al. Identification of a novel C22-∆4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. 2012 Biotechnol. Lett. pmid:22941368
D'Vaz N et al. Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. 2012 Pediatrics pmid:22945403
Francescato G et al. Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. 2012 Pediatr Obes pmid:22991250
Joseph MS et al. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. 2012 PLoS ONE pmid:22911773
Mitchell DC et al. Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. 2012 Chem. Phys. Lipids pmid:22405878
de Velasco PC et al. Nutritional restriction of omega-3 fatty acids alters topographical fine tuning and leads to a delay in the critical period in the rodent visual system. 2012 Exp. Neurol. pmid:22227060
Bonatto SJ et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. 2012 Lipids pmid:22160495
Yan J et al. Improving stability and activity of cross-linked enzyme aggregates based on polyethylenimine in hydrolysis of fish oil for enrichment of polyunsaturated fatty acids. 2012 Appl. Biochem. Biotechnol. pmid:22167690
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Stough C et al. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. 2012 Neurobiol. Aging pmid:21531481
Harris WS et al. Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. 2012 Atherosclerosis pmid:22727409
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Nakano M et al. CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. 2012 Mol. Pharmacol. pmid:22772592
Park Y et al. Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. 2012 Ann. Nutr. Metab. pmid:22776859
Rogerio AP et al. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. 2012 J. Immunol. pmid:22802419
Quiroga AD et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. 2012 Hepatology pmid:22806626
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Gruber JF et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. 2012 Nutr J pmid:22747713
Ewaschuk JB et al. Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. 2012 Lipids pmid:23054549
Schott CK and Huang DT ω-3 fatty acids, γ-linolenic acid, and antioxidants: immunomodulators or inert dietary supplements? 2012 Crit Care pmid:23176247
Wang DC et al. Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. 2012 Neurobiol. Aging pmid:20980076
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Sirot V et al. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. 2012 Nutr Metab Cardiovasc Dis pmid:20875947
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Pottala JV et al. Red blood cell fatty acids are associated with depression in a case-control study of adolescents. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22464051
Gladyshev MI et al. Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. 2012 J. Food Sci. pmid:23240970
Chen YJ et al. Docosahexaenoic acid suppresses the expression of FoxO and its target genes. 2012 J. Nutr. Biochem. pmid:22444500
Krishnamoorthy S et al. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. 2012 Am. J. Pathol. pmid:22449948
Gil-Sánchez A et al. Current understanding of placental fatty acid transport. 2012 Curr Opin Clin Nutr Metab Care pmid:22450774
Moon HJ et al. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. 2012 Ann. Nutr. Metab. pmid:22507833
Hughes BH et al. Fish oil fortification of soft goat cheese. 2012 J. Food Sci. pmid:22309698
Sierra S et al. Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish. 2012 Brain Res. Bull. pmid:22542883
Bazan NG et al. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. 2012 Exp. Neurol. pmid:22542947
Crawford MA and Broadhurst CL The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. 2012 Nutr Health pmid:22544773
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Galicia-Connolly E et al. Complementary, holistic, and integrative medicine: therapies for neurodevelopment in preterm infants. 2012 Pediatr Rev pmid:22659260
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Meldrum SJ et al. Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22572105
Labrousse VF et al. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. 2012 PLoS ONE pmid:22662127
Chiang N et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. 2012 Nature pmid:22538616
Gil-Campos M and Sanjurjo Crespo P Omega 3 fatty acids and inborn errors of metabolism. 2012 Br. J. Nutr. pmid:22591887
Lopez-Huertas E The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. 2012 Br. J. Nutr. pmid:22591892
Delgado-Lista J et al. Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. 2012 Br. J. Nutr. pmid:22591894
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