Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. | 2013 | Adv Nutr | pmid:24228198 |
Lotrich FE et al. | Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. | 2013 | J Psychosom Res | pmid:24182638 |
Pande G et al. | Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. | 2013 | J. Agric. Food Chem. | pmid:24117100 |
Murphy EJ | A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. | 2013 | J. Neurochem. | pmid:24117623 |
Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
Méndez L et al. | Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. | 2013 | Free Radic. Biol. Med. | pmid:23159545 |
Cooke M et al. | Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. | 2013 | Mol. Cell. Endocrinol. | pmid:23159987 |
Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
Gustafson KM et al. | Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23433688 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
Kondo T et al. | Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. | 2013 | Cell Stem Cell | pmid:23434393 |
MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
GarcÃa-Layana A et al. | Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. | 2013 | Nutrients | pmid:23434908 |
Usami M et al. | Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. | 2013 | Clin Nutr | pmid:23068014 |
Kimura AK and Kim HY | Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. | 2013 | J. Lipid Res. | pmid:23071296 |
Khaled M et al. | Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. | 2013 | J. Periodontol. | pmid:23398023 |
Pettit LK et al. | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. | 2013 | Lipids Health Dis | pmid:23398903 |
Sugasini D and Lokesh BR | Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. | 2013 | Mol. Cell. Biochem. | pmid:23812902 |
Fukui M et al. | EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. | 2013 | J. Cell. Biochem. | pmid:22903547 |
Stark MJ et al. | Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. | 2013 | Reproduction | pmid:23813449 |
Rupp TP et al. | Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. | 2013 | Cardiology | pmid:23816637 |
Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
Friedman AN et al. | Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. | 2013 | Am. J. Nephrol. | pmid:23816975 |
Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
Gódor-Kacsándi A et al. | Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. | 2013 | Acta Physiol Hung | pmid:23524180 |
Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
Simões T et al. | Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. | 2013 | J. Food Sci. | pmid:23551246 |
Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
Kagan ML et al. | Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. | 2013 | Lipids Health Dis | pmid:23855409 |
Mizia-Stec K et al. | N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. | 2013 | Cardiol J | pmid:24469870 |
Merendino N et al. | Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. | 2013 | Biomed Res Int | pmid:23762838 |
Hunina LM et al. | [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. | 2013 | Fiziol Zh | pmid:23713352 |
Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
Gow RV et al. | Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664595 |
Ramprasath VR et al. | Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. | 2013 | Lipids Health Dis | pmid:24304605 |
Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
Dabkowski ER et al. | Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. | 2013 | Cardiovasc Drugs Ther | pmid:24013804 |
Porta A et al. | Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. | 2013 | Chem. Phys. Lipids | pmid:23895793 |
Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
Yee LD et al. | The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. | 2013 | Mol Nutr Food Res | pmid:23213007 |
Kilpinen L et al. | Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. | 2013 | J. Lipid Res. | pmid:23271708 |
Qu L et al. | Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. | 2013 | Appl. Biochem. Biotechnol. | pmid:24061873 |
Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
Becerir C et al. | The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. | 2013 | J Enzyme Inhib Med Chem | pmid:22591320 |
Siddiqui RA et al. | Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. | 2013 | BMC Cancer | pmid:24034496 |