| MeSH term | MeSH ID | Detail |
|---|---|---|
| Premature Birth | D047928 | 6 associated lipids |
| Malnutrition | D044342 | 6 associated lipids |
| Optic Nerve Diseases | D009901 | 6 associated lipids |
| Peripheral Nerve Injuries | D059348 | 6 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Intermittent Claudication | D007383 | 6 associated lipids |
| Retinitis Pigmentosa | D012174 | 6 associated lipids |
| Keratitis | D007634 | 7 associated lipids |
| Dyslipidemias | D050171 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu T et al. | Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. | 2002 | Lipids | pmid:12371750 |
| Saito M and Kubo K | An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats. | 2002 | Ann. Nutr. Metab. | pmid:12378040 |
| Quan LG and Cha JK | Preparation of isoprostanes and neuroprostanes. | 2002 | J. Am. Chem. Soc. | pmid:12381179 |
| Ye D et al. | Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12388664 |
| Rodriguez de Turco EB et al. | Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. | 2002 | J. Neurochem. | pmid:12390513 |
| Woodman RJ et al. | Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. | 2002 | Am. J. Clin. Nutr. | pmid:12399272 |
| Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
| Glew RH et al. | The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401435 |
| Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
| Nordøy A | Statins and omega-3 fatty acids in the treatment of dyslipidemia and coronary heart disease. | 2002 | Minerva Med. | pmid:12410168 |
| van Wezel-Meijler G et al. | Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. | 2002 | Acta Paediatr. | pmid:12412870 |
| Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
| Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
| Bowen RA and Clandinin MT | Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. | 2002 | J. Neurochem. | pmid:12421348 |
| Abhyankar B | Further reduction in mortality following myocardial infarction. | 2002 | Hosp Med | pmid:12422496 |
| Montine TJ et al. | Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. | 2002 | J. Neurochem. | pmid:12423256 |
| Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
| Meireles LA et al. | Increase of the yields of eicosapentaenoic and docosahexaenoic acids by the microalga Pavlova lutheri following random mutagenesis. | 2003 | Biotechnol. Bioeng. | pmid:12432580 |
| Wang L and Muttucumaru S | Separation of biosynthetic polyunsaturated fatty acid (PUFA) with supercritical fluid. | 2002 | Biotechnol Annu Rev | pmid:12436919 |
| Kearns SD and Haag M | The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445489 |
| Andersson A et al. | Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12450886 |
| Passi S et al. | Fatty acid composition and antioxidant levels in muscle tissue of different Mediterranean marine species of fish and shellfish. | 2002 | J. Agric. Food Chem. | pmid:12452651 |
| Pratt VC et al. | Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. | 2002 | Br. J. Cancer | pmid:12454764 |
| Wang YW et al. | Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. | 2002 | Poult. Sci. | pmid:12455601 |
| Guallar E et al. | Mercury, fish oils, and the risk of myocardial infarction. | 2002 | N. Engl. J. Med. | pmid:12456850 |
| Bourre JM and Dumont O | The administration of pig brain phospholipids versus soybean phospholipids in the diet during the period of brain development in the rat results in greater increments of brain docosahexaenoic acid. | 2002 | Neurosci. Lett. | pmid:12459515 |
| Furuya H et al. | Effect of ethanol and docosahexaenoic acid on nerve growth factor-induced neurite formation and neuron specific growth-associated protein gene expression in PC12 cells. | 2002 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:12462067 |
| Diep QN et al. | PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation. | 2002 | Hypertension | pmid:12468571 |
| Seebungkert B and Lynch JW | Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. | 2002 | Eur. J. Neurosci. | pmid:12473076 |
| Igarashi T et al. | Determination of docosahexaenoic acid and n-3 fatty acids in refined fish oils by 1H-NMR spectroscopy: IUPAC interlaboratory study. | 2002 Nov-Dec | J AOAC Int | pmid:12477198 |
| Woodman RJ et al. | Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. | 2003 | Atherosclerosis | pmid:12482554 |
| Amiano P et al. | Very-long-chain omega-3 fatty acids as markers for habitual fish intake in Spain. | 2002 | IARC Sci. Publ. | pmid:12484164 |
| Baker SD et al. | Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. | 2002 | J. Natl. Cancer Inst. | pmid:12488482 |
| Hashimoto M et al. | [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491779 |
| Catalan J et al. | Cognitive deficits in docosahexaenoic acid-deficient rats. | 2002 | Behav. Neurosci. | pmid:12492301 |
| Siddiqui RA et al. | Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. | 2003 | Biochem. J. | pmid:12492401 |
| Yep YL et al. | Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. | 2002 | Asia Pac J Clin Nutr | pmid:12495260 |
| Briscoe CP et al. | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. | 2003 | J. Biol. Chem. | pmid:12496284 |
| Cerbone AM et al. | [EPA and DHA ethyl esters: potential mechanisms of antischemic action]. | 1999 | Cardiologia | pmid:12497815 |
| Favrelière S et al. | DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. | 2003 Mar-Apr | Neurobiol. Aging | pmid:12498957 |
| Francois CA et al. | Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. | 2003 | Am. J. Clin. Nutr. | pmid:12499346 |
| Woodman RJ et al. | Docosahexaenoic acid but not eicosapentaenoic acid increases LDL particle size in treated hypertensive type 2 diabetic patients. | 2003 | Diabetes Care | pmid:12502701 |
| Kramer JA et al. | Transcription profiling in rat liver in response to dietary docosahexaenoic acid implicates stearoyl-coenzyme a desaturase as a nutritional target for lipid lowering. | 2003 | J. Nutr. | pmid:12514267 |
| Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
| Rousseau D et al. | Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12521943 |
| Wang Y et al. | Docosahexaenoic acid inhibits cytokine-induced expression of P-selectin and neutrophil adhesion to endothelial cells. | 2003 | Eur. J. Pharmacol. | pmid:12524156 |
| De Swaaf ME et al. | High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. | 2003 | Biotechnol. Bioeng. | pmid:12529880 |
| Park Y and Harris W | EPA, but not DHA, decreases mean platelet volume in normal subjects. | 2002 | Lipids | pmid:12530552 |
| Brenner RR | Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538079 |
| Qiu X | Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538082 |