DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Brown SP et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. 2012 ACS Med Chem Lett pmid:24900539
Bobiński R and Mikulska M The ins and outs of maternal-fetal fatty acid metabolism. 2015 Acta Biochim. Pol. pmid:26345097
Lorenzetti A et al. Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. 2012 Acta Biomed pmid:23393918
Ebrahimi M et al. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. 2009 Acta Cardiol pmid:19593941
Flock S et al. Syntheses of some polyunsaturated sulfur- and oxygen-containing fatty acids related to eicosapentaenoic and docosahexaenoic acids. 1999 Acta Chem. Scand. pmid:10377950
Crespo-Armas A et al. Changes produced by experimental hypothyroidism in fibre type composition and mitochondrial properties of rat slow and fast twitch muscles. 1994 Acta Cient. Venez. pmid:8525758
Jung JY et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. 2014 Acta Derm. Venereol. pmid:24553997
Kragballe K and Fogh K A low-fat diet supplemented with dietary fish oil (Max-EPA) results in improvement of psoriasis and in formation of leukotriene B5. 1989 Acta Derm. Venereol. pmid:2563604
Sumida C et al. Interaction of unsaturated fatty acids with rat liver glucocorticoid receptors: studies to localize the site of interaction. 1993 Acta Endocrinol. pmid:8237254
Sanjurjo P et al. Influence of fatty fish intake during pregnancy in the polyunsaturated fatty acids of erythrocyte phospholipids in the mother at labor and newborn infant. 1995 Acta Obstet Gynecol Scand pmid:7660762
Hacioglu G et al. The role of docosahexaenoic acid on visual evoked potentials in one kidney-one clip hypertension. 2006 Acta Ophthalmol Scand pmid:16879569
Cellini M et al. Fatty acid use in glaucomatous optic neuropathy treatment. 1998 Acta Ophthalmol Scand Suppl pmid:9972342
Suzuki Y et al. Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. 1996 Acta Paediatr Jpn pmid:8942014
Chirouze V et al. Red blood cell fatty acid composition in low-birth-weight infants fed either human milk or formula during the first months of life. 1994 Acta Paediatr Suppl pmid:7734796
Agostoni C et al. Long-chain polyunsaturated fatty acids in human milk. 1999 Acta Paediatr Suppl pmid:10569226
van Wezel-Meijler G et al. Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. 2002 Acta Paediatr. pmid:12412870
Minda H et al. Effect of different types of feeding on fatty acid composition of erythrocyte membrane lipids in full-term infants. 2002 Acta Paediatr. pmid:12222708
Westerberg AC et al. Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. 2011 Acta Paediatr. pmid:20624152
Nyuar KB et al. Milk of northern Sudanese mothers whose traditional diet is high in carbohydrate contains low docosahexaenoic acid. 2010 Acta Paediatr. pmid:20618167
Decsi T et al. Fatty acid composition of human milk in Hungary. 2000 Acta Paediatr. pmid:11106060
Khedr EM et al. Neural maturation of breastfed and formula-fed infants. 2004 Acta Paediatr. pmid:15244219
Rosenfeld E et al. IPD meta-analysis shows no effect of LC-PUFA supplementation on infant growth at 18 months. 2009 Acta Paediatr. pmid:18691337
Xiang M et al. Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: diet, breast milk and infant growth. 2005 Acta Paediatr. pmid:16303692
Shoji H et al. Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. 2011 Acta Paediatr. pmid:21366690
Clandinin MT et al. Assessment of feeding different amounts of arachidonic and docosahexaenoic acids in preterm infant formulas on the fatty acid content of lipoprotein lipids. 1999 Acta Paediatr. pmid:10503691
Jørgensen MH et al. The role of long-chain polyunsaturated fatty acids in neonatal nutrition. 1999 Acta Paediatr. pmid:10503696
Quinn EA and Kuzawa CW A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. 2012 Acta Paediatr. pmid:22759234
Smuts CM et al. Smoking and alcohol use during pregnancy affects preterm infants' docosahexaenoic acid (DHA) status. 1999 Acta Paediatr. pmid:10447136
Leichsenring M et al. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. 1995 Acta Paediatr. pmid:7633146
Xiang M et al. Composition of long chain polyunsaturated fatty acids in human milk and growth of young infants in rural areas of northern China. 1999 Acta Paediatr. pmid:10102142
Gibson RA and Makrides M The role of long chain polyunsaturated fatty acids (LCPUFA) in neonatal nutrition. 1998 Acta Paediatr. pmid:9825965
Swenne I et al. Essential fatty acid status in teenage girls with eating disorders and weight loss. 2011 Acta Paediatr. pmid:21362034
Lai LH et al. Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells. 2009 Acta Pharmacol. Sin. pmid:19262555
Gódor-Kacsándi A et al. Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. 2013 Acta Physiol Hung pmid:23524180
Tanaka Y et al. Effects of exercise on platelet and aortic functions in aged rats. 2003 Acta Physiol. Scand. pmid:14510779
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Zajdel A et al. Polyunsaturated fatty acids alter expression of genes encoding antioxidant enzymes in A549 cells exposed to doxorubicin. 2010 Nov-Dec Acta Pol Pharm pmid:21229890
Lifschitz C New actions for old nutrients. 2012 Acta Sci Pol Technol Aliment pmid:22493160
Stoeckel K et al. Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids. 2011 Acta Vet. Scand. pmid:22024384
Taugbøl O et al. An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. 1996 Acta Vet. Scand. pmid:8996873
Szabó A et al. Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. 2012 Acta. Biol. Hung. pmid:22695520
Shingu T et al. Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). 1988 Adv Alcohol Subst Abuse pmid:2975919
Park NH Triglycerides & omega-3s. Prescription omega-3 fatty acids are now among the hypertriglyceridemia therapies. 2010 Adv NPs PAs pmid:21319452
Cederholm T et al. ω-3 fatty acids in the prevention of cognitive decline in humans. 2013 Adv Nutr pmid:24228198
Fleming JA and Kris-Etherton PM The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. 2014 Adv Nutr pmid:25398754
Kalupahana NS et al. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. 2011 Adv Nutr pmid:22332072
Swanson D et al. Omega-3 fatty acids EPA and DHA: health benefits throughout life. 2012 Adv Nutr pmid:22332096
Valentine CJ Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. 2012 Adv Nutr pmid:22585914
Devassy JG et al. Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. 2016 Adv Nutr pmid:27633106
Rupp H Omacor (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia. 2009 Adv Ther pmid:19629408
Gruenwald J et al. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. 2009 Adv Ther pmid:19756416
Singh A and Ward OP Microbial production of docosahexaenoic acid (DHA, C22:6). 1997 Adv. Appl. Microbiol. pmid:9342829
Bazan NG Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. 2008 Adv. Exp. Med. Biol. pmid:18188926
Kanan Y et al. An in-vivo assay to identify compounds protective against light induced apoptosis. 2008 Adv. Exp. Med. Biol. pmid:18188929
Agbaga MP et al. Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid. 2010 Adv. Exp. Med. Biol. pmid:20238022
Tanito M et al. Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. 2010 Adv. Exp. Med. Biol. pmid:20238060
Calandria JM and Bazan NG Neuroprotectin D1 modulates the induction of pro-inflammatory signaling and promotes retinal pigment epithelial cell survival during oxidative stress. 2010 Adv. Exp. Med. Biol. pmid:20238071
Decsi T et al. Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. 2005 Adv. Exp. Med. Biol. pmid:16137113
Anderson RE et al. Conservation of docosahexaenoic acid in the retina. 1992 Adv. Exp. Med. Biol. pmid:1386176
Bazan NG et al. Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process. 1992 Adv. Exp. Med. Biol. pmid:1386177
Innis SM Polyunsaturated fatty acids in human milk: an essential role in infant development. 2004 Adv. Exp. Med. Biol. pmid:15384565
Reich EE et al. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. 2002 Adv. Exp. Med. Biol. pmid:12664634
Youssef J et al. Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. 2002 Adv. Exp. Med. Biol. pmid:12664639
Reich EE et al. Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. 2001 Adv. Exp. Med. Biol. pmid:11764949
Agostoni C et al. Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. 2001 Adv. Exp. Med. Biol. pmid:11787675
Gibson RA and Makrides M Long-chain polyunsaturated fatty acids in breast milk: are they essential? 2001 Adv. Exp. Med. Biol. pmid:11787705
Smit EN et al. Docosahexaenoic acid (DHA) status of breastfed malnourished infants and their mothers in North Pakistan. 2000 Adv. Exp. Med. Biol. pmid:11065099
Lauritizen L et al. Dietary fish and the docosahexaenoic acid (DHA) content of human milk. 2000 Adv. Exp. Med. Biol. pmid:11065103
Savino F et al. Arachidonic (AA) and docosahexaenoic (DHA) acid content in healthy infants fed with an HA milk formula supplemented with LCPUFA and in breast fed infants. 2000 Adv. Exp. Med. Biol. pmid:11065107
Decsi T et al. Low contribution of docosahexaenoic acid to the fatty acid composition of mature human milk in Hungary. 2000 Adv. Exp. Med. Biol. pmid:11065108
Lopez-Alarcon M et al. Illness-induced anorexia in the breast-fed infants. Role of IL-1beta and TNF-alpha. 2000 Adv. Exp. Med. Biol. pmid:11065112
Sebaldt RJ and Marignani P Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. 1997 Adv. Exp. Med. Biol. pmid:9547650
Marosvölgyi T et al. Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. 2009 Adv. Exp. Med. Biol. pmid:19536675
Berge RK et al. Hypolipidemic 3-thia fatty acids. Fatty acid oxidation and ketogenesis in rat liver under proliferation of mitochondria and peroxisomes. 1999 Adv. Exp. Med. Biol. pmid:10709636
Berge K et al. Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture. 1999 Adv. Exp. Med. Biol. pmid:10709646
Madsen L et al. EPA and DHA possess different metabolic properties. 1999 Adv. Exp. Med. Biol. pmid:10709658
Moore SA et al. Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines. 1999 Adv. Exp. Med. Biol. pmid:10667320
Morrow JD et al. Formation of novel isoprostane-like compounds from docosahexaenoic acid. 1999 Adv. Exp. Med. Biol. pmid:10667351
Farooqui AA et al. Plasmalogens, docosahexaenoic acid and neurological disorders. 2003 Adv. Exp. Med. Biol. pmid:14713251
Bazan NG Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. 2006 Adv. Exp. Med. Biol. pmid:17249620
Moore SA Cerebral endothelium and astrocytes cooperate in supplying docosahexaenoic acid to neurons. 1993 Adv. Exp. Med. Biol. pmid:8333338
Siriwardhana N et al. Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. 2012 Adv. Food Nutr. Res. pmid:22361189
Lee TH and Arm JP The effects of a fish oil enriched diet on experimentally-induced and clinical asthma. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2546399
Hirai A et al. Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2546401
Codde JP et al. Effects of fish oil "Max EPA" on blood pressures and prostanoid metabolism of spontaneously hypertensive rats during salt loading. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960180
Kobayashi S et al. Changes of hemorrheological properties by highly purified DHA in normal subjects. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960200
Tremoli E et al. Effects of EPA and DHA ethylesters on plasma fatty acids and on platelets, PMN and monocytes in healthy volunteers. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1847768
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Titova OE et al. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. 2013 Age (Dordr) pmid:22791395
Pomponi MF et al. Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? 2011 Ageing Res. Rev. pmid:20920611
Denis I et al. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. 2013 Ageing Res. Rev. pmid:23395782
Currais A et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. 2014 Aging Cell pmid:24341874
Yi L et al. [Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]. 2007 Ai Zheng pmid:18076787
DoÄ­chinova A [Neovin + docosahexaenoic acid-supplement for pregnant and breastfeeding women]. 2008 Akush Ginekol (Sofiia) pmid:19227777
Retterstøl K et al. Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol. 2000 Alcohol pmid:10946154
Zheng Z et al. Effect of ganglioside GM1 on ethanol-induced changes in the incorporation of free fatty acids into membrane phospholipids in mouse brain. 1997 Nov-Dec Alcohol Alcohol. pmid:9463723
Wainwright PE et al. Effects of prenatal ethanol and long-chain n-3 fatty acid supplementation on development in mice. 2. Fatty acid composition of brain membrane phospholipids. 1990 Alcohol. Clin. Exp. Res. pmid:2143055
Pawlosky RJ et al. Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. 2001 Alcohol. Clin. Exp. Res. pmid:11781509
Garcia MC et al. Effects of chronic ethanol on the mobilization of arachidonate and docosahexaenoate stimulated by the type 2A serotonin receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in C6 glioma cells. 1997 Alcohol. Clin. Exp. Res. pmid:9394119
Stark KD et al. Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. 2005 Alcohol. Clin. Exp. Res. pmid:15654301