Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li D et al. | Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. | 2013 | Mucosal Immunol | pmid:23462912 |
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Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | 2002 | Mol. Vis. | pmid:12355064 |
Li F et al. | DHA does not protect ELOVL4 transgenic mice from retinal degeneration. | 2009 | Mol. Vis. | pmid:19536303 |
Gross EA et al. | G239T mutation in Repeat 1 of human IRBP: possible implications for more than one binding site in a single repeat. | 2000 | Mol. Vis. | pmid:10756181 |
Sheets KG et al. | Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. | 2013 | Mol. Vis. | pmid:23922492 |
Sheets KG et al. | Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. | 2010 | Mol. Vis. | pmid:20216940 |
Li F et al. | High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. | 2010 | Mol. Vis. | pmid:20806040 |
Ollero M et al. | Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: implications for sperm lipoperoxidative damage. | 2000 | Mol. Reprod. Dev. | pmid:10657052 |
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Rao JS et al. | Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. | 2007 | Mol. Psychiatry | pmid:16983392 |
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Calderaro V et al. | Docosahexaenoic acid and signaling pathways in rabbit colon. | 1994 | Mol. Pharmacol. | pmid:8183254 |
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Bazan NG et al. | Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. | 2011 | Mol. Neurobiol. | pmid:21918832 |
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Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
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Lengqvist J et al. | Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. | 2004 | Mol. Cell Proteomics | pmid:15073272 |
Ding WQ et al. | Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. | 2004 | Mol. Cancer Ther. | pmid:15367705 |
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