Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
Hong WK et al. | Growth of the oleaginous microalga Aurantiochytrium sp. KRS101 on cellulosic biomass and the production of lipids containing high levels of docosahexaenoic acid. | 2012 | Bioprocess Biosyst Eng | pmid:21959581 |
Cruz-Hernandez C et al. | Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. | 2012 | Nutrients | pmid:23201848 |
Martin CR et al. | The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129201 |
Begum G et al. | DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. | 2012 | J. Neurochem. | pmid:22129278 |
López-Alarcón M et al. | Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. | 2012 | Nutrition | pmid:22079797 |
Skulas-Ray AC et al. | Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. | 2012 | Ann Behav Med | pmid:22865498 |
Le HD et al. | Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. | 2012 | JPEN J Parenter Enteral Nutr | pmid:22038210 |
Towhidi A and Parks JE | Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. | 2012 | J. Assist. Reprod. Genet. | pmid:22869241 |
Tillman EM et al. | Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. | 2012 | JPEN J Parenter Enteral Nutr | pmid:22038211 |
Fasano E et al. | DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. | 2012 | Biochim. Biophys. Acta | pmid:22898250 |
Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
Tyburczy C et al. | Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. | 2012 | Br. J. Nutr. | pmid:22040360 |
Schmitt D et al. | Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. | 2012 | Food Chem. Toxicol. | pmid:22898615 |
Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
Swanson D et al. | Omega-3 fatty acids EPA and DHA: health benefits throughout life. | 2012 | Adv Nutr | pmid:22332096 |
Berson EL et al. | ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. | 2012 | Arch. Ophthalmol. | pmid:22332205 |
Beezhold BL and Johnston CS | Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. | 2012 | Nutr J | pmid:22333737 |
Rondanelli M et al. | Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. | 2012 | Nutr Neurosci | pmid:22334085 |
Rockett BD et al. | Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. | 2012 | J. Lipid Res. | pmid:22315394 |
Hjorth E and Freund-Levi Y | Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22316559 |
Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
Jackson KG et al. | Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype-insights from the SATgenε study. | 2012 | Mol Nutr Food Res | pmid:23097177 |
Liu Y et al. | Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. | 2012 | J. Nutr. | pmid:23014495 |
Saito H and Ishikawa S | Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii. | 2012 | J Oleo Sci | pmid:23018852 |
Felbinger TW et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235078 |
Bistrian BR | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235079 |
König K et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235080 |
Mas E et al. | Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. | 2012 | Clin. Chem. | pmid:22912397 |
Schmitt D et al. | Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. | 2012 | Food Chem. Toxicol. | pmid:22960629 |
Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
Huang TY et al. | A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. | 2012 | Bioresour. Technol. | pmid:22929740 |
Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
Feng Z et al. | Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. | 2012 | Antioxid. Redox Signal. | pmid:21905985 |
Moreno-Indias I et al. | The effect of diet and DHA addition on the sensory quality of goat kid meat. | 2012 | Meat Sci. | pmid:21907501 |
Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
Cortina MS et al. | Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. | 2012 | Arch. Ophthalmol. | pmid:21911652 |
Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
Mil-Homens D et al. | The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia. | 2012 | FEMS Microbiol. Lett. | pmid:22150831 |
Rupp H et al. | Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". | 2012 | Can. J. Physiol. Pharmacol. | pmid:22188440 |
Peters BS et al. | The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. | 2012 | Clin Ther | pmid:22212377 |
Chen WY et al. | Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. | 2012 | J. Nutr. Biochem. | pmid:21497498 |
Munro IA and Garg ML | Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. | 2012 | Br. J. Nutr. | pmid:22214842 |
Basselin M et al. | Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. | 2012 | Brain Res. Bull. | pmid:22178644 |
van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
Chen HF and Su HM | Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. | 2012 | J. Nutr. Biochem. | pmid:21543216 |
Bang S et al. | 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. | 2012 | Br. J. Pharmacol. | pmid:21718307 |
Deike E et al. | The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. | 2012 | J Ren Nutr | pmid:22285316 |
Trépanier MO et al. | Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. | 2012 | Epilepsy Res. | pmid:22285511 |
Signori C et al. | Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. | 2012 | Eur J Clin Nutr | pmid:22669332 |
Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
Kitson AP et al. | Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749739 |
Johnson M et al. | Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. | 2012 | Atten Defic Hyperact Disord | pmid:22753087 |
Quinn EA and Kuzawa CW | A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. | 2012 | Acta Paediatr. | pmid:22759234 |
Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
Hacioglu G et al. | Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. | 2012 | Folia Histochem. Cytobiol. | pmid:22763967 |
Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
Oblozinský M et al. | New pharmaceutical insights related to the pathways of PUFAs. | 2012 | Ceska Slov Farm | pmid:23251954 |
Calandria JM et al. | Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. | 2012 | J. Biol. Chem. | pmid:22511762 |
Lifschitz C | New actions for old nutrients. | 2012 | Acta Sci Pol Technol Aliment | pmid:22493160 |
Kwak SM et al. | Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. | 2012 | Arch. Intern. Med. | pmid:22493407 |
Liu SH et al. | Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. | 2012 | Brain Res. | pmid:22440676 |
Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
Trikalinos TA et al. | Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. | 2012 | J Clin Epidemiol | pmid:22047889 |
Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
Lorenzetti A et al. | Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. | 2012 | Acta Biomed | pmid:23393918 |
Glover KE et al. | Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. | 2012 | J. Dairy Sci. | pmid:22612917 |
Corsetto PA et al. | Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. | 2012 | Cell Biochem. Biophys. | pmid:22622660 |
Serra-Majem L et al. | Dietary methods and biomarkers of omega 3 fatty acids: a systematic review. | 2012 | Br. J. Nutr. | pmid:22591904 |
Bell S et al. | The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. | 2012 | Clin. Nephrol. | pmid:22595386 |
Larqué E et al. | Omega 3 fatty acids, gestation and pregnancy outcomes. | 2012 | Br. J. Nutr. | pmid:22591905 |
Hajjaji N et al. | Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. | 2012 | Cancer Chemother. Pharmacol. | pmid:22610354 |
Campoy C et al. | Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. | 2012 | Br. J. Nutr. | pmid:22591907 |
Njoroge SW et al. | DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. | 2012 | J. Lipid Res. | pmid:22095831 |
Angulo J et al. | Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. | 2012 | J. Sci. Food Agric. | pmid:22549272 |
Wielinga PY et al. | Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. | 2012 | Mol Nutr Food Res | pmid:22611002 |
Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
Calder PC | Long-chain fatty acids and inflammation. | 2012 | Proc Nutr Soc | pmid:22369781 |
Kelley DS and Adkins Y | Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. | 2012 | Proc Nutr Soc | pmid:22369859 |
Bernstein AM et al. | A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. | 2012 | J. Nutr. | pmid:22113870 |
Yui K et al. | Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. | 2012 | J Clin Psychopharmacol | pmid:22370992 |
Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |
Maki KC et al. | Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21775113 |
Luxwolda MF et al. | The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21715149 |
Fabelo N et al. | Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. | 2011 Sep-Oct | Mol. Med. | pmid:21717034 |
Shilina NM et al. | [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. | 2011 Sep-Oct | Biomed Khim | pmid:22629608 |
Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
Maki KC et al. | Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. | 2011 Nov-Dec | J Clin Lipidol | pmid:22108152 |
Siddiqui RA et al. | Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. | 2011 Nov-Dec | Biofactors | pmid:22038684 |
Opperman M et al. | Analysis of omega-3 fatty acid content of South African fish oil supplements. | 2011 Nov-Dec | Cardiovasc J Afr | pmid:22159321 |
Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
Kawabata T et al. | Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21420843 |