Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
Fernández-González R et al. | Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. | 2014 | Sci. Total Environ. | pmid:24095964 |
Amiano P et al. | Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. | 2014 | Nutr Metab Cardiovasc Dis | pmid:24360762 |
Currais A et al. | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. | 2014 | Aging Cell | pmid:24341874 |
Bernhard W et al. | Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. | 2014 | Eur J Nutr | pmid:24464176 |
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
Jilkova ZM et al. | Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice. | 2014 | Int J Obes (Lond) | pmid:23756677 |
Schuster GU et al. | Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24134486 |
Maitin V et al. | Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. | 2014 | J. Lipid Res. | pmid:24136824 |
Wang S et al. | Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. | 2014 | Clin Nutr | pmid:23672804 |
De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
Katakura M et al. | Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2014 | Molecules | pmid:24642910 |
Browning LM et al. | Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. | 2014 | J. Nutr. | pmid:24647395 |
Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
Hoogeveen EK et al. | Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. | 2014 | Clin J Am Soc Nephrol | pmid:25104273 |
Bispo P et al. | Preparation of triacylglycerols rich in omega-3 fatty acids from sardine oil using a Rhizomucor miehei lipase: focus in the EPA/DHA ratio. | 2014 | Appl. Biochem. Biotechnol. | pmid:24293255 |
Nguyen LN et al. | Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. | 2014 | Nature | pmid:24828044 |
Chua A et al. | Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. | 2014 | Environ. Mol. Mutagen. | pmid:24828973 |
Hong S et al. | Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25273880 |
Ma QL et al. | Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. | 2014 | J. Neurosci. | pmid:24849348 |
Tungen JE et al. | Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. | 2014 | J. Nat. Prod. | pmid:25247845 |
McCauley LK et al. | Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. | 2014 | J. Immunol. | pmid:24890726 |
Serhan CN | Pro-resolving lipid mediators are leads for resolution physiology. | 2014 | Nature | pmid:24899309 |
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:24834713 | |
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:25011224 | |
Skender B et al. | DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. | 2014 | Biochim. Biophys. Acta | pmid:24953781 |
Zhao Z and Zlokovic BV | Blood-brain barrier: a dual life of MFSD2A? | 2014 | Neuron | pmid:24853933 |
Hoffman DR et al. | Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial. | 2014 | JAMA Ophthalmol | pmid:24805262 |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
Aursnes M et al. | Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. | 2014 | Org. Biomol. Chem. | pmid:24253202 |
Shimamoto C et al. | Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. | 2014 | Hum. Mol. Genet. | pmid:25027319 |
White PJ et al. | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. | 2014 | Nat. Med. | pmid:24813250 |
Balas L et al. | Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. | 2014 | Biochimie | pmid:24262603 |
Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
Siddesha JM et al. | Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. | 2014 | Cell. Signal. | pmid:24447911 |
Shao Z et al. | Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24458713 |
Steffens JP et al. | Testosterone regulates bone response to inflammation. | 2014 | Horm. Metab. Res. | pmid:24526374 |
Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
Torres M et al. | Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. | 2014 | Biochim. Biophys. Acta | pmid:24374316 |
Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
Vandal M et al. | Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. | 2014 | J. Neurochem. | pmid:24345162 |
Prostek A et al. | The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. | 2014 | Lipids Health Dis | pmid:24387137 |
Yaxin W et al. | Resolvin D1 attenuates lipopolysaccharide induced acute lung injury through CXCL-12/CXCR4 pathway. | 2014 | J. Surg. Res. | pmid:24387839 |
Shaikh NA et al. | Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. | 2014 | Mol. Cell. Biochem. | pmid:25185754 |
O'Connor-Robison CI et al. | The impact of dietary long-chain polyunsaturated fatty acids on bone and cartilage in gilts and sows. | 2014 | J. Anim. Sci. | pmid:25184850 |
Wójcik C et al. | Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. | 2014 | J. Cell. Mol. Med. | pmid:24834523 |
De Felice C et al. | Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. | 2014 | Neurobiol. Dis. | pmid:24769161 |
Saito H | Lipid characteristics of five epinephelinae fishes, Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti, in the Coral Reef. | 2014 | J Oleo Sci | pmid:24717545 |
Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
Adarme-Vega TC et al. | Towards sustainable sources for omega-3 fatty acids production. | 2014 | Curr. Opin. Biotechnol. | pmid:24607804 |
Aronow ME and Chew EY | Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. | 2014 | Curr Opin Ophthalmol | pmid:24614146 |
Wang Q et al. | Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. | 2014 | J. Immunol. | pmid:24646745 |
Pottala JV et al. | Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. | 2014 | Neurology | pmid:24453077 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
Harden CJ et al. | Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. | 2014 | Nutr Res | pmid:24418242 |
Asai M et al. | [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. | 2014 | Nippon Yakurigaku Zasshi | pmid:24420133 |
Jin M et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. | 2014 | J Med Food | pmid:24460246 |
Chen MY et al. | Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. | 2014 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:24444393 |
Nozue T et al. | Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study. | 2014 | Cardiovasc Diabetol | pmid:24410834 |
Freund Levi Y et al. | Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. | 2014 | J. Intern. Med. | pmid:24410954 |
O'Callaghan N et al. | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. | 2014 | Nutrition | pmid:24342530 |
Patterson AC et al. | The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. | 2014 | Br. J. Nutr. | pmid:23920312 |
Martorell M et al. | Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. | 2014 | Food Funct | pmid:24955731 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Kitessa SM et al. | DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. | 2014 | Nutrients | pmid:24858407 |
Murali G et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24332315 |
Walhovd KB et al. | Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. | 2014 | Neurobiol. Aging | pmid:24332985 |
Eto M et al. | A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24333445 |
Nelson JW et al. | ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24259417 |
O'Sullivan A et al. | Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. | 2014 | J. Nutr. | pmid:24259553 |
Cipollina C et al. | Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. | 2014 | Biochim. Biophys. Acta | pmid:24594225 |
Siddiqui RA et al. | Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. | 2014 | Bioorg. Med. Chem. | pmid:24556504 |
Hashimoto M et al. | Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. | 2014 | J. Pharmacol. Sci. | pmid:24561447 |
Ciaccio CE and Girdhar M | Effect of maternal ω3 fatty acid supplementation on infant allergy. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24565593 |
von Schacky C | Omega-3 index and cardiovascular health. | 2014 | Nutrients | pmid:24566438 |
Bauer I et al. | Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. | 2014 | Hum Psychopharmacol | pmid:24285504 |
Nehra D et al. | Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? | 2014 | J. Surg. Res. | pmid:24576779 |
Abdel-Dayem MA et al. | Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. | 2014 | Drugs R D | pmid:24733439 |
Höper AC et al. | Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. | 2014 | J. Nutr. | pmid:24285691 |
Rutkowsky JM et al. | Acylcarnitines activate proinflammatory signaling pathways. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24760988 |
Zhao H et al. | Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. | 2014 | BMC Pulm Med | pmid:24742272 |
DiNicolantonio JJ et al. | A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. | 2014 | Nutr Cancer | pmid:25356937 |
Boca SM et al. | Testing multiple biological mediators simultaneously. | 2014 | Bioinformatics | pmid:24202540 |
Peoples GE and McLennan PL | Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model. | 2014 | Br. J. Nutr. | pmid:24229620 |
Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
Hong S et al. | Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. | 2014 | Chem. Biol. | pmid:25200603 |
Cho Y et al. | Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24495951 |
Park J et al. | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. | 2014 | PLoS ONE | pmid:24465474 |
Eady TN et al. | Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. | 2014 | Neurobiol. Dis. | pmid:24063996 |
Tang H et al. | Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. | 2014 | J. Immunol. | pmid:25172497 |
Montgomery P et al. | Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. | 2014 | J Sleep Res | pmid:24605819 |
Walker CG et al. | Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. | 2014 | Br. J. Nutr. | pmid:24063767 |
Zheng MG et al. | Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. | 2014 | Biotechnol. Lett. | pmid:24068506 |
Bahety P et al. | Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. | 2014 | PLoS ONE | pmid:24587236 |
Gregory MK et al. | Effect of dietary canola oil on long-chain omega-3 fatty acid content in broiler hearts. | 2014 | J Anim Physiol Anim Nutr (Berl) | pmid:23510129 |
Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |