DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Lee SM et al. Characterization of lecithin isolated from anchovy (Engraulis japonica) residues deoiled by supercritical carbon dioxide and organic solvent extraction. 2012 J. Food Sci. pmid:22757698
Petrie JR et al. Metabolic engineering plant seeds with fish oil-like levels of DHA. 2012 PLoS ONE pmid:23145108
Nasiri AH et al. Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. 2012 Andrologia pmid:21951061
Luxwolda MF et al. A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. 2012 Eur J Nutr pmid:21952690
Martinez-Micaelo N et al. Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. 2012 Biochem. J. pmid:21954853
Hong WK et al. Growth of the oleaginous microalga Aurantiochytrium sp. KRS101 on cellulosic biomass and the production of lipids containing high levels of docosahexaenoic acid. 2012 Bioprocess Biosyst Eng pmid:21959581
Vanlint SJ and Ried K Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. 2012 Maturitas pmid:22078660
Clària J et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. 2012 J. Immunol. pmid:22844113
Lin DC et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Mol. Pharmacol. pmid:22859723
Martin CR et al. The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. 2012 Aliment. Pharmacol. Ther. pmid:22129201
Tsushima T et al. Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. 2012 J Oleo Sci pmid:22864513
Begum G et al. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. 2012 J. Neurochem. pmid:22129278
López-Alarcón M et al. Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. 2012 Nutrition pmid:22079797
Skulas-Ray AC et al. Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. 2012 Ann Behav Med pmid:22865498
Le HD et al. Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038210
Towhidi A and Parks JE Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. 2012 J. Assist. Reprod. Genet. pmid:22869241
Tillman EM et al. Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038211
Fasano E et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. 2012 Biochim. Biophys. Acta pmid:22898250
Schmitt D et al. Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. 2012 Food Chem. Toxicol. pmid:22898615
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Betancor MB et al. Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. 2012 Lipids pmid:23086553
Weylandt KH et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. 2012 Prostaglandins Other Lipid Mediat. pmid:22326554
Hou L et al. Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart. 2012 Cardiovasc Diabetol pmid:23057715
Harlioglu AG et al. Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). 2012 Food Sci Technol Int pmid:22328124
Dawson K et al. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. 2012 J. Nutr. Biochem. pmid:21775114
Swanson D et al. Omega-3 fatty acids EPA and DHA: health benefits throughout life. 2012 Adv Nutr pmid:22332096
Hofmanová J et al. Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. 2012 J. Nutr. Biochem. pmid:21775115
Berson EL et al. ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. 2012 Arch. Ophthalmol. pmid:22332205
Beezhold BL and Johnston CS Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. 2012 Nutr J pmid:22333737
Rondanelli M et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. 2012 Nutr Neurosci pmid:22334085
Rockett BD et al. Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. 2012 J. Lipid Res. pmid:22315394
Tanaka T et al. Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. 2012 Lipids pmid:22411689
Bragt MC and Mensink RP Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. 2012 Nutr Metab Cardiovasc Dis pmid:21429719
Hajjaji N et al. DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. 2012 Nutr Cancer pmid:23035949
Contreras GA et al. Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. 2012 J. Dairy Sci. pmid:23040031
Skender B et al. Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. 2012 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23069883
Xue B et al. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. 2012 PLoS ONE pmid:23071533
Joseph MS et al. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. 2012 PLoS ONE pmid:22911773
Mas E et al. Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. 2012 Clin. Chem. pmid:22912397
Schmitt D et al. Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. 2012 Food Chem. Toxicol. pmid:22960629
Waldron MK et al. Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. 2012 Lipids pmid:22252853
Huang TY et al. A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. 2012 Bioresour. Technol. pmid:22929740
Browning LM et al. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. 2012 Am. J. Clin. Nutr. pmid:22932281
Feng Z et al. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. 2012 Antioxid. Redox Signal. pmid:21905985
Moreno-Indias I et al. The effect of diet and DHA addition on the sensory quality of goat kid meat. 2012 Meat Sci. pmid:21907501
Alvarez-Nölting R et al. Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. 2012 Neurochem. Res. pmid:21909958
Mitchell DC et al. Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. 2012 Chem. Phys. Lipids pmid:22405878
Yan J et al. Improving stability and activity of cross-linked enzyme aggregates based on polyethylenimine in hydrolysis of fish oil for enrichment of polyunsaturated fatty acids. 2012 Appl. Biochem. Biotechnol. pmid:22167690
Mil-Homens D et al. The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia. 2012 FEMS Microbiol. Lett. pmid:22150831
Rupp H et al. Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". 2012 Can. J. Physiol. Pharmacol. pmid:22188440
Peters BS et al. The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. 2012 Clin Ther pmid:22212377
Munro IA and Garg ML Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. 2012 Br. J. Nutr. pmid:22214842
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Basselin M et al. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. 2012 Brain Res. Bull. pmid:22178644
Bang S et al. 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. 2012 Br. J. Pharmacol. pmid:21718307
Deike E et al. The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. 2012 J Ren Nutr pmid:22285316
Landmark K and Alm CS [Fish and omega-3 fatty acids and heart failure]. 2012 Tidsskr. Nor. Laegeforen. pmid:23736195
Stough C et al. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. 2012 Neurobiol. Aging pmid:21531481
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Rogerio AP et al. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. 2012 J. Immunol. pmid:22802419
Quiroga AD et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. 2012 Hepatology pmid:22806626
Gruber JF et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. 2012 Nutr J pmid:22747713
Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
Johnson M et al. Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. 2012 Atten Defic Hyperact Disord pmid:22753087
Quinn EA and Kuzawa CW A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. 2012 Acta Paediatr. pmid:22759234
Turk HF et al. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. 2012 PLoS ONE pmid:22761867
Hacioglu G et al. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. 2012 Folia Histochem. Cytobiol. pmid:22763967
Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Sirot V et al. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. 2012 Nutr Metab Cardiovasc Dis pmid:20875947
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Gladyshev MI et al. Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. 2012 J. Food Sci. pmid:23240970
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Gil-Sánchez A et al. Current understanding of placental fatty acid transport. 2012 Curr Opin Clin Nutr Metab Care pmid:22450774
Oblozinský M et al. New pharmaceutical insights related to the pathways of PUFAs. 2012 Ceska Slov Farm pmid:23251954
Moon HJ et al. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. 2012 Ann. Nutr. Metab. pmid:22507833
Calandria JM et al. Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. 2012 J. Biol. Chem. pmid:22511762
Lifschitz C New actions for old nutrients. 2012 Acta Sci Pol Technol Aliment pmid:22493160
Kwak SM et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. 2012 Arch. Intern. Med. pmid:22493407
Liu SH et al. Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. 2012 Brain Res. pmid:22440676
Lorenzetti A et al. Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. 2012 Acta Biomed pmid:23393918
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
Meldrum SJ et al. Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22572105
Glover KE et al. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. 2012 J. Dairy Sci. pmid:22612917
Lopez-Huertas E The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. 2012 Br. J. Nutr. pmid:22591892
Delgado-Lista J et al. Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. 2012 Br. J. Nutr. pmid:22591894
Corsetto PA et al. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. 2012 Cell Biochem. Biophys. pmid:22622660
Serra-Majem L et al. Dietary methods and biomarkers of omega 3 fatty acids: a systematic review. 2012 Br. J. Nutr. pmid:22591904
Bell S et al. The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. 2012 Clin. Nephrol. pmid:22595386
Larqué E et al. Omega 3 fatty acids, gestation and pregnancy outcomes. 2012 Br. J. Nutr. pmid:22591905
Hajjaji N et al. Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. 2012 Cancer Chemother. Pharmacol. pmid:22610354
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. 2012 Br. J. Nutr. pmid:22591907
Njoroge SW et al. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. 2012 J. Lipid Res. pmid:22095831
Angulo J et al. Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. 2012 J. Sci. Food Agric. pmid:22549272
Wielinga PY et al. Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. 2012 Mol Nutr Food Res pmid:22611002
Calder PC Long-chain fatty acids and inflammation. 2012 Proc Nutr Soc pmid:22369781
Kelley DS and Adkins Y Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. 2012 Proc Nutr Soc pmid:22369859
Bernstein AM et al. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. 2012 J. Nutr. pmid:22113870