Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Amiano P et al. | Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. | 2014 | Nutr Metab Cardiovasc Dis | pmid:24360762 |
Currais A et al. | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. | 2014 | Aging Cell | pmid:24341874 |
Betsholtz C | Physiology: Double function at the blood-brain barrier. | 2014 | Nature | pmid:24828036 |
Nguyen LN et al. | Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. | 2014 | Nature | pmid:24828044 |
Chua A et al. | Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. | 2014 | Environ. Mol. Mutagen. | pmid:24828973 |
Hong S et al. | Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25273880 |
Ma QL et al. | Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. | 2014 | J. Neurosci. | pmid:24849348 |
Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Torres M et al. | Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. | 2014 | Biochim. Biophys. Acta | pmid:24374316 |
De Felice C et al. | Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. | 2014 | Neurobiol. Dis. | pmid:24769161 |
Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
Cui ZG et al. | Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. | 2014 | Chem. Biol. Interact. | pmid:24661947 |
Adarme-Vega TC et al. | Towards sustainable sources for omega-3 fatty acids production. | 2014 | Curr. Opin. Biotechnol. | pmid:24607804 |
Aronow ME and Chew EY | Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. | 2014 | Curr Opin Ophthalmol | pmid:24614146 |
Murali G et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24332315 |
Walhovd KB et al. | Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. | 2014 | Neurobiol. Aging | pmid:24332985 |
Eto M et al. | A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24333445 |
Hong S et al. | Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. | 2014 | Chem. Biol. | pmid:25200603 |
Chen F et al. | Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. | 2014 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:24072678 |
Eady TN et al. | Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. | 2014 | Neurobiol. Dis. | pmid:24063996 |
Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
Izquierdo MS et al. | Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. | 2013 | Br. J. Nutr. | pmid:23046500 |
Kasuya F et al. | Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. | 2013 | J Enzyme Inhib Med Chem | pmid:22299587 |
Sánchez-MartÃn MJ et al. | Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. | 2013 | Chembiochem | pmid:23447332 |
Pacetti D et al. | Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). | 2013 | J. Agric. Food Chem. | pmid:23531042 |
Kuratko CN et al. | The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. | 2013 | Nutrients | pmid:23877090 |
Vigerust NF et al. | Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. | 2013 | Eur J Nutr | pmid:22923017 |
Marty-Roix R and Lien E | (De-) oiling inflammasomes. | 2013 | Immunity | pmid:23809158 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Zhang L et al. | Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. | 2013 | Bioresour. Technol. | pmid:23751810 |
Janczyk W et al. | Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. | 2013 | BMC Pediatr | pmid:23702094 |
GarcÃa-Sastre A | Lessons from lipids in the fight against influenza. | 2013 | Cell | pmid:23827671 |
Chen HF and Su HM | Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. | 2013 | J. Nutr. Biochem. | pmid:22818715 |
Mortensen K and Tawia S | Sustained breastfeeding. | 2013 | Breastfeed Rev | pmid:23600325 |
Sadli N et al. | Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. | 2013 | Cell. Physiol. Biochem. | pmid:23942088 |
Crawford MA et al. | A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23206328 |
Kim K et al. | A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. | 2013 | Bioresour. Technol. | pmid:23206808 |
Stanley WC et al. | Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. | 2013 | J Cardiovasc Transl Res | pmid:24065618 |