Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mori TA | Dietary n-3 PUFA and CVD: a review of the evidence. | 2014 | Proc Nutr Soc | pmid:24119287 |
Hua J et al. | The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25146982 |
Navarro-Guillén C et al. | Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. | 2014 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:24120522 |
Fedorova-Dahms I et al. | A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms. | 2014 | Food Chem. Toxicol. | pmid:24333867 |
Lee EJ et al. | Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. | 2014 | Biochim. Biophys. Acta | pmid:24120917 |
Amiano P et al. | Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. | 2014 | Nutr Metab Cardiovasc Dis | pmid:24360762 |
Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
Currais A et al. | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. | 2014 | Aging Cell | pmid:24341874 |
Lager S et al. | Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452383 |
Keelan JA | Letter to the editor: "fatty acids and placental transport: insight or in vitro artifact?". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452382 |
Hsiao HM et al. | Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. | 2014 | J. Immunol. | pmid:25320283 |
Hiram R et al. | Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25281570 |
Arnardottir HH et al. | Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. | 2014 | J. Immunol. | pmid:25217168 |
Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
Rodrigues PO et al. | Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats. | 2014 | Br. J. Nutr. | pmid:24775714 |
Torok VA et al. | Influence of dietary docosahexaenoic acid supplementation on the overall rumen microbiota of dairy cows and linkages with production parameters. | 2014 | Can. J. Microbiol. | pmid:24779577 |
Burns-Whitmore B et al. | Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. | 2014 | Nutr J | pmid:24673793 |
Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
Makrides M et al. | Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation. | 2014 | JAMA | pmid:24794375 |
Jung JY et al. | Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. | 2014 | Acta Derm. Venereol. | pmid:24553997 |
Mirakaj V et al. | Vagus nerve controls resolution and pro-resolving mediators of inflammation. | 2014 | J. Exp. Med. | pmid:24863066 |
Chen R et al. | [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. | 2014 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24796591 |
Ooi SY and Andrews JM | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803245 |
Chan SS and Hart AR | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease--authors' reply. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803246 |
Betsholtz C | Physiology: Double function at the blood-brain barrier. | 2014 | Nature | pmid:24828036 |
Nguyen LN et al. | Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. | 2014 | Nature | pmid:24828044 |
Chua A et al. | Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. | 2014 | Environ. Mol. Mutagen. | pmid:24828973 |
Hong S et al. | Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25273880 |
Ma QL et al. | Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. | 2014 | J. Neurosci. | pmid:24849348 |
Ramon S et al. | The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? | 2014 | J. Immunol. | pmid:25392529 |
Hughbanks-Wheaton DK et al. | Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: the 4-year DHAX trial. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25015354 |
Velten M et al. | Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. | 2014 | J. Nutr. | pmid:24453131 |
Mereghetti P et al. | A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid. | 2014 | Biochim. Biophys. Acta | pmid:25018005 |
Lager S et al. | Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25143349 |
Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Sato K et al. | Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619. | 2014 | Biol. Pharm. Bull. | pmid:24369179 |
Nishinaka T et al. | Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. | 2014 | J. Pharmacol. Sci. | pmid:24758921 |
Torres M et al. | Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. | 2014 | Biochim. Biophys. Acta | pmid:24374316 |
Nagao K et al. | Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells. | 2014 | J Oleo Sci | pmid:25213447 |
De Felice C et al. | Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. | 2014 | Neurobiol. Dis. | pmid:24769161 |
Zhang M et al. | Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. | 2014 | J. Neurosci. | pmid:24478369 |
Kabeya N et al. | Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. | 2014 | J. Biotechnol. | pmid:24389067 |
Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
Casanova E et al. | Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. | 2014 | Biochim. Biophys. Acta | pmid:24486445 |
Taltavull N et al. | Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome. | 2014 | Lipids Health Dis | pmid:24512213 |
Nanjappa D et al. | Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. | 2014 | Mar Drugs | pmid:24445306 |
Begum G et al. | Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. | 2014 | J. Neurosci. | pmid:24599472 |
Koppenol A et al. | Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. | 2014 | Poult. Sci. | pmid:24604849 |
Gil-Zamorano J et al. | Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. | 2014 | J. Nutr. | pmid:24623846 |
Buckley CD et al. | Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. | 2014 | Immunity | pmid:24656045 |
Cui ZG et al. | Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. | 2014 | Chem. Biol. Interact. | pmid:24661947 |
Dayaker G et al. | Total synthesis of neuroprotectin D1 analogues derived from omega-6 docosapentaenoic acid (DPA) and adrenic acid (AdA) from a common pivotal, late-stage intermediate. | 2014 | J. Org. Chem. | pmid:24571431 |
Adarme-Vega TC et al. | Towards sustainable sources for omega-3 fatty acids production. | 2014 | Curr. Opin. Biotechnol. | pmid:24607804 |
Aronow ME and Chew EY | Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. | 2014 | Curr Opin Ophthalmol | pmid:24614146 |
Xue M et al. | Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo. | 2014 | J. Nutr. Biochem. | pmid:24290517 |
Levy BD and Serhan CN | Resolution of acute inflammation in the lung. | 2014 | Annu. Rev. Physiol. | pmid:24313723 |
Dendelé B et al. | Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. | 2014 | Chem. Biol. Interact. | pmid:24246761 |
Murali G et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24332315 |
Walhovd KB et al. | Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. | 2014 | Neurobiol. Aging | pmid:24332985 |
Eto M et al. | A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24333445 |
Zanfini A et al. | GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. | 2014 | Lipids | pmid:25208498 |
Sertoglu E et al. | Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. | 2014 | Chem. Phys. Lipids | pmid:24384240 |
Stoffel W et al. | Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. | 2014 | EMBO Rep. | pmid:24378641 |
Hong S et al. | Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. | 2014 | Chem. Biol. | pmid:25200603 |
Jiang M et al. | Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. | 2014 | Mar Drugs | pmid:24608969 |
Luxwolda MF et al. | Interrelationships between maternal DHA in erythrocytes, milk and adipose tissue. Is 1 wt% DHA the optimal human milk content? Data from four Tanzanian tribes differing in lifetime stable intakes of fish. | 2014 | Br. J. Nutr. | pmid:24175990 |
Gladine C et al. | Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. | 2014 | PLoS ONE | pmid:24558496 |
Hixson SM et al. | Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. | 2014 | Lipids | pmid:24264359 |
Chen F et al. | Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. | 2014 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:24072678 |
Eady TN et al. | Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. | 2014 | Neurobiol. Dis. | pmid:24063996 |
Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
Izquierdo MS et al. | Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. | 2013 | Br. J. Nutr. | pmid:23046500 |
Kasuya F et al. | Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. | 2013 | J Enzyme Inhib Med Chem | pmid:22299587 |
Sánchez-MartÃn MJ et al. | Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. | 2013 | Chembiochem | pmid:23447332 |
Pacetti D et al. | Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). | 2013 | J. Agric. Food Chem. | pmid:23531042 |
Kuratko CN et al. | The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. | 2013 | Nutrients | pmid:23877090 |
Vigerust NF et al. | Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. | 2013 | Eur J Nutr | pmid:22923017 |
Marty-Roix R and Lien E | (De-) oiling inflammasomes. | 2013 | Immunity | pmid:23809158 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Zhang L et al. | Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. | 2013 | Bioresour. Technol. | pmid:23751810 |
Janczyk W et al. | Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. | 2013 | BMC Pediatr | pmid:23702094 |
GarcÃa-Sastre A | Lessons from lipids in the fight against influenza. | 2013 | Cell | pmid:23827671 |
Chen HF and Su HM | Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. | 2013 | J. Nutr. Biochem. | pmid:22818715 |
Mortensen K and Tawia S | Sustained breastfeeding. | 2013 | Breastfeed Rev | pmid:23600325 |
Sadli N et al. | Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. | 2013 | Cell. Physiol. Biochem. | pmid:23942088 |
Crawford MA et al. | A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23206328 |
Kim K et al. | A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. | 2013 | Bioresour. Technol. | pmid:23206808 |
Stanley WC et al. | Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. | 2013 | J Cardiovasc Transl Res | pmid:24065618 |