DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Carcinoma D002277 18 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Dementia D003704 2 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Brain Neoplasms D001932 15 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Spiekerkoetter U et al. Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. 2004 Muscle Nerve pmid:14694500
Higgins S et al. Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts. 1999 Mutagenesis pmid:10375002
Kuroda Y et al. Desmutagenic and bio-antimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured Chinese hamster V79 cells. 2001 Mutat. Res. pmid:11525914
Danesi F et al. Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases. 2010 Mutat. Res. pmid:20067801
Sasaki YF et al. Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil--docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid--in cultured Chinese hamster cells. 1994 Mutat. Res. pmid:7506391
Nagao T et al. One-pot enzymatic synthesis of docosahexaenoic acid-rich triacylglycerols at the sn-1(3) position using by-product from selective hydrolysis of tuna oil. 2011 N Biotechnol pmid:20709631
Weiner MA Cholesterol in foods rich in omega-3 fatty acids. 1986 N. Engl. J. Med. pmid:2943996
Bønaa KH et al. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study. 1990 N. Engl. J. Med. pmid:2137901
Kida Y Eicosanoids in cystic fibrosis. 2004 N. Engl. J. Med. pmid:15128902
Baillie JK and Digard P Influenza--time to target the host? 2013 N. Engl. J. Med. pmid:23841736
Steger B and Colvin HP Eicosanoids in cystic fibrosis. 2004 N. Engl. J. Med. pmid:15131835
Lee TH et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. 1985 N. Engl. J. Med. pmid:2985986
Kromhout D et al. n-3 fatty acids and cardiovascular events after myocardial infarction. 2010 N. Engl. J. Med. pmid:20929341
Guallar E et al. Mercury, fish oils, and the risk of myocardial infarction. 2002 N. Engl. J. Med. pmid:12456850
Shahar E et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. 1994 N. Engl. J. Med. pmid:8015569
Freedman SD et al. Association of cystic fibrosis with abnormalities in fatty acid metabolism. 2004 N. Engl. J. Med. pmid:14762183
Strandvik B Fatty acid metabolism in cystic fibrosis. 2004 N. Engl. J. Med. pmid:14762189
Cardiovascular effects of n-3 fatty acids. 1988 N. Engl. J. Med. pmid:2841599
Bertrandt J et al. Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. 2004 Nahrung pmid:15146965
Voldrich J et al. Changes of fatty acid composition during the processing of fish. 1991 Nahrung pmid:1838576
Maekawa T et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. 2015 Nat Commun pmid:26374165
Xue Z et al. Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. 2013 Nat. Biotechnol. pmid:23873085
Green AG From alpha to omega-producing essential fatty acids in plants. 2004 Nat. Biotechnol. pmid:15175687
Groeger AL et al. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. 2010 Nat. Chem. Biol. pmid:20436486
Sommer C and Birklein F Fighting off pain with resolvins. 2010 Nat. Med. pmid:20448572
Oh DY et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. 2014 Nat. Med. pmid:24997608
White PJ et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. 2014 Nat. Med. pmid:24813250
Xu ZZ et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 2010 Nat. Med. pmid:20383154
Hirasawa A et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. 2005 Nat. Med. pmid:15619630
Luan HM et al. Antioxidant activities and antioxidative components in the surf clam, Mactra veneriformis. 2011 Nat. Prod. Res. pmid:21756123
Wood H An X-orphan. 2001 Nat. Rev. Neurosci. pmid:11252996
Betsholtz C Physiology: Double function at the blood-brain barrier. 2014 Nature pmid:24828036
Nguyen LN et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. 2014 Nature pmid:24828044
Itoh Y et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. 2003 Nature pmid:12629551
Serhan CN Pro-resolving lipid mediators are leads for resolution physiology. 2014 Nature pmid:24899309
Swinbanks D Fish-oil miracle additive brings benefits to some. 1993 Nature pmid:8321302
Chiang N et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. 2012 Nature pmid:22538616
Schwab JM et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. 2007 Nature pmid:17568749
Spite M et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. 2009 Nature pmid:19865173
Turner N et al. Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism. 2003 Naturwissenschaften pmid:14610651
Gavzan H et al. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. 2015 Naunyn Schmiedebergs Arch. Pharmacol. pmid:26018398
Reithmann C et al. Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. 1996 Naunyn Schmiedebergs Arch. Pharmacol. pmid:8857587
Itoh T and Yamamoto K Peroxisome proliferator activated receptor gamma and oxidized docosahexaenoic acids as new class of ligand. 2008 Naunyn Schmiedebergs Arch. Pharmacol. pmid:18193404
Dhein S et al. Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids. 2005 Naunyn Schmiedebergs Arch. Pharmacol. pmid:15900514
Korstanje MJ et al. [Fish oil; from food to medicine?]. 1991 Ned Tijdschr Geneeskd pmid:1828538
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Mitmesser SH and Jensen CL Roles of long-chain polyunsaturated fatty acids in the term infant: developmental benefits. 2007 Jul-Aug Neonatal Netw pmid:17710956
Lapillonne A et al. Postnatal docosahexaenoic acid deficiency is an inevitable consequence of current recommendations and practice in preterm infants. 2010 Neonatology pmid:21051909
Berman DR et al. Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. 2013 Neonatology pmid:23817197
Hu Y et al. Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. 2010 Neoplasia pmid:20927321
Huang X et al. Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. 2014 Nephrol. Dial. Transplant. pmid:23229929
Saifullah A et al. Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study. 2007 Nephrol. Dial. Transplant. pmid:17623719
Ferraro PM et al. Combined treatment with renin-angiotensin system blockers and polyunsaturated fatty acids in proteinuric IgA nephropathy: a randomized controlled trial. 2009 Nephrol. Dial. Transplant. pmid:18685141
Chin HJ et al. Omacor, n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals. 2010 Nephrol. Dial. Transplant. pmid:20042400
Cheng IK et al. The effect of fish-oil dietary supplement on the progression of mesangial IgA glomerulonephritis. 1990 Nephrol. Dial. Transplant. pmid:2113220
van Acker BA et al. The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients. 1987 Nephrol. Dial. Transplant. pmid:2831474
Beavers KM et al. Omega-3 fatty acid supplementation and total homocysteine levels in end-stage renal disease patients. 2008 Nephrology (Carlton) pmid:18331436
Rylance PB et al. Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients. 1986 Nephron pmid:3724927
Bazan NG et al. Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. 2013 Nestle Nutr Inst Workshop Ser pmid:24107502
Scholtz SA et al. Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. 2013 Nestle Nutr Inst Workshop Ser pmid:24107504
Turck D Later effects of breastfeeding practice: the evidence. 2007 Nestle Nutr Workshop Ser Pediatr Program pmid:17664895
Michaelsen KF et al. Whole cow's milk: why, what and when? 2007 Nestle Nutr Workshop Ser Pediatr Program pmid:17664906
Makrides M et al. Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. 2010 Nestle Nutr Workshop Ser Pediatr Program pmid:20139678
Vasickova L et al. Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children. 2011 Neuro Endocrinol. Lett. pmid:22101886
Mincke E et al. Lower omega-3 polyunsaturated fatty acids and lower docosahexaenoic acid in men with pedophilia. 2006 Neuro Endocrinol. Lett. pmid:17187003
Maes M et al. Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. 2007 Neuro Endocrinol. Lett. pmid:18063921
Mraz J et al. Culture of common carp (Cyprinus carpio) with defined flesh quality for prevention of cardiovascular diseases using finishing feeding strategy. 2012 Neuro Endocrinol. Lett. pmid:23183512
Sliwinski S et al. Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism? 2006 Neuro Endocrinol. Lett. pmid:16891996
Hacioglu G et al. Beneficial effects of docosahexaenoic acid on active avoidance performance in 1K-1C hypertensive rats. 2007 Neurobiol Learn Mem pmid:16979916
Norris SE et al. Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. 2015 Neurobiol. Aging pmid:25676385
Favrelère S et al. Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. 2000 Sep-Oct Neurobiol. Aging pmid:11016534
Stough C et al. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. 2012 Neurobiol. Aging pmid:21531481
Robson LG et al. Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. 2010 Neurobiol. Aging pmid:18620782
Wang DC et al. Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer's disease. 2012 Neurobiol. Aging pmid:20980076
Walhovd KB et al. Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. 2014 Neurobiol. Aging pmid:24332985
Favrelière S et al. DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. 2003 Mar-Apr Neurobiol. Aging pmid:12498957
Marin R et al. Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases. 2017 Neurobiol. Aging pmid:27768960
Mahmoudi S et al. Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid. 2009 Neurobiol. Dis. pmid:19635563
De Felice C et al. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. 2014 Neurobiol. Dis. pmid:24769161
Hooijmans CR et al. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). 2007 Neurobiol. Dis. pmid:17720508
Hooijmans CR et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. 2009 Neurobiol. Dis. pmid:19130883
Eady TN et al. Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. 2014 Neurobiol. Dis. pmid:24063996
Oksman M et al. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. 2006 Neurobiol. Dis. pmid:16765602
Ouellet M et al. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. 2009 Neurochem. Int. pmid:19442696
Ozsoy O et al. The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. 2011 Neurochem. Int. pmid:21736911
Cieslik M et al. Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. 2013 Neurochem. Int. pmid:23439385
Julien C et al. Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. 2006 Neurochem. Int. pmid:16442670
Grintal B et al. Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: evidence for a signalling role of docosahexaenoic acid. 2009 Neurochem. Int. pmid:19428799
Boudrault C et al. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. 2010 Neurochem. Int. pmid:20064570
Rosenberger TA et al. Rat brain docosahexaenoic acid metabolism is not altered by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. 2010 Neurochem. Int. pmid:20026368
Mathieu G et al. DHA enhances the noradrenaline release by SH-SY5Y cells. 2010 Neurochem. Int. pmid:19770016
Jones CR et al. Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. 1997 Neurochem. Res. pmid:9178948
Ikemoto A et al. Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. 1997 Neurochem. Res. pmid:9178949
Halapin NA and Bazan NG NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling. 2010 Neurochem. Res. pmid:21136150
Lee HJ et al. Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. 2005 Neurochem. Res. pmid:16176072
Alvarez-Nölting R et al. Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. 2012 Neurochem. Res. pmid:21909958
Brown J et al. Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). 2009 Neurochem. Res. pmid:18592376
Terrian DM et al. Glutamate is the endogenous amino acid selectively released by rat hippocampal mossy fiber synaptosomes concomitantly with prodynorphin-derived peptides. 1990 Neurochem. Res. pmid:1970130
Petroni A et al. Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. 1994 Neurochem. Res. pmid:7824073
Schonfeld E et al. Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. 2007 Neurochem. Res. pmid:17551831