DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Madden J et al. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. 2011 Annu. Rev. Nutr. pmid:21568708
Yang R et al. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. 2011 Curr Protoc Immunol pmid:22048801
Musto AE et al. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. 2011 Epilepsia pmid:21569016
Corsetto PA et al. Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. 2011 Lipids Health Dis pmid:21569413
Asensio-Sánchez VM [Essential polyunsaturated fatty acids]. 2011 Arch Soc Esp Oftalmol pmid:21569923
Eckert GP et al. Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. 2011 Biochim. Biophys. Acta pmid:21036142
Bonnet N and Ferrari SL Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. 2011 J. Nutr. Biochem. pmid:21036590
Yates CM et al. Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells. 2011 J. Nutr. pmid:21613456
Freeman MP et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. 2011 Menopause pmid:21037490
Mills JD et al. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. 2011 Neurosurgery pmid:21135750
Bilal S et al. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. 2011 Biochim. Biophys. Acta pmid:21616147
Hamazaki-Fujita N et al. Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task. 2011 Brain Res. pmid:21616479
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Vinayavekhin N and Saghatelian A Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. 2011 J. Am. Chem. Soc. pmid:21973308
Wei MY and Jacobson TA Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. 2011 Curr Atheroscler Rep pmid:21975919
Turgut S et al. The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. 2011 J Basic Clin Physiol Pharmacol pmid:22865430
Golub N et al. Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. 2011 Med. Hypotheses pmid:21981905
Sanden M et al. Atlantic salmon (Salmo salar L.) as a net producer of long-chain marine ω-3 fatty acids. 2011 J. Agric. Food Chem. pmid:22017199
Kumosani TA and Moselhy SS Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. 2011 Hum Exp Toxicol pmid:20488854
Hung ND et al. Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. 2011 Inflammation pmid:20490641
Ruusunen A et al. Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. 2011 Eur J Nutr pmid:20574779
Yui K et al. [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. 2011 Nihon Shinkei Seishin Yakurigaku Zasshi pmid:21800702
Sullivan JC et al. Modeling the primary oxidation in commercial fish oil preparations. 2011 Lipids pmid:21104333
Shulse CN and Allen EE Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment. 2011 Environ. Microbiol. pmid:21105981
Koletzko B et al. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. 2011 Am. J. Clin. Nutr. pmid:21106917
Lu FS et al. Oxidative stability of marine phospholipids in the liposomal form and their applications. 2011 Lipids pmid:21088919
Mozaffarian D et al. Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. 2011 Ann. Intern. Med. pmid:21810709
Rioux FM et al. Relationship between maternal DHA and iron status and infants' cognitive performance. 2011 Can J Diet Pract Res pmid:21645426
Torshin IIu et al. [Systematic analysis of molecular mechanisms of action of omega-3 polyunsaturated fatty acids on arrhythmia]. 2011 Kardiologiia pmid:21649594
Palmer CD et al. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. 2011 J. Leukoc. Biol. pmid:21653234
Madec S et al. CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. 2011 Drug Metab. Dispos. pmid:21778351
Flachs P et al. Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. 2011 Diabetologia pmid:21779874
Molinari R et al. The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. 2011 Cancer Immunol. Immunother. pmid:21779875
Lai LH et al. [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21781602
Brignardello J et al. Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. 2011 Arch Latinoam Nutr pmid:22308941
Serhan CN and Petasis NA Resolvins and protectins in inflammation resolution. 2011 Chem. Rev. pmid:21766791
Pan JP et al. Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. 2011 Brain Res. pmid:21803345
Imhoff-Kunsch B et al. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. 2011 Pediatrics pmid:21807696
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Jing K et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. 2011 Autophagy pmid:21811093
Roqueta-Rivera M et al. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. 2011 Biol. Reprod. pmid:21653892
Nakamoto K et al. Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. 2011 Eur. J. Pharmacol. pmid:21658380
Martin CR et al. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. 2011 J. Pediatr. pmid:21658712
Vargas ML et al. Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. 2011 Metab. Clin. Exp. pmid:21640360
German JB Dietary lipids from an evolutionary perspective: sources, structures and functions. 2011 Matern Child Nutr pmid:21366863
Glaser C et al. Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. 2011 Matern Child Nutr pmid:21366865
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Kuipers RS et al. Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21903369
Mayurasakorn K et al. Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. 2011 Curr Opin Clin Nutr Metab Care pmid:21178607
Tyburczy C et al. Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21885269
Fedorova-Dahms I et al. Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. 2011 Food Chem. Toxicol. pmid:21914458
Lebbadi M et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. 2011 J. Alzheimers Dis. pmid:21914946
Farias SE et al. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. 2011 J Trauma pmid:21427623
Makhoul Z et al. Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. 2011 Eur J Clin Nutr pmid:21427737
Abelsohn A et al. Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years. 2011 Can Fam Physician pmid:21322285
da Costa KA et al. Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. 2011 Am. J. Clin. Nutr. pmid:21411618
Freeman MP and Rapaport MH Omega-3 fatty acids and depression: from cellular mechanisms to clinical care. 2011 J Clin Psychiatry pmid:21382308
Wagner K et al. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. 2011 Prostaglandins Other Lipid Mediat. pmid:21854866
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Song KS et al. Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. 2011 Pancreatology pmid:22213040
Nochera CL et al. Consumption of DHA + EPA by low-income women during pregnancy and lactation. 2011 Nutr Clin Pract pmid:21724916
Meldrum SJ et al. The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. 2011 Contemp Clin Trials pmid:21718804
D'Alessandro A et al. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. 2011 J Proteomics pmid:21723426
Maki KC et al. Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. 2011 J. Cardiovasc. Pharmacol. pmid:21297494
Courville AB et al. Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. 2011 Br. J. Nutr. pmid:21521543
Bradbury J Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. 2011 Nutrients pmid:22254110
Ferreira M et al. Effect of the nutritional status of semi-continuous microalgal cultures on the productivity and biochemical composition of Brachionus plicatilis. 2011 Mar. Biotechnol. pmid:21487686
Smithers LG et al. Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. 2011 Am. J. Clin. Nutr. pmid:21490140
Yalçın S et al. Effect of maternal corticosterone on utilisation of residual yolk sac fatty acids by developing broiler embryo. 2011 Br. Poult. Sci. pmid:21491250
Morris MC and Tangney CC A potential design flaw of randomized trials of vitamin supplements. 2011 JAMA pmid:21467288
Shoji H et al. Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. 2011 Acta Paediatr. pmid:21366690
Madsen T et al. Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and in subjects without kidney disease: a comparative study. 2011 J Ren Nutr pmid:20833075
Egert S and Stehle P Impact of n-3 fatty acids on endothelial function: results from human interventions studies. 2011 Curr Opin Clin Nutr Metab Care pmid:21252652
Recchiuti A et al. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. 2011 FASEB J. pmid:20956612
Basselin M et al. Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. 2011 J. Cereb. Blood Flow Metab. pmid:20664612
Poudyal H et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. 2011 Prog. Lipid Res. pmid:21762726
Weise C et al. Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. 2011 Pediatr Allergy Immunol pmid:21294775
Meijerink J et al. The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation. 2011 Br. J. Nutr. pmid:21294934
Drover JR et al. Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. 2011 Early Hum. Dev. pmid:21295417
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Klein CM and Jenkins TC Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. 2011 J. Dairy Sci. pmid:21854940
Wang F et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. 2011 Curr. Mol. Med. pmid:21663587
Lima-Garcia JF et al. The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. 2011 Br. J. Pharmacol. pmid:21418187
Xu ZZ and Ji RR Resolvins are potent analgesics for arthritic pain. 2011 Br. J. Pharmacol. pmid:21418190
Nobili V et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. 2011 Arch. Dis. Child. pmid:21233083
Aarsetoey H et al. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. 2011 Lipids pmid:21234696
Salm P et al. Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and arachidonic acid in plasma by high-performance liquid chromatography-tandem mass spectrometry. 2011 Biomed. Chromatogr. pmid:20737653
Ozsoy O et al. The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. 2011 Neurotox Res pmid:21234736
McNamara RK Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? 2011 Schizophr. Res. pmid:21276713
Taoka Y et al. Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304. 2011 J. Biosci. Bioeng. pmid:21216665
Majkova Z et al. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. 2011 Toxicol. Appl. Pharmacol. pmid:21130106
Patterson RE et al. Marine fatty acid intake is associated with breast cancer prognosis. 2011 J. Nutr. pmid:21178081
Stein AD et al. Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. 2011 J. Nutr. pmid:21178082
Furuhjelm C et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. 2011 Pediatr Allergy Immunol pmid:21332799
Sriram K Confusion between gamma-linolenic acid and gamma-linoleic acid. 2011 Crit. Care Med. pmid:22094528
Scott SD et al. Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. 2011 Enzyme Microb. Technol. pmid:22112910
Karlstetter M et al. Microglia in the healthy and degenerating retina: insights from novel mouse models. 2010 Sep-Oct Immunobiology pmid:20573418