DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Hashimoto M and Hossain S Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease. 2011 J. Pharmacol. Sci. pmid:21606627
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Kumosani TA and Moselhy SS Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. 2011 Hum Exp Toxicol pmid:20488854
Sullivan JC et al. Modeling the primary oxidation in commercial fish oil preparations. 2011 Lipids pmid:21104333
Madec S et al. CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. 2011 Drug Metab. Dispos. pmid:21778351
Hajjaji N et al. Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. 2011 Lipids pmid:21638063
Kuang YL et al. Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β. 2011 Am. J. Clin. Nutr. pmid:21653803
Kimura F et al. Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. 2011 Lipids pmid:21901511
Lewis MD et al. Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. 2011 J Clin Psychiatry pmid:21903029
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid by a newly isolated microalga, Aurantiochytrium sp. KRS101. 2011 Appl. Biochem. Biotechnol. pmid:21424706
Nelson TL et al. Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. 2011 Eur J Nutr pmid:20706728
Zúñiga J et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. 2011 PLoS ONE pmid:22174823
Glew RH et al. Low docosahexaenoic acid in the diet and milk of American Indian women in New Mexico. 2011 J Am Diet Assoc pmid:21515123
Michaelsen KF et al. Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. 2011 Matern Child Nutr pmid:21366872
Hutchins HL et al. Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. 2011 J. Nutr. Biochem. pmid:20951563
Miyazawa D et al. Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. 2011 Biomed. Res. pmid:21878731
Mazaki-Tovi M et al. Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. 2011 Am. J. Vet. Res. pmid:21879986
Nobili V et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. 2011 Arch. Dis. Child. pmid:21233083
Valera B et al. Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. 2011 Int J Circumpolar Health pmid:21329579
Furuhjelm C et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. 2011 Pediatr Allergy Immunol pmid:21332799
Liu C and Cai WX [Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice]. 2011 Fa Yi Xue Za Zhi pmid:21604451
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Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
Vilaseca MA et al. Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. 2011 Jan-Feb Nutr Hosp pmid:21519739
Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
Mason CM et al. Prescription omega-3s: an overview for nurse practitioners. 2011 Jul-Aug J Cardiovasc Nurs pmid:21666421
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
Trimarco B et al. [The Alpha Omega study]. 2011 Jul-Aug G Ital Cardiol (Rome) pmid:21779112
Gladyshev MI et al. Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. 2011 Mar-Apr Dokl. Biochem. Biophys. pmid:21590375
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
Kilari A et al. Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. 2011 May-Jun Am. J. Hum. Biol. pmid:21484911
Jones JL et al. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. 2011 May-Jun J Clin Lipidol pmid:21600524
Maki KC et al. Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. 2011 Nov-Dec J Clin Lipidol pmid:22108152
Siddiqui RA et al. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. 2011 Nov-Dec Biofactors pmid:22038684
Opperman M et al. Analysis of omega-3 fatty acid content of South African fish oil supplements. 2011 Nov-Dec Cardiovasc J Afr pmid:22159321
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Maki KC et al. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21775113
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Fabelo N et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. 2011 Sep-Oct Mol. Med. pmid:21717034
Shilina NM et al. [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. 2011 Sep-Oct Biomed Khim pmid:22629608
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Lee SM et al. Characterization of lecithin isolated from anchovy (Engraulis japonica) residues deoiled by supercritical carbon dioxide and organic solvent extraction. 2012 J. Food Sci. pmid:22757698
Petrie JR et al. Metabolic engineering plant seeds with fish oil-like levels of DHA. 2012 PLoS ONE pmid:23145108
López-Alarcón M et al. Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. 2012 Nutrition pmid:22079797
Skulas-Ray AC et al. Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. 2012 Ann Behav Med pmid:22865498
Le HD et al. Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038210
Towhidi A and Parks JE Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. 2012 J. Assist. Reprod. Genet. pmid:22869241
Tillman EM et al. Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. 2012 JPEN J Parenter Enteral Nutr pmid:22038211
Fasano E et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. 2012 Biochim. Biophys. Acta pmid:22898250
Tyburczy C et al. Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. 2012 Br. J. Nutr. pmid:22040360
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Betancor MB et al. Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. 2012 Lipids pmid:23086553
Berson EL et al. ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. 2012 Arch. Ophthalmol. pmid:22332205
Beezhold BL and Johnston CS Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. 2012 Nutr J pmid:22333737
Rondanelli M et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. 2012 Nutr Neurosci pmid:22334085
Rockett BD et al. Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. 2012 J. Lipid Res. pmid:22315394
Hjorth E and Freund-Levi Y Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. 2012 Curr Opin Clin Nutr Metab Care pmid:22316559
Bragt MC and Mensink RP Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. 2012 Nutr Metab Cardiovasc Dis pmid:21429719
Contreras GA et al. Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. 2012 J. Dairy Sci. pmid:23040031
Skender B et al. Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. 2012 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23069883
Schmitt D et al. Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. 2012 Food Chem. Toxicol. pmid:22960629
Huang TY et al. A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. 2012 Bioresour. Technol. pmid:22929740
Feng Z et al. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. 2012 Antioxid. Redox Signal. pmid:21905985
Moreno-Indias I et al. The effect of diet and DHA addition on the sensory quality of goat kid meat. 2012 Meat Sci. pmid:21907501
Rupp H et al. Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". 2012 Can. J. Physiol. Pharmacol. pmid:22188440
Peters BS et al. The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. 2012 Clin Ther pmid:22212377
Munro IA and Garg ML Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. 2012 Br. J. Nutr. pmid:22214842
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Basselin M et al. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. 2012 Brain Res. Bull. pmid:22178644
Deike E et al. The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. 2012 J Ren Nutr pmid:22285316
Trépanier MO et al. Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. 2012 Epilepsy Res. pmid:22285511
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Kitson AP et al. Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749739
Johnson M et al. Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. 2012 Atten Defic Hyperact Disord pmid:22753087
Quinn EA and Kuzawa CW A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. 2012 Acta Paediatr. pmid:22759234
Turk HF et al. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. 2012 PLoS ONE pmid:22761867
Hacioglu G et al. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. 2012 Folia Histochem. Cytobiol. pmid:22763967
Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Moallem U and Zachut M Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. 2012 J. Dairy Sci. pmid:22720961
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Oblozinský M et al. New pharmaceutical insights related to the pathways of PUFAs. 2012 Ceska Slov Farm pmid:23251954
Kwak SM et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. 2012 Arch. Intern. Med. pmid:22493407
Liu SH et al. Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. 2012 Brain Res. pmid:22440676
Lorenzetti A et al. Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. 2012 Acta Biomed pmid:23393918
Glover KE et al. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. 2012 J. Dairy Sci. pmid:22612917
Corsetto PA et al. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. 2012 Cell Biochem. Biophys. pmid:22622660
Bell S et al. The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. 2012 Clin. Nephrol. pmid:22595386
Hajjaji N et al. Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. 2012 Cancer Chemother. Pharmacol. pmid:22610354
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. 2012 Br. J. Nutr. pmid:22591907
Njoroge SW et al. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. 2012 J. Lipid Res. pmid:22095831
Wielinga PY et al. Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. 2012 Mol Nutr Food Res pmid:22611002
Calder PC Long-chain fatty acids and inflammation. 2012 Proc Nutr Soc pmid:22369781
Kelley DS and Adkins Y Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. 2012 Proc Nutr Soc pmid:22369859
Yui K et al. Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. 2012 J Clin Psychopharmacol pmid:22370992