DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Storey A et al. Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. 2005 J. Invest. Dermatol. pmid:15654981
Marszalek JR et al. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. 2005 J. Biol. Chem. pmid:15655248
Katsumata T and Katayama Y [Icosapentanoic acid (EPA), docosahexanoic acid (DHA)]. 2004 Nippon Rinsho pmid:15658280
Chiu LC et al. Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells. 2004 Ann. N. Y. Acad. Sci. pmid:15659818
Yamamoto K et al. Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents. 2005 Bioorg. Med. Chem. Lett. pmid:15664804
Sul D et al. Benzene increases the ratio of arachidonic acids to docosahexaenoic acids and inhibits the de novo synthesis of ceramide in the rat liver. 2005 Jan-Feb J Appl Toxicol pmid:15669040
Du ZY et al. Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. 2004 Lipids pmid:15669760
Verlengia R et al. Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. 2004 Lipids pmid:15669761
Mutch DM et al. An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. 2005 FASEB J. pmid:15670975
Gerbi A et al. Dose dependent accretion of docosahexaenoic acid (DHA) in cardiac membranes of rats fed egg yolk powder enriched in DHA. 2004 Cell. Mol. Biol. (Noisy-le-grand) pmid:15672470
Gleize B et al. Docosahexaenoic acid-enriched egg phospholipids supplementation induces accretion of arachidonic acid in rat blood lipids. 2004 Cell. Mol. Biol. (Noisy-le-grand) pmid:15672471
Turner AJ et al. Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration. 2004 Ann. N. Y. Acad. Sci. pmid:15681797
Szabó A et al. Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. 2005 Poult. Sci. pmid:15685949
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Rajamoorthi K et al. Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. 2005 J. Am. Chem. Soc. pmid:15686391
Beblo S et al. Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. 2005 Pediatrics pmid:15687427
Økland HM et al. Proximate composition, fatty acid and lipid class composition of the muscle from deep-sea teleosts and elasmobranchs. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15694592
Okuda N et al. Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study. 2005 Atherosclerosis pmid:15694947
Li H et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. 2005 Kidney Int. pmid:15698426
Geelen A et al. Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. 2005 Am. J. Clin. Nutr. pmid:15699229
Narayanan NK et al. A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. 2005 Int. J. Oncol. pmid:15703837
Gronert K et al. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. 2005 J. Biol. Chem. pmid:15708862
Serhan CN Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. 2005 Curr Opin Clin Nutr Metab Care pmid:15716788
Groh-Wargo S et al. Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. 2005 Pediatr. Res. pmid:15718356
García-Calatayud S et al. Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. 2005 Pediatr. Res. pmid:15718358
Kojima M et al. Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. 2005 Am. J. Epidemiol. pmid:15718482
Brinsko SP et al. Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. 2005 Theriogenology pmid:15725455
Anderson RE and Penn JS Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. 2004 Lipids pmid:15726827
Serhan CN et al. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. 2004 Lipids pmid:15726828
Mollard RC et al. Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit. 2005 J. Nutr. pmid:15735085
Hashimoto M et al. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. 2005 J. Nutr. pmid:15735092
Valenzuela A et al. Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats. 2005 Jan-Feb Ann. Nutr. Metab. pmid:15735367
Aro TL et al. Fatty acids and fat-soluble vitamins in salted herring (Clupea harengus) products. 2005 J. Agric. Food Chem. pmid:15740028
Itomura M et al. The effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trial. 2005 J. Nutr. Biochem. pmid:15741051
Goirand F et al. Effect of dietary docosahexaenoic acid on the endothelium-dependent vasorelaxation in diabetic rats. 2005 Clin. Exp. Pharmacol. Physiol. pmid:15743401
Van Biervliet S et al. Docosahexaenoic acid trials in cystic fibrosis: a review of the rationale behind the clinical trials. 2005 J. Cyst. Fibros. pmid:15752678
Alessandri JM et al. Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. 2004 Nov-Dec Reprod. Nutr. Dev. pmid:15762297
Kuipers RS et al. High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15763440
Niu SL et al. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. 2005 Biochemistry pmid:15766276
Shim SM et al. Mercury and omega-3 fatty acids in retail fish sandwiches. 2005 J. Food Prot. pmid:15771197
Draganov DI et al. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. 2005 J. Lipid Res. pmid:15772423
Denkins Y et al. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. 2005 J. Lipid Res. pmid:15772428
Simon HB On call. I was impressed by your July 2004 article on fish oil, and I'm thinking of taking it. I remember that my mother gave me a spoonful of cod liver oil every day. Would it be a good thing for me to have today? 2005 Harv Mens Health Watch pmid:15773012
Berry CB et al. Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid. 2005 Brain Res. pmid:15777760
Engler MM et al. Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). 2005 Am. J. Cardiol. pmid:15781019
Bazan HE Cellular and molecular events in corneal wound healing: significance of lipid signalling. 2005 Exp. Eye Res. pmid:15781273
Araseki M et al. Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid. 2005 Biosci. Biotechnol. Biochem. pmid:15784975
Cha MC et al. Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity. 2005 BMC Pharmacol. pmid:15788091
Lim GP et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. 2005 J. Neurosci. pmid:15788759
Kim HJ et al. Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. 2005 J. Cell. Physiol. pmid:15795939
Thomas CP and Heard CM In vitro transcutaneous delivery of ketoprofen and essential polyunsaturated fatty acids from a fish oil vehicle incorporating 1,8-cineole. 2005 Jan-Feb Drug Deliv pmid:15801715
Gederaas OA et al. Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. 2005 Photochem. Photobiol. Sci. pmid:15803209
Zhang Q and Ma Y [Determination of EPA and DHA in marine microalgaes by GC]. 2004 Se Pu pmid:15807130
Fickl H et al. Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. 2005 Clin. Exp. Immunol. pmid:15807851
Ren H et al. Blood mononuclear cells and platelets have abnormal fatty acid composition in homozygous sickle cell disease. 2005 Ann. Hematol. pmid:15809883
Clandinin MT et al. Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. 2005 J. Pediatr. pmid:15812447
Birch EE et al. Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. 2005 Am. J. Clin. Nutr. pmid:15817866
Abuissa H et al. Autonomic function, omega-3, and cardiovascular risk. 2005 Chest pmid:15821175
Patten GS et al. Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil. 2005 Lipids pmid:15825832
Goyens PL et al. Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. 2005 J. Lipid Res. pmid:15834128
Innis SM Essential fatty acid transfer and fetal development. 2005 Placenta pmid:15837071
Weatherill AR et al. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. 2005 J. Immunol. pmid:15843537
Lytle JS et al. Stability of a commercially prepared fish oil (omega-3 fatty acid) laboratory rodent diet. 1992 Nutr Cancer pmid:1584711
Woods MN Role of n-3 fatty acids in prevention of disease complications in patients with HIV. 2005 Jan-Mar Nutr Clin Care pmid:15850231
Montine TJ and Morrow JD Fatty acid oxidation in the pathogenesis of Alzheimer's disease. 2005 Am. J. Pathol. pmid:15855630
Kunesová M et al. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. 2006 Physiol Res pmid:15857162
Carta G et al. Recurrent miscarriage associated with antiphospholipid antibodies: prophylactic treatment with low-dose aspirin and fish oil derivates. 2005 Clin Exp Obstet Gynecol pmid:15864938
Aïd S et al. Dietary docosahexaenoic acid [22: 6(n-3)] as a phospholipid or a triglyceride enhances the potassium chloride-evoked release of acetylcholine in rat hippocampus. 2005 J. Nutr. pmid:15867273
Lim SY et al. Lead exposure and (n-3) fatty acid deficiency during rat neonatal development affect subsequent spatial task performance and olfactory discrimination. 2005 J. Nutr. pmid:15867275
Maurin AC et al. Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. 2005 Calcif. Tissue Int. pmid:15868283
Hirano H et al. The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages. 2005 Oncol. Rep. pmid:15870941
Djoussé L et al. Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. 2005 J. Am. Coll. Cardiol. pmid:15893192
Yin H et al. Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. 2005 J. Biol. Chem. pmid:15894799
Dhein S et al. Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids. 2005 Naunyn Schmiedebergs Arch. Pharmacol. pmid:15900514
Menendez JA et al. Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. 2005 Eur. J. Cancer Prev. pmid:15901996
Van Maldergem L et al. Orthotopic liver transplantation from a living-related donor in an infant with a peroxisome biogenesis defect of the infantile Refsum disease type. 2005 J. Inherit. Metab. Dis. pmid:15902563
Filburn CR and Griffin D Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. 2005 Vet. Ther. pmid:15906268
Bazan NG Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. 2005 Brain Pathol. pmid:15912889
Duncan RE et al. Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. 2005 Cancer Lett. pmid:15914273
Chen S et al. Importance of polyunsaturated acyl chains in chlorpromazine interaction with phosphatidylserines: a 13C and 31P solid-state NMR study. 2005 Biophys. Chem. pmid:15921844
Hamazaki K et al. Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial. 2005 Nutrition pmid:15925295
Maki KC et al. Lipid responses to a dietary docosahexaenoic acid supplement in men and women with below average levels of high density lipoprotein cholesterol. 2005 J Am Coll Nutr pmid:15930485
Lin YH et al. Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma. 2005 J. Lipid Res. pmid:15930513
Li Q et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. 2005 J. Lipid Res. pmid:15930520
Dabadie H et al. Moderate intake of myristic acid in sn-2 position has beneficial lipidic effects and enhances DHA of cholesteryl esters in an interventional study. 2005 J. Nutr. Biochem. pmid:15936650
Wilkinson P et al. Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. 2005 Atherosclerosis pmid:15939062
Speake BK and Wood NA Timing of incorporation of docosahexaenoic acid into brain and muscle phospholipids during precocial and altricial modes of avian development. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15939318
Seidel A et al. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15943605
Meng LP et al. [Relationship between maternal DHA intake and DHA status and development of fetus and infant]. 2005 Wei Sheng Yan Jiu pmid:15952672
Liu BH et al. Effect of docosahexaenoic acid and arachidonic acid on the expression of adipocyte determination and differentiation-dependent factor 1 in differentiating porcine adipocytes. 2005 J. Anim. Sci. pmid:15956459
Butovich IA et al. Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid. 2005 Lipids pmid:15957250
Senkal M et al. Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue. 2005 Jul-Aug JPEN J Parenter Enteral Nutr pmid:15961678
Hichami A et al. Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. 2005 Am. J. Respir. Cell Mol. Biol. pmid:15961724
Lu L et al. Effects of different types of oxidative stress in RPE cells. 2006 J. Cell. Physiol. pmid:15965958
Obajimi O et al. Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. 2005 Pharmacol. Res. pmid:15967385
Salem N et al. Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. 2005 Exp. Eye Res. pmid:15967432
Tritt KL et al. Chemometric discrimination among wild and cultured age-0 largemouth bass, black crappies, and white crappies based on fatty acid composition. 2005 J. Agric. Food Chem. pmid:15969511
Min Y et al. Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. 2005 Diabet. Med. pmid:15975108
Diau GY et al. The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. 2005 BMC Med pmid:15975147
Bowen RA and Clandinin MT Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain. 2005 Br. J. Nutr. pmid:15975158