Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Herzberg GR et al. | Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. | 1992 | Biochim. Biophys. Acta | pmid:1531932 |
Nenseter MS et al. | Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans. | 1992 | Arterioscler. Thromb. | pmid:1532127 |
Irie M and Sakimoto M | Fat characteristics of pigs fed fish oil containing eicosapentaenoic and docosahexaenoic acids. | 1992 | J. Anim. Sci. | pmid:1532172 |
Innis SM et al. | n-6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadian preschool children. | 2004 | Am. J. Clin. Nutr. | pmid:15321820 |
Parent CA et al. | Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes. | 1992 | J. Biol. Chem. | pmid:1532390 |
Speake BK and Deans EA | Biosynthesis of oleic, arachidonic and docosahexaenoic acids from their C18 precursors in the yolk sac membrane of the avian embryo. | 2004 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15325342 |
Van Anholt RD et al. | Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L. | 2004 | J. Exp. Biol. | pmid:15326218 |
Gordon WC et al. | Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis. | 1992 | Curr. Eye Res. | pmid:1532774 |
Innis SM | Plasma and red blood cell fatty acid values as indexes of essential fatty acids in the developing organs of infants fed with milk or formulas. | 1992 | J. Pediatr. | pmid:1532829 |
Treen M et al. | Effect of docosahexaenoic acid on membrane fluidity and function in intact cultured Y-79 retinoblastoma cells. | 1992 | Arch. Biochem. Biophys. | pmid:1533110 |
Grønn M et al. | Effects of dietary purified eicosapentaenoic acid (20:5 (n-3)) and docosahexaenoic acid (22:6(n-3)) on fatty acid desaturation and oxidation in isolated rat liver cells. | 1992 | Biochim. Biophys. Acta | pmid:1533162 |
Baker RR and Chang HY | The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: a degree of selectivity is shown for docosahexaenoate release. | 1992 | Biochim. Biophys. Acta | pmid:1533163 |
Hoffman DR et al. | Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. | 2004 | J. Nutr. | pmid:15333721 |
Seal JR and Porter NA | Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. | 2004 | Anal Bioanal Chem | pmid:15338093 |
Mucke L and Pitas RE | Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD. | 2004 | Neuron | pmid:15339638 |
Calon F et al. | Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. | 2004 | Neuron | pmid:15339646 |
Bønaa KH et al. | Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. | 1992 | Arterioscler. Thromb. | pmid:1534256 |
Lee SS et al. | Requirement of PPARalpha in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation. | 2004 | J. Lipid Res. | pmid:15342691 |
Shaikh SR et al. | Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study. | 2004 | Biophys. J. | pmid:15345554 |
Giltay EJ et al. | Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. | 2004 | J. Endocrinol. | pmid:15350182 |
Momchilova S et al. | Resolution of triacylglycerol positional isomers by reversed-phase high-performance liquid chromatography. | 2004 | J Sep Sci | pmid:15352724 |
Harris WS et al. | Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. | 2004 | Circulation | pmid:15353491 |
Bucci KK | Fish oil supplements. | 1992 | Am Pharm | pmid:1535475 |
Lindsey S et al. | Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. | 1992 | J. Lipid Res. | pmid:1535648 |
Leaf AA et al. | Factors affecting long-chain polyunsaturated fatty acid composition of plasma choline phosphoglycerides in preterm infants. | 1992 | J. Pediatr. Gastroenterol. Nutr. | pmid:1535657 |
Ghebremeskel K et al. | Type 1 diabetes compromises plasma arachidonic and docosahexaenoic acids in newborn babies. | 2004 | Lipids | pmid:15357021 |
Calviello G et al. | n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. | 2004 | Carcinogenesis | pmid:15358633 |
Dennis CL | Preventing postpartum depression part I: a review of biological interventions. | 2004 | Can J Psychiatry | pmid:15362251 |
Berson EL et al. | Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. | 2004 | Arch. Ophthalmol. | pmid:15364708 |
Berson EL et al. | Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. | 2004 | Arch. Ophthalmol. | pmid:15364709 |
Calviello G et al. | Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. | 2005 | Cancer Chemother. Pharmacol. | pmid:15365767 |
Ding WQ et al. | Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. | 2004 | Mol. Cancer Ther. | pmid:15367705 |
Raimondi L et al. | n-3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive rats. | 2005 | Eur J Nutr | pmid:15368071 |
Bairati I et al. | Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. | 1992 | Circulation | pmid:1537131 |
Baumgartner M et al. | Enhancement of arsenic trioxide-mediated apoptosis using docosahexaenoic acid in arsenic trioxide-resistant solid tumor cells. | 2004 | Int. J. Cancer | pmid:15382055 |
Innis SM | Polyunsaturated fatty acids in human milk: an essential role in infant development. | 2004 | Adv. Exp. Med. Biol. | pmid:15384565 |
Pacetti D et al. | High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15386630 |
Gordge MP et al. | Anti-platelet therapy in diabetic and non-diabetic progressive renal failure. | 1992 | Clin. Nephrol. | pmid:1541067 |
Huan M et al. | Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. | 2004 | Biol. Psychiatry | pmid:15450784 |
Ethier I et al. | Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors. | 2004 | Biol. Psychiatry | pmid:15450789 |
Mitre R et al. | Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. | 2004 | Theriogenology | pmid:15451263 |
Valentine RC and Valentine DL | Omega-3 fatty acids in cellular membranes: a unified concept. | 2004 | Prog. Lipid Res. | pmid:15458813 |
Alexopoulos E et al. | Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. | 2004 | Ren Fail | pmid:15462115 |
Strokin M et al. | Role of Ca2+-independent phospholipase A2 and n-3 polyunsaturated fatty acid docosahexaenoic acid in prostanoid production in brain: perspectives for protection in neuroinflammation. | 2004 | Int. J. Dev. Neurosci. | pmid:15465285 |
Subbaiah PV et al. | Evidence for altered positional specificity of LCAT in vivo: studies with docosahexaenoic acid feeding in humans. | 2004 | J. Lipid Res. | pmid:15466370 |
Buckley R et al. | Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. | 2004 | Br. J. Nutr. | pmid:15469651 |
Danbara N et al. | Dietary effects of conjugated docosahexaenoic acid on N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. | 2004 | Oncol. Rep. | pmid:15492796 |
Harries M et al. | Phase I/II study of DHA-paclitaxel in combination with carboplatin in patients with advanced malignant solid tumours. | 2004 | Br. J. Cancer | pmid:15494716 |
Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
Foley JM et al. | Fatty acids and exercise affect glucose transport but not tumour growth in F-344 rats. | 2004 | Can J Appl Physiol | pmid:15507696 |
Love R | Good fats prevent dendritic damage in mouse model of AD. | 2004 | Lancet Neurol | pmid:15515234 |
Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
Wynter MP et al. | Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs. | 2004 Sep-Oct | In Vivo | pmid:15523890 |
Furimsky A et al. | Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid-containing phosphatidylcholine compared to washed capacitated mouse sperm. | 2005 | Biol. Reprod. | pmid:15525814 |
Martin DA et al. | Prenatal dietary docosahexaenoic acid supplementation in combination with protein restriction does not affect blood pressure in adult Wistar rats. | 2004 | Nutr Neurosci | pmid:15526988 |
Speake BK et al. | Evidence for placental transfer of lipids during gestation in the viviparous lizard, Pseudemoia entrecasteauxii. | 2004 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:15528170 |
Fan YY et al. | Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production. | 2004 | J. Immunol. | pmid:15528352 |
Jellema A et al. | Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. | 2004 | Eur. J. Clin. Invest. | pmid:15530150 |
Wassall SR et al. | Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. | 2004 | Chem. Phys. Lipids | pmid:15530450 |
Giltay EJ et al. | Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. | 2004 | Am. J. Clin. Nutr. | pmid:15531662 |
Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
Aslan A and Triadafilopoulos G | Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. | 1992 | Am. J. Gastroenterol. | pmid:1553930 |
Virtanen JK et al. | Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15539625 |
Adiv OE et al. | Influence of co-administration of oral insulin and docosahexaenoic acid in mice. | 2004 | J. Nutr. Biochem. | pmid:15542356 |
Hastings N et al. | Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). | 2004 Sep-Oct | Mar. Biotechnol. | pmid:15549653 |
Eschen O et al. | Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids. | 2004 | Nutr Metab Cardiovasc Dis | pmid:15553594 |
Ko YH et al. | Cloning and expression of Tsaiya duck liver fatty acid binding protein. | 2004 | Poult. Sci. | pmid:15554058 |
Tanabe Y et al. | Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554911 |
Manav M et al. | Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. | 2004 Nov-Dec | Nutrition | pmid:15561485 |
Miura Y et al. | Docosahexaenoic acid induces apoptosis via the Bax-independent pathway in HL-60 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15564688 |
Katsura K et al. | Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. | 2004 | Brain Res. | pmid:15567345 |
Das UN | Can perinatal supplementation of long-chain polyunsaturated fatty acids prevents schizophrenia in adult life? | 2004 | Med. Sci. Monit. | pmid:15567990 |
DeMar JC et al. | Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. | 2004 | J. Neurochem. | pmid:15569256 |
Belayev L et al. | Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. | 2005 | Stroke | pmid:15569878 |
Jia Q et al. | Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice. | 2004 | J. Nutr. | pmid:15570035 |
Danbara N et al. | Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. | 2004 | Nutr Cancer | pmid:15572300 |
Hibbeln JR et al. | Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence. | 2004 | Biol. Psychiatry | pmid:15576068 |
Hussein N et al. | Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. | 2005 | J. Lipid Res. | pmid:15576848 |
Rupp H et al. | Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. | 2004 | Herz | pmid:15580322 |
Cao DH et al. | Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. | 2004 | Pharmacol. Biochem. Behav. | pmid:15582673 |
Whalley LJ et al. | Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids. | 2004 | Am. J. Clin. Nutr. | pmid:15585782 |
Huang BX et al. | Probing conformational changes of human serum albumin due to unsaturated fatty acid binding by chemical cross-linking and mass spectrometry. | 2005 | Biochem. J. | pmid:15588254 |
Dijck-Brouwer DA et al. | Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589396 |
Puskás LG et al. | Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain. | 2004 | Biochimie | pmid:15589691 |
Verlengia R et al. | Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells. | 2004 | J. Nutr. Biochem. | pmid:15590269 |
Sun L et al. | Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618634 |
Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
Engler MM et al. | Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study. | 2004 | Int J Clin Pharmacol Ther | pmid:15624283 |
Maldjian A et al. | Changes in sperm quality and lipid composition during cryopreservation of boar semen. | 2005 | Theriogenology | pmid:15626408 |
Denys A et al. | n-3 PUFAs modulate T-cell activation via protein kinase C-alpha and -epsilon and the NF-kappaB signaling pathway. | 2005 | J. Lipid Res. | pmid:15627650 |
McCabe AJ et al. | Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1. | 2005 | J. Nutr. Biochem. | pmid:15629236 |
Nagata J et al. | Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. | 2004 | Biofactors | pmid:15630273 |
Hamam F and Shahidi F | Production and stability of structured lipids from algal oils and capric acid. | 2004 | Biofactors | pmid:15630303 |
Kaul U et al. | Fish oil supplements for prevention of restenosis after coronary angioplasty. | 1992 | Int. J. Cardiol. | pmid:1563884 |
Hofmanová J et al. | Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis. | 2005 | Cancer Lett. | pmid:15639338 |
Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
Hossain Z et al. | Effect of polyunsaturated fatty acid-enriched phosphatidylcholine and phosphatidylserine on butyrate-induced growth inhibition, differentiation and apoptosis in Caco-2 cells. | 2006 Mar-Apr | Cell Biochem. Funct. | pmid:15648055 |
Zemski Berry KA and Murphy RC | Free radical oxidation of plasmalogen glycerophosphocholine containing esterified docosahexaenoic acid: structure determination by mass spectrometry. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650405 |
Milne GL et al. | The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650409 |
Stark KD et al. | Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. | 2005 | Alcohol. Clin. Exp. Res. | pmid:15654301 |