Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vyncke KE et al. | Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. | 2013 | Nutrition | pmid:23312763 |
Umhau JC et al. | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. | 2013 | PLoS ONE | pmid:24098376 |
Renganathan K et al. | CEP biomarkers as potential tools for monitoring therapeutics. | 2013 | PLoS ONE | pmid:24098476 |
Xu J et al. | Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. | 2013 | FEBS J. | pmid:24128189 |
Kimura R et al. | DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. | 2013 | J. Lipid Res. | pmid:24133194 |
Kautharapu KB et al. | Growth condition optimization for docosahexaenoic acid (DHA) production by Moritella marina MP-1. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23111600 |
Méndez L et al. | Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. | 2013 | Free Radic. Biol. Med. | pmid:23159545 |
Cooke M et al. | Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. | 2013 | Mol. Cell. Endocrinol. | pmid:23159987 |
Al-Hilal M et al. | Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. | 2013 | J. Lipid Res. | pmid:23160180 |
Walker CG et al. | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. | 2013 | Nutrition | pmid:23102888 |
Yang T et al. | N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. | 2013 | J. Nutr. Biochem. | pmid:22854319 |
Faizan M et al. | Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). | 2013 | Int J Vitam Nutr Res | pmid:25008014 |
Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
Nordgren TM et al. | Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. | 2013 | Respir. Res. | pmid:23663457 |
Dacks PA et al. | Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. | 2013 | J Nutr Health Aging | pmid:23459977 |
Skilton MR et al. | High intake of dietary long-chain ω-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008. | 2013 | Hypertension | pmid:23460284 |
Kurihara T et al. | Resolvin D2 restores neutrophil directionality and improves survival after burns. | 2013 | FASEB J. | pmid:23430978 |
Gustafson KM et al. | Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23433688 |
Kondo T et al. | Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. | 2013 | Cell Stem Cell | pmid:23434393 |
GarcÃa-Layana A et al. | Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. | 2013 | Nutrients | pmid:23434908 |
Williams JJ et al. | N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. | 2013 | PLoS ONE | pmid:23437099 |
McNamara RK et al. | Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. | 2013 | J Psychiatr Res | pmid:23759469 |
Nielsen G et al. | Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. | 2013 | Basic Clin. Pharmacol. Toxicol. | pmid:23724868 |
Mayer-Davis EJ et al. | Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. | 2013 | Diabetes Care | pmid:23801797 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
Kaur G et al. | Orally administered [¹â´C]DPA and [¹â´C]DHA are metabolised differently to [¹â´C]EPA in rats. | 2013 | Br. J. Nutr. | pmid:22578196 |
Mozurkewich EL et al. | The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531328 |
Romero VC et al. | Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531329 |
Bagley HN et al. | Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. | 2013 | J Obes | pmid:23533720 |
Dangour AD and Allen E | Do omega-3 fats boost brain function in adults? Are we any closer to an answer? | 2013 | Am. J. Clin. Nutr. | pmid:23535110 |
Kitamura F et al. | Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change locomotor activity. | 2013 | J Oleo Sci | pmid:23535307 |
Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
Fedor DM et al. | The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. | 2013 | Metab Syndr Relat Disord | pmid:23170930 |
Marty-Roix R and Lien E | (De-) oiling inflammasomes. | 2013 | Immunity | pmid:23809158 |
Yan Y et al. | Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. | 2013 | Immunity | pmid:23809162 |
Wu A et al. | Exercise facilitates the action of dietary DHA on functional recovery after brain trauma. | 2013 | Neuroscience | pmid:23811071 |
Sugasini D and Lokesh BR | Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. | 2013 | Mol. Cell. Biochem. | pmid:23812902 |
Fukui M et al. | EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. | 2013 | J. Cell. Biochem. | pmid:22903547 |
Stark MJ et al. | Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. | 2013 | Reproduction | pmid:23813449 |
Rupp TP et al. | Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. | 2013 | Cardiology | pmid:23816637 |
Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
Wu Z et al. | Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. | 2013 | Brain Res. Bull. | pmid:23817050 |
Erken HA et al. | Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. | 2013 | High Alt. Med. Biol. | pmid:24377343 |
Oelrich B et al. | Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:21924882 |
Tapsell LC et al. | Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. | 2013 | BMC Public Health | pmid:24369765 |
Ribeiro T et al. | Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. | 2013 | Br. Poult. Sci. | pmid:24397512 |
Zhang G et al. | Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23553837 |
Rayapudi S et al. | Vitamin A and fish oils for retinitis pigmentosa. | 2013 | Cochrane Database Syst Rev | pmid:24357340 |
Santos-Soto IJ et al. | Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. | 2013 | PLoS ONE | pmid:24349072 |
Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
Janczyk W et al. | Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. | 2013 | BMC Pediatr | pmid:23702094 |
Cortina MS et al. | Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23702780 |
Nyuar KB et al. | Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23706881 |
Terrando N et al. | Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. | 2013 | FASEB J. | pmid:23709617 |
Fietkau R et al. | A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. | 2013 | Cancer | pmid:23765693 |
Jiang LH et al. | Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. | 2013 | Pharm Biol | pmid:23767459 |
Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
Mobraten K et al. | Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. | 2013 | Lipids Health Dis | pmid:23849180 |
Martins DA et al. | Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. | 2013 | Mar Drugs | pmid:23807546 |
Brahmbhatt V et al. | Protective effects of dietary EPA and DHA on ischemia-reperfusion-induced intestinal stress. | 2013 | J. Nutr. Biochem. | pmid:22819560 |
Kagan ML et al. | Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. | 2013 | Lipids Health Dis | pmid:23855409 |
Lee HN and Surh YJ | Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. | 2013 | Biochem. Pharmacol. | pmid:23856291 |
Benton D et al. | Supplementation with DHA and the psychological functioning of young adults. | 2013 | Br. J. Nutr. | pmid:22715808 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Eickmeier O et al. | Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. | 2013 | Mucosal Immunol | pmid:22785226 |
Kusunoki C et al. | Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23131562 |
Li C et al. | High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. | 2013 | Bioresour. Technol. | pmid:23131649 |
Nicholson T et al. | The role of marine n-3 fatty acids in improving cardiovascular health: a review. | 2013 | Food Funct | pmid:23325431 |
Hamaoka N et al. | Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. | 2013 | J. Food Sci. | pmid:23915081 |
Jing K et al. | Omega-3 polyunsaturated fatty acids and cancer. | 2013 | Anticancer Agents Med Chem | pmid:23919748 |
Pagán A et al. | Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23921142 |
Harsløf LB et al. | FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. | 2013 | Am. J. Clin. Nutr. | pmid:23636240 |
Kangari H et al. | Short-term consumption of oral omega-3 and dry eye syndrome. | 2013 | Ophthalmology | pmid:23642375 |
Tanghe S et al. | Echium oil and linseed oil as alternatives for fish oil in the maternal diet: Blood fatty acid profiles and oxidative status of sows and piglets. | 2013 | J. Anim. Sci. | pmid:23658328 |
Gow RV et al. | Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23664595 |
Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
Trofimiuk E and Braszko JJ | Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. | 2013 | Physiol. Behav. | pmid:23672853 |
Rajasagi NK et al. | Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23942967 |
Mühlroth A et al. | Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. | 2013 | Mar Drugs | pmid:24284429 |
Harris WS et al. | Omega-3 fatty acids and cardiovascular disease: new developments and applications. | 2013 | Postgrad Med | pmid:24200766 |
Ding N et al. | Short-term effects of different fish oil formulations on tissue absorption of docosahexaenoic acid in mice fed high- and low-fat diets. | 2013 | J Oleo Sci | pmid:24200935 |
Pomponi M et al. | Plasma levels of n-3 fatty acids in bipolar patients: deficit restricted to DHA. | 2013 | J Psychiatr Res | pmid:23207113 |
Yee LD et al. | The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. | 2013 | Mol Nutr Food Res | pmid:23213007 |
Valentine CJ et al. | Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors. | 2013 | Breastfeed Med | pmid:22568471 |
Kilpinen L et al. | Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. | 2013 | J. Lipid Res. | pmid:23271708 |
Tomita T et al. | High concentrations of omega-3 fatty acids are associated with the development of atrial fibrillation in the Japanese population. | 2013 | Heart Vessels | pmid:22696184 |
Makrides M | DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22698951 |
Becerir C et al. | The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. | 2013 | J Enzyme Inhib Med Chem | pmid:22591320 |
Innis SM et al. | Long chain omega-3 fatty acids: micronutrients in disguise. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22709913 |
Orr SK et al. | Unesterified docosahexaenoic acid is protective in neuroinflammation. | 2013 | J. Neurochem. | pmid:23919613 |
Andrade-Vieira R et al. | Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. | 2013 | Cancer Biol. Ther. | pmid:24025358 |
Lachance C et al. | Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. | 2013 | PLoS ONE | pmid:24069363 |
Leggieri E et al. | Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. | 2013 | Minerva Pediatr. | pmid:24051972 |
Li D et al. | Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. | 2013 | Mucosal Immunol | pmid:23462912 |
Zou Z et al. | Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. | 2013 | J. Lipid Res. | pmid:24052576 |
Song X et al. | Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. | 2013 | J. Agric. Food Chem. | pmid:24053543 |
Nobili V et al. | The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. | 2013 | J Med Food | pmid:24074360 |
Bogl LH et al. | Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23333726 |
Depner CM et al. | Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. | 2013 | J. Nutr. | pmid:23303872 |
Uusitalo L et al. | Fatty acids in serum and diet--a canonical correlation analysis among toddlers. | 2013 | Matern Child Nutr | pmid:22066932 |