Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Teague WE et al. | Polyunsaturated lipids in membrane fusion events. | 2002 | Cell. Mol. Biol. Lett. | pmid:12097942 |
Barros MF et al. | Cord blood essential fatty acid and alpha-tocopherol in full-term newborns in a Northeast Brazil area. | 2002 | Int J Vitam Nutr Res | pmid:12098883 |
Hibbeln JR | Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. | 2002 | J Affect Disord | pmid:12103448 |
Minda H et al. | Systematic review of fatty acid composition of plasma phospholipids of venous cord blood in full-term infants. | 2002 | Eur J Nutr | pmid:12111050 |
Haubner LY et al. | Maternal dietary docosahexanoic acid content affects the rat pup auditory system. | 2002 | Brain Res. Bull. | pmid:12121805 |
Shmeeda H et al. | Heat acclimation in rats: modulation via lipid polyunsaturation. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12121852 |
Murayama K et al. | Fish oil (polyunsaturated fatty acid) prevents ischemic-induced injury in the mammalian retina. | 2002 | Exp. Eye Res. | pmid:12126941 |
Fam SS et al. | Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. | 2002 | J. Biol. Chem. | pmid:12133837 |
Benito Fernández J et al. | [The influence of human milk and various artificial formulae commercially available in Spain on the fatty acid status of infants in the first two months of life]. | 2002 | An. Esp. Pediatr. | pmid:12139873 |
Diaz O et al. | The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts. | 2002 | J. Biol. Chem. | pmid:12140281 |
Hansen RA et al. | Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. | 2002 Jul-Aug | J. Vet. Intern. Med. | pmid:12141309 |
Nestel P et al. | The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12145002 |
Jeffrey BG et al. | n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147619 |
Armstrong D et al. | Preparation of microspheres and incorporation of lipid hydroperoxide for sustained release studies. | 2002 | Methods Mol. Biol. | pmid:12152211 |
Akbar M and Kim HY | Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. | 2002 | J. Neurochem. | pmid:12153489 |
Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
Jensen CL and Heird WC | Lipids with an emphasis on long-chain polyunsaturated fatty acids. | 2002 | Clin Perinatol | pmid:12168241 |
RVitelli M et al. | Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes. | 2002 | Life Sci. | pmid:12175705 |
Turner ND et al. | Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis. | 2002 | Cancer Lett. | pmid:12183072 |
Berger A et al. | Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression. | 2002 | Genome Biol. | pmid:12184799 |
Sugimoto Y et al. | Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. | 2002 | Biol. Pharm. Bull. | pmid:12186415 |
Pilitsis JG et al. | Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. | 2002 | J. Neurosurg. | pmid:12186453 |
pmid:12195273 | ||||
Cheruku SR et al. | Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning. | 2002 | Am. J. Clin. Nutr. | pmid:12198007 |
Kimura S et al. | Docosahexaenoic acid attenuated hypertension and vascular dementia in stroke-prone spontaneously hypertensive rats. | 2002 Sep-Oct | Neurotoxicol Teratol | pmid:12200199 |
Doolan GK et al. | Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK. | 2002 | FASEB J. | pmid:12206993 |
Wallis JG et al. | Polyunsaturated fatty acid synthesis: what will they think of next? | 2002 | Trends Biochem. Sci. | pmid:12217522 |
Weiler HA and Fitzpatrick-Wong SC | Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. | 2002 | J. Nutr. | pmid:12221227 |
Minda H et al. | Effect of different types of feeding on fatty acid composition of erythrocyte membrane lipids in full-term infants. | 2002 | Acta Paediatr. | pmid:12222708 |
Fernandes MX et al. | Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane. | 2002 | Biochim. Biophys. Acta | pmid:12225849 |
Arsenov DV et al. | [Effects of complexes of alpha-fetoprotein and amphiphilic docosaenoic acid derivatives on the humoral immune response in C57BL/6 mice]. | 2002 May-Jun | Eksp Klin Farmakol | pmid:12227097 |
Yang P et al. | Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. | 2002 | Anal. Biochem. | pmid:12234478 |
Goel DP et al. | Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12234824 |
Innis SM and Dyer RA | Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. | 2002 | J. Lipid Res. | pmid:12235185 |
Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
Calder PC | Dietary modification of inflammation with lipids. | 2002 | Proc Nutr Soc | pmid:12296294 |
Chapkin RS et al. | Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures. | 2002 | Clin. Exp. Immunol. | pmid:12296847 |
Burdge GC et al. | Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain. | 2002 | Br. J. Nutr. | pmid:12323087 |
Ghys A et al. | Red blood cell and plasma phospholipid arachidonic and docosahexaenoic acid levels at birth and cognitive development at 4 years of age. | 2002 | Early Hum. Dev. | pmid:12324186 |
Williard DE et al. | Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324227 |
Martin RE et al. | Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324228 |
Krasevec JM et al. | Maternal and infant essential fatty acid status in Havana, Cuba. | 2002 | Am. J. Clin. Nutr. | pmid:12324298 |
Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | 2002 | Mol. Vis. | pmid:12355064 |
Sergeeva M et al. | Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation. | 2002 | J. Neurochem. | pmid:12358772 |
AbuGhazaleh AA et al. | Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. | 2002 | J. Dairy Sci. | pmid:12362459 |
Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
Hulbert AJ et al. | Acyl composition of muscle membranes varies with body size in birds. | 2002 | J. Exp. Biol. | pmid:12364409 |
Mathews SA et al. | Comparison of triglycerides and phospholipids as supplemental sources of dietary long-chain polyunsaturated fatty acids in piglets. | 2002 | J. Nutr. | pmid:12368399 |
Acar N et al. | Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. | 2002 | J. Nutr. | pmid:12368410 |
Brzustowicz MR et al. | Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. | 2002 | Biochemistry | pmid:12369842 |
Wu T et al. | Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. | 2002 | Lipids | pmid:12371750 |
Saito M and Kubo K | An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats. | 2002 | Ann. Nutr. Metab. | pmid:12378040 |
Quan LG and Cha JK | Preparation of isoprostanes and neuroprostanes. | 2002 | J. Am. Chem. Soc. | pmid:12381179 |
Ye D et al. | Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388664 |
Rodriguez de Turco EB et al. | Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. | 2002 | J. Neurochem. | pmid:12390513 |
Woodman RJ et al. | Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. | 2002 | Am. J. Clin. Nutr. | pmid:12399272 |
Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
Glew RH et al. | The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401435 |
Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
Nordøy A | Statins and omega-3 fatty acids in the treatment of dyslipidemia and coronary heart disease. | 2002 | Minerva Med. | pmid:12410168 |
van Wezel-Meijler G et al. | Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. | 2002 | Acta Paediatr. | pmid:12412870 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
Bowen RA and Clandinin MT | Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. | 2002 | J. Neurochem. | pmid:12421348 |
Abhyankar B | Further reduction in mortality following myocardial infarction. | 2002 | Hosp Med | pmid:12422496 |
Montine TJ et al. | Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. | 2002 | J. Neurochem. | pmid:12423256 |
Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
Meireles LA et al. | Increase of the yields of eicosapentaenoic and docosahexaenoic acids by the microalga Pavlova lutheri following random mutagenesis. | 2003 | Biotechnol. Bioeng. | pmid:12432580 |
Wang L and Muttucumaru S | Separation of biosynthetic polyunsaturated fatty acid (PUFA) with supercritical fluid. | 2002 | Biotechnol Annu Rev | pmid:12436919 |
Kearns SD and Haag M | The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445489 |
Andersson A et al. | Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12450886 |
Passi S et al. | Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish. | 2002 | J. Agric. Food Chem. | pmid:12452651 |
Pratt VC et al. | Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. | 2002 | Br. J. Cancer | pmid:12454764 |
Wang YW et al. | Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. | 2002 | Poult. Sci. | pmid:12455601 |
Guallar E et al. | Mercury, fish oils, and the risk of myocardial infarction. | 2002 | N. Engl. J. Med. | pmid:12456850 |
Bourre JM and Dumont O | The administration of pig brain phospholipids versus soybean phospholipids in the diet during the period of brain development in the rat results in greater increments of brain docosahexaenoic acid. | 2002 | Neurosci. Lett. | pmid:12459515 |
Furuya H et al. | Effect of ethanol and docosahexaenoic acid on nerve growth factor-induced neurite formation and neuron specific growth-associated protein gene expression in PC12 cells. | 2002 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:12462067 |
Diep QN et al. | PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. | 2002 | Hypertension | pmid:12468571 |
Seebungkert B and Lynch JW | Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. | 2002 | Eur. J. Neurosci. | pmid:12473076 |
Igarashi T et al. | Determination of docosahexaenoic acid and n-3 fatty acids in refined fish oils by 1H-NMR spectroscopy: IUPAC interlaboratory study. | 2002 Nov-Dec | J AOAC Int | pmid:12477198 |
Woodman RJ et al. | Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. | 2003 | Atherosclerosis | pmid:12482554 |
Amiano P et al. | Very-long-chain omega-3 fatty acids as markers for habitual fish intake in Spain. | 2002 | IARC Sci. Publ. | pmid:12484164 |
Baker SD et al. | Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. | 2002 | J. Natl. Cancer Inst. | pmid:12488482 |
Hashimoto M et al. | [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491779 |
Catalan J et al. | Cognitive deficits in docosahexaenoic acid-deficient rats. | 2002 | Behav. Neurosci. | pmid:12492301 |
Siddiqui RA et al. | Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. | 2003 | Biochem. J. | pmid:12492401 |
Yep YL et al. | Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. | 2002 | Asia Pac J Clin Nutr | pmid:12495260 |
Briscoe CP et al. | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. | 2003 | J. Biol. Chem. | pmid:12496284 |
Cerbone AM et al. | [EPA and DHA ethyl esters: potential mechanisms of antischemic action]. | 1999 | Cardiologia | pmid:12497815 |
Favrelière S et al. | DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. | 2003 Mar-Apr | Neurobiol. Aging | pmid:12498957 |
Francois CA et al. | Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. | 2003 | Am. J. Clin. Nutr. | pmid:12499346 |
Woodman RJ et al. | Docosahexaenoic acid but not eicosapentaenoic acid increases LDL particle size in treated hypertensive type 2 diabetic patients. | 2003 | Diabetes Care | pmid:12502701 |
Kramer JA et al. | Transcription profiling in rat liver in response to dietary docosahexaenoic acid implicates stearoyl-coenzyme a desaturase as a nutritional target for lipid lowering. | 2003 | J. Nutr. | pmid:12514267 |
Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
Rousseau D et al. | Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12521943 |
Wang Y et al. | Docosahexaenoic acid inhibits cytokine-induced expression of P-selectin and neutrophil adhesion to endothelial cells. | 2003 | Eur. J. Pharmacol. | pmid:12524156 |
De Swaaf ME et al. | High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. | 2003 | Biotechnol. Bioeng. | pmid:12529880 |
Park Y and Harris W | EPA, but not DHA, decreases mean platelet volume in normal subjects. | 2002 | Lipids | pmid:12530552 |
Brenner RR | Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538079 |
Qiu X | Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538082 |