DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alexander JW | Influence of EPA and DHA intravenous fat emulsions on nitrogen retention and protein kinetics in burned rats. | 1999 | Nutrition | pmid:9990585 |
| Sasaki T et al. | Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. | 1999 | Biochim. Biophys. Acta | pmid:9989281 |
| Krugman S and Law P | Breastfeeding and IQ. | 1999 | Pediatrics | pmid:9988628 |
| Matorras R et al. | Biochemical markers of n-3 long chain polyunsaturated fatty acid intake during pregnancy. | 1998 | Clin Exp Obstet Gynecol | pmid:9987571 |
| Cellini M et al. | Fatty acid use in glaucomatous optic neuropathy treatment. | 1998 | Acta Ophthalmol Scand Suppl | pmid:9972342 |
| Azavache V et al. | [The liver as a source of essential long chain polyunsaturated fatty acids for postnatal brain development in the rat]. | 1998 | Arch Latinoam Nutr | pmid:9951533 |
| Araya Araya J et al. | [Differences in percent composition of long chain polyunsaturated fatty acids in maternal-fetal erythrocytes in term and preterm infants]. | 1998 | Arch Latinoam Nutr | pmid:9951532 |
| Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
| Nourooz-Zadeh J et al. | F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. | 1999 | J. Neurochem. | pmid:9930747 |
| Hirafuji M et al. | Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9920344 |
| Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9918868 |
| Hashimoto M et al. | The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. | 1999 | J. Nutr. | pmid:9915878 |
| Baur LA et al. | Relationships between maternal risk of insulin resistance and the child's muscle membrane fatty acid composition. | 1999 | Diabetes | pmid:9892230 |
| Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
| Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
| Perin N et al. | Dietary lipid composition modifies intestinal morphology and nutrient transport in young rats. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:9890468 |
| Kollman KA et al. | Dietary lipids influence intestinal adaptation after massive bowel resection. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:9890467 |
| Marzo I et al. | Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888202 |
| Mani I et al. | Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. | 1999 | J. Invest. Dermatol. | pmid:9886262 |
| Bernoud N et al. | Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. | 1999 | J. Neurochem. | pmid:9886086 |
| Akedo I et al. | Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules. | 1998 | Jpn. J. Clin. Oncol. | pmid:9879296 |
| Vaagenes H et al. | Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. | 1998 | Lipids | pmid:9870909 |
| Hansen JB et al. | Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. | 1998 | Lipids | pmid:9870908 |
| Ishihara K et al. | Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. | 1998 | Lipids | pmid:9870906 |
| Ward GR et al. | Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats. | 1998 | J. Nutr. | pmid:9868196 |
| Cho HP et al. | Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. | 1999 | J. Biol. Chem. | pmid:9867867 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
| Huster D et al. | Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. | 1998 | Biochemistry | pmid:9860844 |
| Martin RE | Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. | 1998 | J. Neurosci. Res. | pmid:9856864 |
| Rotstein NP et al. | Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9856786 |
| Yuan C et al. | The unique lipid composition of gecko (Gekko Gekko) photoreceptor outer segment membranes. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9854823 |
| Saha SK et al. | Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid. | 1998 | Jpn. J. Physiol. | pmid:9852344 |
| Helland IB et al. | Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. | 1998 | Eur J Clin Nutr | pmid:9846598 |
| Allen PC and Danforth HD | Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. | 1998 | Poult. Sci. | pmid:9835336 |
| MartÃnez M and Mougan I | Fatty acid composition of human brain phospholipids during normal development. | 1998 | J. Neurochem. | pmid:9832152 |
| Gibson RA and Makrides M | The role of long chain polyunsaturated fatty acids (LCPUFA) in neonatal nutrition. | 1998 | Acta Paediatr. | pmid:9825965 |
| Price SA and Tisdale MJ | Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid. | 1998 | Cancer Res. | pmid:9809986 |
| Schofield M et al. | Cholesterol versus cholesterol sulfate: effects on properties of phospholipid bilayers containing docosahexaenoic acid. | 1998 | Chem. Phys. Lipids | pmid:9807808 |
| Kubo K et al. | Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9805370 |
| Menard CR et al. | Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. | 1998 | J. Neurochem. | pmid:9798942 |
| Scott DT et al. | Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? | 1998 | Pediatrics | pmid:9794989 |
| Rodriguez A et al. | Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks. | 1998 | Am. J. Obstet. Gynecol. | pmid:9790399 |
| Morley R | Nutrition and cognitive development. | 1998 | Nutrition | pmid:9785354 |
| Maurage C et al. | Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants. | 1998 | Biol. Neonate | pmid:9784633 |
| Ikeda I et al. | Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. | 1998 | Lipids | pmid:9778137 |
| Jenski LJ et al. | The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro. | 1998 | Lipids | pmid:9778134 |
| Macleod JC et al. | The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsaturated fatty acids. | 1998 | Eur. J. Pharmacol. | pmid:9774258 |
| Lii CK et al. | Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774170 |
| Andriamampandry M et al. | Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K. | 1998 | C. R. Acad. Sci. III, Sci. Vie | pmid:9766191 |
| Mitchell DC et al. | Why is docosahexaenoic acid essential for nervous system function? | 1998 | Biochem. Soc. Trans. | pmid:9765880 |