DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peroxisomal Disorders D018901 5 associated lipids
Birth Weight D001724 23 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Periodontitis D010518 22 associated lipids
Dermatitis D003872 30 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Shock D012769 11 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Sharma AK and Rohrer B Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. 2007 Curr. Eye Res. pmid:17453946
Thid D et al. DHA-induced changes of supported lipid membrane morphology. 2007 Langmuir pmid:17455967
Stark KD et al. Docosahexaenoic acid and n-6 docosapentaenoic acid supplementation alter rat skeletal muscle fatty acid composition. 2007 Lipids Health Dis pmid:17459159
Burns T et al. Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. 2007 Pharmacotherapy pmid:17461697
McKenney JM and Sica D Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. 2007 Pharmacotherapy pmid:17461707
Bonventre JV Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation. 2007 Contrib Nephrol pmid:17464114
von Schacky C n-3 PUFA in CVD: influence of cytokine polymorphism. 2007 Proc Nutr Soc pmid:17466099
Sijben JW and Calder PC Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. 2007 Proc Nutr Soc pmid:17466105
Rossary A et al. Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts. 2007 Biochem. J. pmid:17472580
Das UN Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? 2007 J. Nutr. Biochem. pmid:17475465
Soubias O and Gawrisch K Docosahexaenoyl chains isomerize on the sub-nanosecond time scale. 2007 J. Am. Chem. Soc. pmid:17477528
Victory R et al. Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblasts. 2007 Fertil. Steril. pmid:17482172
Zand H et al. Involvement of PPAR-gamma and p53 in DHA-induced apoptosis in Reh cells. 2007 Mol. Cell. Biochem. pmid:17487454
Kim HY Novel metabolism of docosahexaenoic acid in neural cells. 2007 J. Biol. Chem. pmid:17488715
Metcalf RG et al. Effects of fish-oil supplementation on myocardial fatty acids in humans. 2007 Am. J. Clin. Nutr. pmid:17490956
Krauss-Etschmann S et al. Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. 2007 Am. J. Clin. Nutr. pmid:17490978
Bays H Fish oil composition of Omacor and the GISSI trial. 2007 Am. J. Cardiol. pmid:17493490
Umhau JC Folate and ageing. 2007 Lancet pmid:17499600
O'Connor CI et al. Dietary fish oil supplementation affects serum fatty acid concentrations in horses. 2007 J. Anim. Sci. pmid:17504965
Thomas TR et al. Interaction of exercise training and n-3 fatty acid supplementation on postprandial lipemia. 2007 Appl Physiol Nutr Metab pmid:17510682
Blackford S et al. Necrolytic migratory erythema without glucagonoma: the role of dietary essential fatty acids. 1991 Br. J. Dermatol. pmid:1751353
Brunton S and Collins N Differentiating prescription omega-3-acid ethyl esters (P-OM3) from dietary-supplement omega-3 fatty acids. 2007 Curr Med Res Opin pmid:17519081
Ayalew-Pervanchon A et al. Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17526653
Aires V et al. Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: a comparative study with DAG-containing docosahexaenoic acid. 2007 Biochimie pmid:17532549
Bruno MJ et al. Docosahexaenoic acid alters bilayer elastic properties. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535898
Tsukui T et al. Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. 2007 J. Agric. Food Chem. pmid:17536824
Wennberg M et al. Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. 2007 Br. J. Nutr. pmid:17537290
Mayzaud P et al. Polar and neutral lipid composition in the pelagic tunicate Pyrosoma atlanticum. 2007 Lipids pmid:17541797
Kolar SS et al. Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. 2007 Cancer Res. pmid:17545640
Carlson BA and Kingston JD Docosahexaenoic acid biosynthesis and dietary contingency: Encephalization without aquatic constraint. 2007 Jul-Aug Am. J. Hum. Biol. pmid:17546613
Cunnane SC et al. Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal. 2007 Jul-Aug Am. J. Hum. Biol. pmid:17546620
Joordens JC et al. Preformed dietary DHA: The answer to a scientific question may in practice become translated to its opposite. 2007 Jul-Aug Am. J. Hum. Biol. pmid:17546621
Lucia Bergmann R et al. Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy? 2007 J Perinat Med pmid:17547539
Schonfeld E et al. Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. 2007 Neurochem. Res. pmid:17551831
Strokin M et al. Prostaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2. 2007 J. Neurochem. pmid:17555549
Brenna JT et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. 2007 Am. J. Clin. Nutr. pmid:17556680
Judge MP et al. Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. 2007 Am. J. Clin. Nutr. pmid:17556695
Aspenström-Fagerlund B et al. Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. 2007 Toxicology pmid:17560003
Schwab JM et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. 2007 Nature pmid:17568749
Hardman WE Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. 2007 Nutr Cancer pmid:17571951
Rupp H et al. Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level". 2006 Herz pmid:17575804
Leonardi F et al. Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cells. 2007 Free Radic. Res. pmid:17577735
Miller MR et al. Replacement of fish oil with thraustochytrid Schizochytrium sp. L oil in Atlantic salmon parr (Salmo salar L) diets. 2007 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:17588797
Oe H et al. Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. 2008 Heart pmid:17591648
Gorjão R et al. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. 2007 J. Lipid Res. pmid:17592174
Lauretani F et al. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. 2007 Eur. J. Neurol. pmid:17594339
Del Turco S et al. Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. 2007 Thromb. Haemost. pmid:17598015
Fagali N and Catalá A The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in omega-3 polyunsaturated fatty acids. 2007 Life Sci. pmid:17603083
de Lima TM et al. Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. 2007 Toxicol In Vitro pmid:17604596
Plourde M and Cunnane SC Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. 2007 Appl Physiol Nutr Metab pmid:17622276
Saifullah A et al. Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study. 2007 Nephrol. Dial. Transplant. pmid:17623719
Sorgi PJ et al. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. 2007 Nutr J pmid:17629918
Duraisamy Y et al. Differential incorporation of docosahexaenoic acid into distinct cholesterol-rich membrane raft domains. 2007 Biochem. Biophys. Res. Commun. pmid:17631858
Kato T et al. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. 2007 Nutr Cancer pmid:17640164
Prescription fish oil. 2007 Harv Health Lett pmid:17642082
Omega-3 might ease depression, enhance mind & memory. There's a growing body of evidence that DHA benefits gray matter, but it's not a cure-all, say researchers. 2007 Duke Med Health News pmid:17649598
Kim YJ and Chung HY Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. 2007 J Med Food pmid:17651056
Galli C et al. Eicosapentaenoic acid for prevention of major coronary events. 2007 Lancet pmid:17658383
Dullemeijer C et al. Erythrocyte folate and plasma DHA in the FACIT study. 2007 Lancet pmid:17658386
Okuyama H et al. In vivo conversion of triacylglycerol to docosahexaenoic acid-containing phospholipids in a thraustochytrid-like microorganism, strain 12B. 2007 Biotechnol. Lett. pmid:17660943
Li Q et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. 2007 Arch. Biochem. Biophys. pmid:17662956
Turck D Later effects of breastfeeding practice: the evidence. 2007 Nestle Nutr Workshop Ser Pediatr Program pmid:17664895
Michaelsen KF et al. Whole cow's milk: why, what and when? 2007 Nestle Nutr Workshop Ser Pediatr Program pmid:17664906
Chapman DJ Breastfeeding and visual development of children. 2007 J Hum Lact pmid:17666540
Serkov IV et al. Interaction of docosahexaenoic acid derivatives with mitochondria. 2007 May-Jun Dokl. Biol. Sci. pmid:17668617
Mukherjee PK et al. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670935
Mukherjee PK et al. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670936
Geppert J et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. 2008 Br. J. Nutr. pmid:17678567
Bulbul M et al. Effect of docosahexaenoic acid on macrophage functions of rats. 2007 Immunobiology pmid:17678716
Florent-Béchard S et al. Towards a nutritional approach for prevention of Alzheimer's disease: biochemical and cellular aspects. 2007 J. Neurol. Sci. pmid:17681547
Cansev M and Wurtman RJ Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. 2007 Neuroscience pmid:17683870
Kelley DS et al. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. 2007 Am. J. Clin. Nutr. pmid:17684201
Haubner L et al. The effects of maternal dietary docosahexaenoic acid intake on rat pup myelin and the auditory startle response. 2007 Dev. Neurosci. pmid:17684314
Koletzko B et al. Dietary fat intakes for pregnant and lactating women. 2007 Br. J. Nutr. pmid:17688705
Tsuzuki T et al. Anti-angiogenic effects of conjugated docosahexaenoic acid in vitro and in vivo. 2007 Biosci. Biotechnol. Biochem. pmid:17690464
Burdge GC et al. The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17693069
Brockman HL et al. Structural determinants of the packing and electrostatic behavior of unsaturated phosphoglycerides. 2007 Biophys. J. pmid:17693462
Ganuza E and Izquierdo MS Lipid accumulation in Schizochytrium G13/2S produced in continuous culture. 2007 Appl. Microbiol. Biotechnol. pmid:17694304
Gronowitz E et al. Docosahexaenoic acid is associated with endosteal circumference in long bones in young males with cystic fibrosis. 2008 Br. J. Nutr. pmid:17697399
Castañeda-Gutiérrez E et al. Effect of supplementation with calcium salts of fish oil on n-3 fatty acids in milk fat. 2007 J. Dairy Sci. pmid:17699033
Donadio JV et al. Is body size a biomarker for optimizing dosing of omega-3 polyunsaturated fatty acids in the treatment of patients with IgA nephropathy? 2006 Clin J Am Soc Nephrol pmid:17699310
Hogg RJ et al. Efficacy of omega-3 fatty acids in children and adults with IgA nephropathy is dosage- and size-dependent. 2006 Clin J Am Soc Nephrol pmid:17699343
Ylönen SK et al. The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism. 2008 Eur J Clin Nutr pmid:17700648
Abély M [Treatment of airway inflammation in cystic fibrosis]. 2007 Arch Pediatr pmid:17702549
Stark KD et al. Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition. 2007 J. Lipid Res. pmid:17703057
Calder PC Dietary arachidonic acid: harmful, harmless or helpful? 2007 Br. J. Nutr. pmid:17705889
Besson N et al. Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages. 2006 Lipids pmid:17707985
Huang MC et al. Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoate. 2007 J. Nutr. pmid:17709441
Mitmesser SH and Jensen CL Roles of long-chain polyunsaturated fatty acids in the term infant: developmental benefits. 2007 Jul-Aug Neonatal Netw pmid:17710956
Arterburn LM et al. Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food. 2007 Lipids pmid:17713804
Sahlin C et al. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease. 2007 Eur. J. Neurosci. pmid:17714184
Igarashi M et al. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. 2007 J. Lipid Res. pmid:17715424
Kolar SS et al. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17717041
Bueno AA et al. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. 2008 Pflugers Arch. pmid:17717684
Himmelfarb J et al. Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. 2007 J Ren Nutr pmid:17720098
Hooijmans CR et al. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). 2007 Neurobiol. Dis. pmid:17720508
Wallström P et al. A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden). 2007 Cancer Causes Control pmid:17726648
Kaur P et al. Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. 2007 Toxicol. Sci. pmid:17728287
Puri BK et al. A 31-phosphorus neurospectroscopy study of omega-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17761409
Shah M et al. Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. 2007 Diabetes Care pmid:17804680