Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Midtbø LK et al. | Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. | 2015 | J. Nutr. Biochem. | pmid:25776459 |
Taylan A et al. | S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. | 2015 | J. Korean Med. Sci. | pmid:26339162 |
Croasdell A et al. | Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26301452 |
de Oliveira JR et al. | AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4. | 2015 | Biomed Res Int | pmid:26075216 |
Qin Y et al. | Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | 2015 | PLoS ONE | pmid:26226139 |
Orr SK et al. | Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25770181 |
Dalli J et al. | Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. | 2015 | FASEB J. | pmid:25713027 |
Rossi S et al. | Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages. | 2015 | Mediators Inflamm. | pmid:25684860 |
Lastrucci C et al. | Molecular and cellular profiles of the resolution phase in a damage-associated molecular pattern (DAMP)-mediated peritonitis model and revelation of leukocyte persistence in peritoneal tissues. | 2015 | FASEB J. | pmid:25609430 |
Cespedes E et al. | Adipose tissue n-3 fatty acids and metabolic syndrome. | 2015 | Eur J Clin Nutr | pmid:25097001 |
Akagi D et al. | Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. | 2015 | FASEB J. | pmid:25777995 |
Calandria JM et al. | The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. | 2015 | Cell. Mol. Neurobiol. | pmid:26047923 |
Dorninger F et al. | Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. | 2015 | Biochim. Biophys. Acta | pmid:25463479 |
Barden AE et al. | Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirin. | 2015 | Am. J. Clin. Nutr. | pmid:26561623 |
Park CK | Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. | 2015 | Mediators Inflamm. | pmid:26617436 |
Askari M et al. | Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. | 2015 | Clin Transl Oncol | pmid:25351172 |
Jones PJ et al. | High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. | 2015 | Atherosclerosis | pmid:25528432 |
Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
Norris SE et al. | Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. | 2015 | Neurobiol. Aging | pmid:25676385 |
Filipcikova R et al. | Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23446211 |
Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
Wendell SG et al. | 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. | 2015 | J. Biol. Chem. | pmid:25586183 |
Chen CT et al. | Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. | 2015 | Sci Rep | pmid:26511533 |
Linhartova P and Sampels S | Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. | 2015 | Lipids Health Dis | pmid:26627047 |
Park HG et al. | The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. | 2015 | FASEB J. | pmid:26065859 |
Lim JY et al. | Biological Roles of Resolvins and Related Substances in the Resolution of Pain. | 2015 | Biomed Res Int | pmid:26339646 |
Schwager J et al. | ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. | 2015 | Biomed Res Int | pmid:26301248 |
Katakura M et al. | Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. | 2015 | PLoS ONE | pmid:26485038 |
Chew EY et al. | Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. | 2015 | JAMA | pmid:26305649 |
Ross AB et al. | Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, β-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. | 2015 | J. Nutr. | pmid:26400963 |
Zgorzynska E et al. | Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. | 2015 | Arch. Oral Biol. | pmid:25455128 |
Cotogni P et al. | The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients. | 2015 | Biomed Res Int | pmid:26301250 |
Dodington DW et al. | Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. | 2015 | J. Nutr. | pmid:26423734 |
Bobiński R and Mikulska M | The ins and outs of maternal-fetal fatty acid metabolism. | 2015 | Acta Biochim. Pol. | pmid:26345097 |
Hieda K et al. | Pharmacological effect of functional foods with a hypotensive action. | 2015 | Nippon Yakurigaku Zasshi | pmid:26165340 |
Kawakami Y et al. | Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. | 2015 | Nutr J | pmid:25896182 |
Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
Akimov MG et al. | [The influence of docosahexaenoic acid moiety on cytotoxic activity of 1,2,4-thiadiazole derivatives]. | 2014 Jul-Aug | Biomed Khim | pmid:25249531 |
Kar S | Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. | 2014 Jan-Feb | Am J Ther | pmid:21975796 |
Casanova E et al. | Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. | 2014 Jan-Feb | Biofactors | pmid:23983179 |
Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
Wales KM et al. | N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. | 2014 | PLoS ONE | pmid:25398022 |
Hsiao HM et al. | Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. | 2014 | J. Immunol. | pmid:25320283 |
Rodrigues PO et al. | Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats. | 2014 | Br. J. Nutr. | pmid:24775714 |
Al-Zaubai N et al. | Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25077525 |
Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
Oh DY et al. | A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. | 2014 | Nat. Med. | pmid:24997608 |
Zhang M et al. | Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. | 2014 | J. Neurosci. | pmid:24478369 |
Shinohara M et al. | Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25217660 |
Yao QH et al. | ω-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro. | 2014 | Mol Med Rep | pmid:24276408 |