DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peroxisomal Disorders D018901 5 associated lipids
Birth Weight D001724 23 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Periodontitis D010518 22 associated lipids
Dermatitis D003872 30 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Shock D012769 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Harris WS and Schmitt TL Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. 2014 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:24393427
Ponnampalam EN et al. Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. 2014 Meat Sci. pmid:23643471
Wang S et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. 2014 Clin Nutr pmid:23672804
Katakura M et al. Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2014 Molecules pmid:24642910
Browning LM et al. Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. 2014 J. Nutr. pmid:24647395
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:25011224
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
White PJ et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. 2014 Nat. Med. pmid:24813250
Balas L et al. Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. 2014 Biochimie pmid:24262603
Vandal M et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. 2014 J. Neurochem. pmid:24345162
Berasategi I et al. Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. 2014 Meat Sci. pmid:24334039
Zhao JP et al. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. 2014 PLoS ONE pmid:24454790
Harden CJ et al. Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. 2014 Nutr Res pmid:24418242
Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
Hashimoto M et al. Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. 2014 J. Pharmacol. Sci. pmid:24561447
Ciaccio CE and Girdhar M Effect of maternal ω3 fatty acid supplementation on infant allergy. 2014 Ann. Allergy Asthma Immunol. pmid:24565593
Abdel-Dayem MA et al. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. 2014 Drugs R D pmid:24733439
Höper AC et al. Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. 2014 J. Nutr. pmid:24285691
Walker CG et al. Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. 2014 Br. J. Nutr. pmid:24063767
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014