Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reardon HT et al. | Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22398025 |
Zhang J et al. | Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23465412 |
Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Hashimoto M et al. | Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16165346 |
Gow RV et al. | Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19230637 |
Kruger MC and Schollum LM | Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16154334 |
Whelan J et al. | Docosahexaenoic acid: measurements in food and dietary exposure. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19493663 |
Das UN et al. | Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728172 |
Makrides M | Is there a dietary requirement for DHA in pregnancy? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19500960 |
Schuchardt JP et al. | Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21862301 |
Lien EL | Toxicology and safety of DHA. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19501496 |
Chapkin RS et al. | Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19502020 |
Nieminen LR et al. | Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. | 2006 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16959481 |
Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
Du Plooy WJ et al. | The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409770 |
Pakala R et al. | Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328332 |
Holub BJ | Docosahexaenoic acid (DHA) and cardiovascular disease risk factors. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19545988 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Smithers LG et al. | Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951004 |
Calder PC | The relationship between the fatty acid composition of immune cells and their function. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951005 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Russell KL et al. | Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23796971 |
Horrocks LA and Farooqui AA | Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041028 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Kawabata T et al. | Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21420843 |
Rousseau-Ralliard D et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo. | 2009 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19428232 |
Kim W et al. | n-3 polyunsaturated fatty acids--physiological relevance of dose. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20188532 |
Hall JA et al. | Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17081738 |
Sarri KO et al. | Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18258421 |
Levy BD | Resolvins and protectins: natural pharmacophores for resolution biology. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227865 |
McPhee S et al. | Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. | 2010 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20074924 |
Rahman T et al. | The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. | 2010 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20106645 |
Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
De Caterina R et al. | Omega-3 fatty acids and endothelial leukocyte adhesion molecules. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7540306 |
Burdge GC et al. | The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17693069 |
Hoffmire CA et al. | Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22472486 |
Kuipers RS et al. | Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425684 |
Chechi K et al. | Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20688254 |
Calder PC | Immunomodulation by omega-3 fatty acids. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18032006 |
Sethom MM et al. | Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20667702 |
Crawford MA et al. | A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23206328 |
Helmersson-Karlqvist J et al. | Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047909 |
Das UN et al. | Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482165 |
Otto SJ et al. | Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907133 |
Polozova A et al. | Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16837179 |
Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |