| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Choline Deficiency | D002796 | 16 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Deficiency Diseases | D003677 | 12 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishida T et al. | Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375839 |
| Lamaziere A et al. | Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21109411 |
| Sayanova O and Napier JA | Transgenic oilseed crops as an alternative to fish oils. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21596549 |
| Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
| Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
| McNamara RK | Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19515544 |
| von Schacky C | Cardiovascular disease prevention and treatment. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520557 |
| Bazan NG | Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520558 |
| Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
| Shinto L et al. | Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19171471 |
| Luxwolda MF et al. | The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21715149 |
| Le HD et al. | The essentiality of arachidonic acid and docosahexaenoic acid. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540099 |
| Dyerberg J et al. | Bioavailability of marine n-3 fatty acid formulations. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20638827 |
| Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
| Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
| Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
| Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
| Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
| Rapoport SI et al. | Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060754 |
| Mukherjee PK et al. | Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060755 |
| Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
| Koletzko B et al. | Does dietary DHA improve neural function in children? Observations in phenylketonuria. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19615874 |
| Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
| Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Ly LH et al. | Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16221546 |
| He J and Bazan HE | Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20202804 |
| Astarita G and Piomelli D | Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21543199 |
| Fortier M et al. | Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism? | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206489 |
| Raza Shaikh S | Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207118 |
| Kim HY et al. | Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207120 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
| Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
| Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
| Honda KL et al. | Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25921297 |
| Kitson AP et al. | Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749739 |
| Smit EN et al. | Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913225 |
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| Kearns SD and Haag M | The effect of omega-3 fatty acids on Ca-ATPase in rat cerebral cortex. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445489 |
| Lokesh BR and Kinsella JE | Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846090 |
| Matsumoto K et al. | Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8302921 |
| Fenton JI and McCaskey SJ | Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266210 |
| Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| Samman S | The effect of Max Epa on low density lipoprotein metabolism: perspectives from an animal model. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1886911 |
| Cunnane SC et al. | Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22575581 |
| Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
| Kuipers RS et al. | Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22093549 |
| Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |