Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
Wang S et al. | Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. | 2014 | Clin Nutr | pmid:23672804 |
Tungen JE et al. | Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. | 2014 | J. Nat. Prod. | pmid:25247845 |
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:24834713 | |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
White PJ et al. | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. | 2014 | Nat. Med. | pmid:24813250 |
Balas L et al. | Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. | 2014 | Biochimie | pmid:24262603 |
Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
Pottala JV et al. | Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. | 2014 | Neurology | pmid:24453077 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Hashimoto M et al. | Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. | 2014 | J. Pharmacol. Sci. | pmid:24561447 |
Bauer I et al. | Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. | 2014 | Hum Psychopharmacol | pmid:24285504 |
Abdel-Dayem MA et al. | Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. | 2014 | Drugs R D | pmid:24733439 |
Höper AC et al. | Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. | 2014 | J. Nutr. | pmid:24285691 |
Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
Montgomery P et al. | Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. | 2014 | J Sleep Res | pmid:24605819 |
Walker CG et al. | Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. | 2014 | Br. J. Nutr. | pmid:24063767 |