| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Magnesium Deficiency | D008275 | 9 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colorectal Neoplasms | D015179 | 10 associated lipids |
| Optic Nerve Diseases | D009901 | 6 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Sepsis | D018805 | 11 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xie W et al. | ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. | 2016 | Lab. Invest. | pmid:26878131 |
| Croasdell A et al. | Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. | 2016 | J. Immunol. | pmid:26843331 |
| Berrueta L et al. | Stretching Impacts Inflammation Resolution in Connective Tissue. | 2016 | J. Cell. Physiol. | pmid:26588184 |
| Kim N et al. | Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production. | 2016 | Eur. J. Immunol. | pmid:26474728 |
| Wang ZQ et al. | Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. | 2016 | J. Cardiovasc. Pharmacol. | pmid:26657886 |
| Georgieva R et al. | Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. | 2016 | Langmuir | pmid:26794691 |
| Croasdell A et al. | Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. | 2016 | FASEB J. | pmid:27256622 |
| Arnardottir H et al. | Human milk proresolving mediators stimulate resolution of acute inflammation. | 2016 | Mucosal Immunol | pmid:26462421 |
| Jory J | Abnormal fatty acids in Canadian children with autism. | 2016 | Nutrition | pmid:26746679 |
| Park HG et al. | Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). | 2016 | FEBS Lett. | pmid:27543786 |
| Nagai T et al. | Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. | 2016 | PLoS ONE | pmid:27824904 |
| Graciano MF et al. | Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. | 2016 | J. Physiol. Biochem. | pmid:27474043 |
| Li R et al. | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. | 2016 | Mediators Inflamm. | pmid:28042205 |
| Suzuki-Kemuriyama N et al. | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2016 | PLoS ONE | pmid:27333187 |
| Fialkow J | Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. | 2016 | Am J Cardiovasc Drugs | pmid:27138439 |
| Wong BH et al. | Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. | 2016 | J. Biol. Chem. | pmid:27008858 |
| Gramer G et al. | Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27269713 |
| Pinçon A et al. | Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. | 2016 | J. Nutr. Biochem. | pmid:27239755 |
| Dagorn F et al. | Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. | 2016 | Mar Drugs | pmid:27231919 |
| Deng X et al. | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Biochim. Biophys. Acta | pmid:26873633 |
| Tian Y et al. | Bioconversion of Docosapentaenoic Acid in Human Cell Lines, Caco-2, HepG2, and THP-1. | 2016 | J Oleo Sci | pmid:27829615 |
| Wilding TJ et al. | Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains. | 2016 | J. Neurosci. | pmid:27559165 |
| Gao J et al. | Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. | 2016 | J. Nutr. Biochem. | pmid:27469996 |
| Snodgrass RG et al. | Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress. | 2016 | J. Nutr. Biochem. | pmid:27142735 |
| Seeger DR and Murphy EJ | Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. | 2016 | Lipids | pmid:26797754 |
| Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
| Qin X et al. | Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26802938 |
| Goda AA et al. | Astaxanthin and Docosahexaenoic Acid Reverse the Toxicity of the Maxi-K (BK) Channel Antagonist Mycotoxin Penitrem A. | 2016 | Mar Drugs | pmid:27834847 |
| Cerf ME and Herrera E | High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. | 2016 | Nutrients | pmid:26742067 |
| Andersen MK et al. | Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. | 2016 | PLoS Genet. | pmid:27341449 |
| Benabdoune H et al. | The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. | 2016 | Inflamm. Res. | pmid:27056390 |
| Medema S et al. | Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. | 2016 | Schizophr Bull | pmid:26385764 |
| Abeywardena MY et al. | Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. | 2016 | Nutrients | pmid:26742064 |
| Sui YH et al. | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | World J. Gastroenterol. | pmid:26937141 |
| Tran DQ et al. | Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. | 2016 | Mol. Cell. Endocrinol. | pmid:26923440 |
| Kondreddy VK and Kamatham AN | Celecoxib, a COX-2 inhibitor, synergistically potentiates the anti-inflammatory activity of docosahexaenoic acid in macrophage cell line. | 2016 | Immunopharmacol Immunotoxicol | pmid:26954392 |
| Devassy JG et al. | Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. | 2016 | Adv Nutr | pmid:27633106 |
| Nuez-OrtÃn WG et al. | Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. | 2016 | PLoS ONE | pmid:27556399 |
| Del Gobbo LC et al. | ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. | 2016 | JAMA Intern Med | pmid:27357102 |
| Metherel AH et al. | Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat. | 2016 | Biochim. Biophys. Acta | pmid:27263420 |
| Khaddaj-Mallat R et al. | Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. | 2016 | PLoS ONE | pmid:27935998 |
| Minihane AM | Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes. | 2016 | Nutrients | pmid:26950146 |
| Taha AY et al. | Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26869088 |
| Moriyama R et al. | Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. | 2016 | J. Reprod. Dev. | pmid:26853521 |
| Titos E et al. | Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. | 2016 | J. Immunol. | pmid:27647830 |
| Wang CS et al. | ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. | 2016 | Sci Rep | pmid:27064029 |
| Luo B et al. | Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis. | 2016 | J. Neurosci. | pmid:27629711 |
| Zhao Q et al. | Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats. | 2016 | Inflammation | pmid:27145782 |
| Barden A et al. | n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. | 2016 | Nutrients | pmid:27007392 |
| Zhao Q et al. | Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung. | 2016 | J Transl Med | pmid:27009328 |