| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Choline Deficiency | D002796 | 16 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Deficiency Diseases | D003677 | 12 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miyashima A et al. | DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141691 |
| Chien KL et al. | A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. | 2013 | BMC Med Res Methodol | pmid:23414574 |
| Hiratsuka S et al. | Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. | 2013 | J. Nutr. Sci. Vitaminol. | pmid:23727644 |
| Ramkumar HL et al. | Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. | 2013 | J. Nutr. | pmid:23677863 |
| Nagai T et al. | Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. | 2013 | J Oleo Sci | pmid:24292353 |
| Dalal JJ et al. | Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. | 2012 Sep-Oct | Indian Heart J | pmid:23102390 |
| Baum SJ | EPA and DHA: distinct yet essential n-3 fatty acids. | 2012 Sep-Oct | J Clin Lipidol | pmid:23009786 |
| Castro González MI et al. | [Renal patient's diet: Can fish be included?]. | 2012 Sep-Oct | Nutr Hosp | pmid:23478696 |
| Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Ma L et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. | 2012 Nov-Dec | Nutrition | pmid:23044165 |
| Sanz ParÃs A et al. | [Proposed profile of omega 3 fatty acids in enteral nutrition]. | 2012 Nov-Dec | Nutr Hosp | pmid:23588426 |
| Brown WV | From the editor. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312044 |
| Derosa G et al. | Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312051 |
| Davidson MH et al. | A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312053 |
| Abad S and Turon X | Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. | 2012 May-Jun | Biotechnol. Adv. | pmid:22261015 |
| An WS et al. | Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22071008 |
| Jacobson TA et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. | 2012 Jan-Feb | J Clin Lipidol | pmid:22264569 |
| Widgerow AD | Cellular resolution of inflammation--catabasis. | 2012 Jan-Feb | Wound Repair Regen | pmid:22276585 |
| Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Helmersson-Karlqvist J et al. | Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047909 |
| Kuipers RS et al. | Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22093549 |
| Sørensen IM et al. | Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. | 2012 | Diabetes Metab. Res. Rev. | pmid:22396195 |
| Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
| Jayashankar S et al. | Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. | 2012 | Environ. Toxicol. Pharmacol. | pmid:22056564 |
| Noreen EE and Brandauer J | The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. | 2012 | J Complement Integr Med | pmid:23104856 |
| Kautharapu KB and Jarboe LR | Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). | 2012 | J. Bacteriol. | pmid:23105048 |
| Li N et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22020559 |
| Samaee SM and Estévez A | Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. | 2012 | J Exp Zool A Ecol Genet Physiol | pmid:22021057 |
| Yang ZH et al. | Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. | 2012 | Lipids Health Dis | pmid:22846384 |
| Jackson PA et al. | No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. | 2012 | Br. J. Nutr. | pmid:21864417 |
| Harden CJ et al. | Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. | 2012 | Br. J. Nutr. | pmid:22313587 |
| Komatsuzaki N and Shima J | Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22313752 |
| Tan Z et al. | Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. | 2012 | Food Chem | pmid:23442661 |
| O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
| Cazzola R et al. | Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. | 2012 | Exp. Gerontol. | pmid:23000875 |
| Chiu CY et al. | Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. | 2012 | Inflamm. Res. | pmid:22618200 |
| Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
| Zicker SC et al. | Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. | 2012 | J. Am. Vet. Med. Assoc. | pmid:22916855 |
| Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
| Stein AD et al. | Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. | 2012 | J. Nutr. | pmid:22739364 |
| Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
| Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
| Holly LT et al. | Dietary therapy to promote neuroprotection in chronic spinal cord injury. | 2012 | J Neurosurg Spine | pmid:22735048 |
| Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
| Liao Z et al. | Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. | 2012 | Respir. Res. | pmid:23199346 |
| Bianchini F et al. | 22Â :Â 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. | 2012 | Br. J. Nutr. | pmid:22390897 |
| Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
| Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |