Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kikugawa K et al. | beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. | 1997 | FEBS Lett. | pmid:9119059 |
Ndiaye J and Hayashi S | Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. | 1996 | Cell Struct. Funct. | pmid:9118236 |
Mandell IB et al. | Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. | 1997 | J. Anim. Sci. | pmid:9110201 |
McKeone BJ et al. | Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. | 1997 | J. Lipid Res. | pmid:9101424 |
Rodriguez de Turco EB et al. | Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. | 1997 | J. Biol. Chem. | pmid:9099692 |
Mohan IK and Das UN | Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089797 |
Bouglé D et al. | Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. | 1996 | Ann. Nutr. Metab. | pmid:9087310 |
Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
Atkinson TG et al. | Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. | 1997 | Lipids | pmid:9076666 |
Kimura S et al. | Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072405 |
Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
Kelso KA et al. | Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. | 1997 | J. Reprod. Fertil. | pmid:9068407 |
Yamane M and Abe A | Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. | 1995 | Neurosci. Lett. | pmid:9064612 |
Infante JP and Huszagh VA | On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. | 1997 | Mol. Cell. Biochem. | pmid:9062899 |
Orth M and Luley C | Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. | 1997 | Eur J Clin Chem Clin Biochem | pmid:9056751 |
Dacremont G and Vincent G | Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. | 1995 | J. Inherit. Metab. Dis. | pmid:9053558 |
Iigo M et al. | Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. | 1997 | Br. J. Cancer | pmid:9043019 |
Wainwright PE et al. | Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. | 1997 | J. Nutr. | pmid:9040564 |
Kresiun VI et al. | [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. | 1996 Mar-Apr | Lik. Sprava | pmid:9035880 |
Delton-Vandenbroucke I et al. | Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9034209 |
Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
Badalamenti S et al. | Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. | 1997 | Hepatology | pmid:9021940 |
Noguchi M et al. | Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. | 1997 | Br. J. Cancer | pmid:9020478 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Tamura M and Suzuki H | Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. | 1996 | Ann. Nutr. Metab. | pmid:9001686 |
Conquer JA and Holub BJ | Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. | 1996 | J. Nutr. | pmid:9001371 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Taugbøl O et al. | An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. | 1996 | Acta Vet. Scand. | pmid:8996873 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Martin DD et al. | The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. | 1996 | Lipids | pmid:8972462 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
Brossard N et al. | Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. | 1996 | Am. J. Physiol. | pmid:8967415 |
Futamura Y | Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. | 1996 | J Toxicol Sci | pmid:8959650 |
Foreman-van Drongelen MM et al. | Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. | 1996 | Br. J. Nutr. | pmid:8958000 |
Garratt JC et al. | Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8957264 |
Ohira T et al. | Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. | 1996 | J. Cancer Res. Clin. Oncol. | pmid:8954167 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Reinboth JJ et al. | Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. | 1996 | Exp. Eye Res. | pmid:8943700 |
Katoku Y et al. | Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. | 1996 | Am. J. Clin. Nutr. | pmid:8942411 |
Suzuki Y et al. | Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. | 1996 | Acta Paediatr Jpn | pmid:8942014 |
Poling JS et al. | Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. | 1996 | Neuropharmacology | pmid:8938727 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
De Craemer D et al. | Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. | 1996 | Lipids | pmid:8934448 |
Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
Agren JJ et al. | Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. | 1996 | Eur J Clin Nutr | pmid:8933125 |
Santos FF et al. | Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. | 1995-1996 | Int Ophthalmol | pmid:8926126 |
Carballeira NM et al. | Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8925444 |
Zerouga M et al. | Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. | 1996 Sep-Oct | Anticancer Res. | pmid:8917399 |