DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Croasdell A et al. | Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. | 2016 | J. Immunol. | pmid:26843331 |
| Abdulnour RE et al. | Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. | 2016 | Mucosal Immunol | pmid:26647716 |
| Berrueta L et al. | Stretching Impacts Inflammation Resolution in Connective Tissue. | 2016 | J. Cell. Physiol. | pmid:26588184 |
| López-Luna P et al. | Fate of orally administered radioactive fatty acids in the late-pregnant rat. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26714850 |
| Wang ZQ et al. | Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. | 2016 | J. Cardiovasc. Pharmacol. | pmid:26657886 |
| Georgieva R et al. | Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. | 2016 | Langmuir | pmid:26794691 |
| Inoue Y et al. | Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. | 2016 | Crit. Care Med. | pmid:26509319 |
| Arnardottir H et al. | Human milk proresolving mediators stimulate resolution of acute inflammation. | 2016 | Mucosal Immunol | pmid:26462421 |
| Park HG et al. | Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). | 2016 | FEBS Lett. | pmid:27543786 |
| Nagai T et al. | Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. | 2016 | PLoS ONE | pmid:27824904 |
| Li R et al. | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. | 2016 | Mediators Inflamm. | pmid:28042205 |
| Suzuki-Kemuriyama N et al. | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2016 | PLoS ONE | pmid:27333187 |
| Kim SM et al. | Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. | 2016 | EBioMedicine | pmid:27322464 |
| Fialkow J | Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. | 2016 | Am J Cardiovasc Drugs | pmid:27138439 |
| Wong BH et al. | Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. | 2016 | J. Biol. Chem. | pmid:27008858 |
| Pinçon A et al. | Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. | 2016 | J. Nutr. Biochem. | pmid:27239755 |
| Dagorn F et al. | Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. | 2016 | Mar Drugs | pmid:27231919 |
| Tian Y et al. | Bioconversion of Docosapentaenoic Acid in Human Cell Lines, Caco-2, HepG2, and THP-1. | 2016 | J Oleo Sci | pmid:27829615 |
| Seeger DR and Murphy EJ | Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. | 2016 | Lipids | pmid:26797754 |
| Qin X et al. | Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26802938 |
| Andersen MK et al. | Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. | 2016 | PLoS Genet. | pmid:27341449 |
| Benabdoune H et al. | The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. | 2016 | Inflamm. Res. | pmid:27056390 |
| Abeywardena MY et al. | Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. | 2016 | Nutrients | pmid:26742064 |
| Tran DQ et al. | Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. | 2016 | Mol. Cell. Endocrinol. | pmid:26923440 |
| Bernhard W et al. | Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. | 2016 | Eur J Nutr | pmid:26363610 |
| Devassy JG et al. | Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. | 2016 | Adv Nutr | pmid:27633106 |
| Mason RP et al. | Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. | 2016 | Biochim. Biophys. Acta | pmid:27718370 |
| Moriyama R et al. | Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. | 2016 | J. Reprod. Dev. | pmid:26853521 |
| Luo B et al. | Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis. | 2016 | J. Neurosci. | pmid:27629711 |
| Barden A et al. | n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. | 2016 | Nutrients | pmid:27007392 |
| Zhao Q et al. | Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung. | 2016 | J Transl Med | pmid:27009328 |
| Prieto P et al. | Activation of autophagy in macrophages by pro-resolving lipid mediators. | 2015 | Autophagy | pmid:26506892 |
| Cox R et al. | Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. | 2015 | PLoS ONE | pmid:26317859 |
| de Oliveira JR et al. | AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4. | 2015 | Biomed Res Int | pmid:26075216 |
| Dalli J et al. | Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. | 2015 | FASEB J. | pmid:25713027 |
| Cespedes E et al. | Adipose tissue n-3 fatty acids and metabolic syndrome. | 2015 | Eur J Clin Nutr | pmid:25097001 |
| Ting HC et al. | Polyunsaturated fatty acids incorporation into cardiolipin in H9c2 cardiac myoblast. | 2015 | J. Nutr. Biochem. | pmid:25866137 |
| Keim SA and Branum AM | Dietary intake of polyunsaturated fatty acids and fish among US children 12-60 months of age. | 2015 | Matern Child Nutr | pmid:24034437 |
| Musto AE et al. | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. | 2015 | PLoS ONE | pmid:25617763 |
| Dorninger F et al. | Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. | 2015 | Biochim. Biophys. Acta | pmid:25463479 |
| Krishnamoorthy N et al. | Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. | 2015 | J. Immunol. | pmid:25539814 |
| Askari M et al. | Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. | 2015 | Clin Transl Oncol | pmid:25351172 |
| Jones PJ et al. | High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. | 2015 | Atherosclerosis | pmid:25528432 |
| Chen CT et al. | Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. | 2015 | Sci Rep | pmid:26511533 |
| Holen E et al. | Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. | 2015 | Fish Shellfish Immunol. | pmid:26003739 |
| Park HG et al. | The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. | 2015 | FASEB J. | pmid:26065859 |
| Chew EY et al. | Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. | 2015 | JAMA | pmid:26305649 |
| Dodington DW et al. | Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. | 2015 | J. Nutr. | pmid:26423734 |
| Bobiński R and Mikulska M | The ins and outs of maternal-fetal fatty acid metabolism. | 2015 | Acta Biochim. Pol. | pmid:26345097 |
| Hieda K et al. | Pharmacological effect of functional foods with a hypotensive action. | 2015 | Nippon Yakurigaku Zasshi | pmid:26165340 |