DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Croasdell A et al. Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. 2016 J. Immunol. pmid:26843331
Abdulnour RE et al. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. 2016 Mucosal Immunol pmid:26647716
López-Luna P et al. Fate of orally administered radioactive fatty acids in the late-pregnant rat. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26714850
Visentin S et al. Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. 2016 Early Hum. Dev. pmid:27391868
Wang ZQ et al. Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. 2016 J. Cardiovasc. Pharmacol. pmid:26657886
Viola JR et al. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. 2016 Circ. Res. pmid:27531933
Zhang MJ et al. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. 2016 Circulation pmid:27507404
Georgieva R et al. Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. 2016 Langmuir pmid:26794691
Inoue Y et al. Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. 2016 Crit. Care Med. pmid:26509319
Lu Y et al. Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. 2016 Biosens Bioelectron pmid:26710343
Suzuki-Kemuriyama N et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. 2016 PLoS ONE pmid:27333187
Kim SM et al. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. 2016 EBioMedicine pmid:27322464
Gold DR et al. Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. 2016 Contemp Clin Trials pmid:26784651
Bassuk SS et al. Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). 2016 Contemp Clin Trials pmid:26767629
Wong BH et al. Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. 2016 J. Biol. Chem. pmid:27008858
Gao J et al. Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. 2016 Int. J. Dev. Neurosci. pmid:26639559
Dagorn F et al. Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. 2016 Mar Drugs pmid:27231919
Seeger DR and Murphy EJ Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. 2016 Lipids pmid:26797754
Tran DQ et al. Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. 2016 Mol. Cell. Endocrinol. pmid:26923440
Bernhard W et al. Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. 2016 Eur J Nutr pmid:26363610
Moeinzadeh F et al. Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. 2016 Iran J Kidney Dis pmid:27903997
Zhao Z et al. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. 2016 PLoS ONE pmid:27880795
Heskey CE et al. Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. 2016 Am. J. Clin. Nutr. pmid:26912497
Mason RP et al. Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. 2016 Biochim. Biophys. Acta pmid:27718370
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385
Revuelta M et al. Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. 2016 Brain Pathol. pmid:25990815
Kuda O et al. Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. 2016 Diabetes pmid:27313314
Kim KH et al. Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. 2016 Int J Chron Obstruct Pulmon Dis pmid:27313451
Zhao YL et al. Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis. 2016 Chin. Med. J. pmid:27098797
Barden A et al. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. 2016 Nutrients pmid:27007392
Gharekhani A et al. Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. 2016 Iran J Kidney Dis pmid:27721230
Shomonov-Wagner L et al. Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. 2015 Lipids Health Dis pmid:25889505
Lehmann C et al. Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. 2015 FASEB J. pmid:26289316
Hsiao HM et al. Resolvin D1 Reduces Emphysema and Chronic Inflammation. 2015 Am. J. Pathol. pmid:26468975
Maekawa T et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. 2015 Nat Commun pmid:26374165
Taylan A et al. S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. 2015 J. Korean Med. Sci. pmid:26339162
Herrera BS et al. LXA4 actions direct fibroblast function and wound closure. 2015 Biochem. Biophys. Res. Commun. pmid:26188508
Fiala M et al. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. 2015 FASEB J. pmid:25805829
Qin Y et al. Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. 2015 PLoS ONE pmid:26226139
Orr SK et al. Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25770181
Guichardant M et al. Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. 2015 Biochim. Biophys. Acta pmid:25263947
Rossi S et al. Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages. 2015 Mediators Inflamm. pmid:25684860
Cox R et al. Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25647402
Pierdomenico AM et al. MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. 2015 J. Biol. Chem. pmid:25505240
Saito H et al. Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. 2015 J Oleo Sci pmid:26028326
Gavzan H et al. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. 2015 Naunyn Schmiedebergs Arch. Pharmacol. pmid:26018398
Chiang N et al. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. 2015 J. Exp. Med. pmid:26195725
Marinho GS et al. Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. 2015 Mar Drugs pmid:26184241
Koh AS et al. The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. 2015 Eur J Prev Cardiol pmid:24343844
Wang X et al. Resolution of inflammation is altered in Alzheimer's disease. 2015 Alzheimers Dement pmid:24530025
Calandria JM et al. The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. 2015 Cell. Mol. Neurobiol. pmid:26047923
Calandria JM et al. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. 2015 Cell Death Differ. pmid:25633199
Suo R et al. Generation of Tetracosahexaenoic Acid in Benthic Marine Organisms. 2015 J Oleo Sci pmid:26136172
Kanan Y et al. Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. 2015 Cell. Mol. Neurobiol. pmid:25212825
Orban T et al. Serum levels of lipid metabolites in age-related macular degeneration. 2015 FASEB J. pmid:26187344
Serhan CN et al. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. 2015 Biochim. Biophys. Acta pmid:25139562
Wang CW et al. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. 2015 Infect. Immun. pmid:26667839
Park CK Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. 2015 Mediators Inflamm. pmid:26617436
Nordgren TM et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. 2015 Transl Res pmid:25655838
Kotani K et al. Enzymatic preparation of human milk fat substitutes and their oxidation stability. 2015 J Oleo Sci pmid:25757431
Hashim RB et al. Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. 2015 J Oleo Sci pmid:25748380
Fischer T [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. 2015 Orv Hetil pmid:26548469
Tyurina YY et al. LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. 2015 Free Radic. Res. pmid:25740198
Clouard C et al. Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. 2015 J. Nutr. pmid:25644359
Hsieh JC et al. High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. 2015 J. Pediatr. Gastroenterol. Nutr. pmid:25633498
Wang Y et al. Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. 2015 ACS Appl Mater Interfaces pmid:26539742
Amminger GP et al. Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. 2015 Transl Psychiatry pmid:25585167
Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
Norris SE et al. Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. 2015 Neurobiol. Aging pmid:25676385
Ercan S et al. Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. 2015 Lipids Health Dis pmid:25889219
Talvas J et al. Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. 2015 Clin Nutr pmid:25575640
Sekhon-Loodu S et al. Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. 2015 Int. Immunopharmacol. pmid:25637769
Filipcikova R et al. Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. 2015 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23446211
Wang Y et al. Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles. 2015 Colloids Surf B Biointerfaces pmid:26454543
Li R et al. Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. 2015 J. Food Sci. pmid:26408984
Wendell SG et al. 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. 2015 J. Biol. Chem. pmid:25586183
Maciejewska D et al. Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. 2015 World J. Gastroenterol. pmid:25574105
Berge RK et al. Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. 2015 Lipids Health Dis pmid:26666303
Linhartova P and Sampels S Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. 2015 Lipids Health Dis pmid:26627047
Morin C et al. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. 2015 Arthritis Res. Ther. pmid:26022389
Yoshinaga K et al. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. 2015 J. Nutr. Biochem. pmid:25448607
Cheatham CL and Sheppard KW Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. 2015 Nutrients pmid:26540073
Schwager J et al. ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. 2015 Biomed Res Int pmid:26301248
Harrison JL et al. Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. 2015 Brain Behav. Immun. pmid:25585137
Katakura M et al. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. 2015 PLoS ONE pmid:26485038
Brigandi SA et al. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. 2015 Int J Mol Sci pmid:25946342
Ross AB et al. Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, β-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. 2015 J. Nutr. pmid:26400963
Ossani GP et al. Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. 2015 J Oleo Sci pmid:25948137
Zgorzynska E et al. Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. 2015 Arch. Oral Biol. pmid:25455128
Samokhvalov V et al. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. 2015 Toxicol. Lett. pmid:25300478
Wang Y et al. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. 2015 Shock pmid:26196843
Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
Yang S et al. Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. 2015 J Oleo Sci pmid:25757428
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Wijendran V et al. Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. 2015 Pediatr. Res. pmid:26270575
Cotogni P et al. The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients. 2015 Biomed Res Int pmid:26301250
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Mason JK et al. α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. 2015 Lipids Health Dis pmid:26282560
Esmaeili V et al. Dietary fatty acids affect semen quality: a review. 2015 Andrology pmid:25951427
Kawakami Y et al. Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. 2015 Nutr J pmid:25896182