| MeSH term | MeSH ID | Detail |
|---|---|---|
| Malnutrition | D044342 | 6 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Optic Nerve Diseases | D009901 | 6 associated lipids |
| Peripheral Nerve Injuries | D059348 | 6 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Intermittent Claudication | D007383 | 6 associated lipids |
| Retinitis Pigmentosa | D012174 | 6 associated lipids |
| Hepatitis C | D006526 | 7 associated lipids |
| Keratitis | D007634 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Minami M and Noguchi M | Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. | 1996 Sep-Oct | Oncology | pmid:8784475 |
| Palozza P et al. | n-3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation. | 1996 | Am. J. Clin. Nutr. | pmid:8780337 |
| Lecomte M et al. | Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. | 1996 | J. Neurochem. | pmid:8780049 |
| Rotstein NP et al. | Docosahexaenoic acid is required for the survival of rat retinal photoreceptors in vitro. | 1996 | J. Neurochem. | pmid:8780010 |
| Maccoll AJ et al. | Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils. | 1996 | Br. J. Nutr. | pmid:8774223 |
| Weisinger HS et al. | Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. | 1996 | Ann. Nutr. Metab. | pmid:8773733 |
| Boswell K et al. | Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. | 1996 | Food Chem. Toxicol. | pmid:8761351 |
| Yamada Y et al. | Effect of eicosapentaenoic acid and docosahexaenoic acid on diabetic osteopenia. | 1995 | Diabetes Res. Clin. Pract. | pmid:8745204 |
| Degrace P et al. | Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. | 1996 | Lipids | pmid:8743053 |
| Sasaki H et al. | [Immunosuppressive effect of intravenously injected docosahexaenoic acid on single lung allotransplantation in the rat]. | 1996 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8741552 |
| McLennan P et al. | The cardiovascular protective role of docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8741170 |
| Boehm G et al. | Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids. | 1996 | Eur. J. Pediatr. | pmid:8741041 |
| Cerolini S et al. | Preferential mobilisation of docosahexaenoic acid from adipose tissue triacylglycerol of the chick embryo. | 1996 | Biochem. Soc. Trans. | pmid:8736823 |
| Green P and Yavin E | Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. | 1996 | Lipids | pmid:8729125 |
| Connor WE et al. | Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. | 1996 | Lipids | pmid:8729116 |
| Gibson RA et al. | Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. | 1996 | Lipids | pmid:8729115 |
| Martinez M | Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. | 1996 | Lipids | pmid:8729110 |
| Croset M et al. | In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. | 1996 | Lipids | pmid:8729104 |
| De Caterina R and Libby P | Control of endothelial leukocyte adhesion molecules by fatty acids. | 1996 | Lipids | pmid:8729095 |
| Carlson SE et al. | Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. | 1996 | Pediatr. Res. | pmid:8726246 |
| Hammes HP et al. | Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids. | 1996 | Diabetologia | pmid:8721768 |
| Chen Y et al. | Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. | 1996 | J. Biol. Chem. | pmid:8702792 |
| Lim BO et al. | Effects of n-3 polyunsaturated fatty acids and lectins on immunoglobulin production by spleen lymphocytes of Sprague-Dawley rats. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8695902 |
| Innis SM and Hansen JW | Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. | 1996 | Am. J. Clin. Nutr. | pmid:8694015 |
| Yamane M et al. | Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma. | 1996 | J Chromatogr A | pmid:8680600 |
| Tamura M and Suzuki H | Effect of docosahexaenoic acid and sardine oil diets on the ultrastructure of hepatocytes in adult mice. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:8676220 |
| Lagarde M | [Biosynthesis and functions of eicosanoids. Recent data]. | 1995 | C. R. Seances Soc. Biol. Fil. | pmid:8673630 |
| Rotstein NP et al. | Active synthesis of C24:5, n-3 fatty acid in retina. | 1996 | Biochem. J. | pmid:8670163 |
| Innis SM et al. | Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age. | 1996 | Am. J. Clin. Nutr. | pmid:8669412 |
| Marzo I et al. | Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. | 1996 | Biochim. Biophys. Acta | pmid:8664338 |
| Luthria DL et al. | Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid. | 1996 | J. Biol. Chem. | pmid:8663162 |
| Moore SA et al. | Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. | 1995 | J. Lipid Res. | pmid:8656081 |
| Beijers RJ and Schaafsma A | Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation. | 1996 | Early Hum. Dev. | pmid:8654314 |
| Balestrieri GP et al. | Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. | 1996 | Recenti Prog Med | pmid:8650428 |
| Jørgensen MH et al. | Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. | 1996 | Lipids | pmid:8649242 |
| Werkman SH and Carlson SE | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. | 1996 | Lipids | pmid:8649241 |
| Carlson SE and Werkman SH | A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. | 1996 | Lipids | pmid:8649239 |
| Weisinger HS et al. | The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. | 1996 | Lipids | pmid:8649236 |
| Makrides M et al. | Is dietary docosahexaenoic acid essential for term infants? | 1996 | Lipids | pmid:8649228 |
| Prisco D et al. | Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. | 1996 | Am. J. Clin. Nutr. | pmid:8644688 |
| Khair-El-Din T et al. | Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. | 1996 | J. Exp. Med. | pmid:8642266 |
| Engler MB and Engler MM | Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. | 1996 | Gerontology | pmid:8641598 |
| Serhiienko OO | [The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)]. | 1995 May-Jun | Lik. Sprava | pmid:8630815 |
| Pageaux JF et al. | Biogenesis and metabolic fate of docosahexaenoic and arachidonic acids in rat uterine stromal cells in culture. | 1996 | Arch. Biochem. Biophys. | pmid:8615684 |
| Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
| Shashoua VE and Hesse GW | N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. | 1996 | Life Sci. | pmid:8614292 |
| Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. | 1996 | J. Clin. Invest. | pmid:8613538 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. | 1996 | Scand. J. Immunol. | pmid:8602457 |
| Hughes DA et al. | (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. | 1996 | J. Nutr. | pmid:8598544 |
| Christensen JH et al. | Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. | 1996 | BMJ | pmid:8597736 |