DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Neuralgia D009437 28 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Obesity D009765 29 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Proteinuria D011507 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Acute Lung Injury D055371 33 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Cataract D002386 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Burns D002056 34 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Heart Failure D006333 36 associated lipids
Lung Diseases D008171 37 associated lipids
Peritonitis D010538 38 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Hypotension D007022 41 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Asthma D001249 52 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Hashimoto M et al. Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16165346
Gow RV et al. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19230637
Kruger MC and Schollum LM Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16154334
Whelan J et al. Docosahexaenoic acid: measurements in food and dietary exposure. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19493663
Das UN et al. Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728172
Makrides M Is there a dietary requirement for DHA in pregnancy? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500960
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
Lien EL Toxicology and safety of DHA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19501496
Chapkin RS et al. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19502020
Nieminen LR et al. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16959481
Decsi T et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401433
Du Plooy WJ et al. The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1409770
Pakala R et al. Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328332
Holub BJ Docosahexaenoic acid (DHA) and cardiovascular disease risk factors. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545988
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Smithers LG et al. Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951004
Calder PC The relationship between the fatty acid composition of immune cells and their function. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951005
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Horrocks LA and Farooqui AA Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041028
Harris MA et al. Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487304
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
Rousseau-Ralliard D et al. Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19428232
Kim W et al. n-3 polyunsaturated fatty acids--physiological relevance of dose. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20188532
Hall JA et al. Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17081738
Sarri KO et al. Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18258421
Levy BD Resolvins and protectins: natural pharmacophores for resolution biology. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20227865
McPhee S et al. Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20074924
Rahman T et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106645
Tocher DR and Dick JR Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161581
De Caterina R et al. Omega-3 fatty acids and endothelial leukocyte adhesion molecules. 1995 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:7540306
Burdge GC et al. The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17693069
Hoffmire CA et al. Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22472486
Kuipers RS et al. Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425684
Chechi K et al. Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20688254
Calder PC Immunomodulation by omega-3 fatty acids. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18032006
Sethom MM et al. Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20667702
Crawford MA et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23206328
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Das UN et al. Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9482165
Otto SJ et al. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907133
Polozova A et al. Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16837179
Brouwer IA Omega-3 PUFA: good or bad for prostate cancer? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951003
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073